KEGG   Rattus norvegicus (rat): 64161
Entry
64161             CDS       T01003                                 

Gene name
Pi4ka, Pik4ca
Definition
(RefSeq) phosphatidylinositol 4-kinase alpha
  KO
K00888  phosphatidylinositol 4-kinase A [EC:2.7.1.67]
Organism
rno  Rattus norvegicus (rat)
Pathway
rno00562  Inositol phosphate metabolism
rno01100  Metabolic pathways
rno04070  Phosphatidylinositol signaling system
Module
rno_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:rno00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    64161 (Pi4ka)
 09130 Environmental Information Processing
  09132 Signal transduction
   04070 Phosphatidylinositol signaling system
    64161 (Pi4ka)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    64161 (Pi4ka)
Enzymes [BR:rno01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.67  1-phosphatidylinositol 4-kinase
     64161 (Pi4ka)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Others
   EFR3-PI4KIII alpha complex and associated proteins
    64161 (Pi4ka)
 Endosome - Golgi transport
   Others
    64161 (Pi4ka)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka Ribosomal_L18_c
Other DBs
NCBI-GeneID: 64161
NCBI-ProteinID: NP_071637
RGD: 621213
Ensembl: ENSRNOG00000060045
UniProt: O08662
Position
11q23
AA seq 2041 aa
MCPVDFHGIFQLDERRRDAVIALGIFLIESDLQHKDCIVPYLLRLLRGLPKVYWVEESTA
RKGRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALLQVLHVLLGMCQALEIQEKEY
LCKYAIPCLIGISKSFGRYSNSEESLLSKLFPKVPPHSLRIPEELEGVRRRSFNDFRSIL
PSNLLTVCQEGTLKRKTSSVSSISQVSPERGMPPPSSPGGSAFHYFEASCLPDGTTLEPE
YYFSTISSSFSVSPLFNGITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEA
NPSADLYYTTFSDPVYLTMFKMLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKIL
HDADRIHSEMSPLKLRCQANAACVDLMVWAVKDEQGAENLCIKLSEKLQSKTSSKVIIAH
LPLLICCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGSDIKI
SVTNEHSESTLNVLPGKKNQPSMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSNR
LYISQESDKDAHLIPDHTIRALGHIAVALRDTPKVMEPILQQKFCQPPSPLDVLIIDQLG
CLVITGNQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAANIQ
EEHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRL
PPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPSKEPL
RSVLQYNSAMKNDTVTPAELNELRSTIINLLDPPPEVSALINKLDFAMSTYLLSVYRLEY
MRVLRSTDPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENE
EELERHAQFLLVNFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSL
SADIHKDQPYYDIPDAPYRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQ
EYLNKHQNWVSGLSQHTGLAMATESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMA
SLNLRNRYAGEVHGMIRFSGATGQMSDLNKMMVQDLITALDHSHPQHYTQAMFKLTAMLI
SSKDCDPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKNGVEVPFMREMAGAWHMTVE
QKFGLFSAETKEADPLAASEASQPRPCPPEVTPHYIWIDFLVQRFEIAKYCSSDQVEIFS
SLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYST
AFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTRSNLDIT
VGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQLHKYYMKRRTLLLSLLATEIE
RLITWYNPLSAPELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPAR
FKNTEAIGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGL
SYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQ
LLAHQFIWNMKTNIYLDEEGHQKDPDIGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKI
TNVSAIIKPYPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKA
PYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQAAIFKVGDDCRQDMLA
LQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDFGMYDYFT
RQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFE
SSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLM
LDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDIP
Y
NT seq 6126 nt   +upstreamnt  +downstreamnt
atgtgcccagtagattttcatggaatcttccagctagatgaaagacggagagatgcagtg
attgctctgggcatttttctcattgagtctgatcttcagcacaaagattgtattgttcct
tatcttcttcgacttctcaggggtcttccaaaagtctattgggtagaagaaagcacagct
cggaaaggcagaggtaacctcccggttgcagaaagcttcagcttctgcctggtgaccttg
ctgtctgatgtggcttgcagggacccctcgcttagggatgagattttagaggcacttttg
caggttttacatgtccttctggggatgtgccaggccctggagattcaagagaaagaatac
ctttgcaagtatgcaatcccatgcctgatagggatctcgaaatcttttggacgttacagc
aattcagaagaatctctcctctcaaagctttttcccaaagtccctcctcattccctgaga
atccccgaagagctagaaggtgtccgaaggcgttcctttaatgacttccgctccatcctg
cccagcaacctgctgactgtctgtcaggagggcacactgaagaggaaaaccagcagtgtg
tccagcatctctcaggttagcccagaacgtggcatgccccctcccagctcccctggagga
tctgcttttcactattttgaagcctcttgcctgcctgatggaaccaccttggagcccgaa
tactacttctctaccatcagctccagtttttctgtctctcccctgttcaatggtatcacc
tataaggagttctatattccactggaaatgcttcgagaactcttaaacttggtaaagaag
attgttgaggagcctgttctcaagtccttagatgcagctgtagccagagtgatggaggcc
aatcccagtgctgacctatactacacgaccttcagtgatcccgtctacctgaccatgttc
aagatgcttcgagacactctgtactatatgaaagacttacccacctcctttgtgaaagag
atccatgattttgtgttggagcagttcaacatgagccaaggggaactccaaaagattctc
catgatgcagacaggatccacagtgagatgagcccactcaaactgcgctgccaagcaaat
gctgcctgcgtagacctcatggtgtgggctgtgaaggatgagcagggtgcagaaaacctt
tgcatcaagctgtctgaaaagctgcagtccaagacatccagcaaggtcatcatcgcccat
ttgcccttgctgatctgctgcctacagggtctgggccgcctatgtgaacggttcccggtg
gtggtccactcagtgacaccatctttgagagactttctggtgattccatccccagtgctg
gtgaagctctataagtaccacagtcagtaccacacagttgctggcagtgatataaaaatt
agtgtcaccaatgagcattctgagtcaactctgaatgtcttgcccggcaagaagaaccag
ccatccatgtatgagcagctccgggacatcgccattgacaacatctgcaggtgcctgaag
gccggcctcaccgtggaccctgtgatcgtggaggccttcctggccagcctctccaaccgg
ctctatatctcccaggagagcgataaggatgctcacttgattcctgaccataccattcgt
gccttgggacacattgcagtggctctgagggataccccaaaggtcatggagccaattctg
cagcagaaattttgccagcccccctcacccctcgatgtgctcatcatcgaccagctgggc
tgcctggttatcactggaaatcaatacatttatcaggaagtgtggaatctcttccaacaa
atcagtgtgaaggccagttcagttgtatattcagccaccaaagactacaaagaccatggc
tacaggcactgctccctcgcagtcatcaatgccctggccaacatcgcagccaacattcag
gaggagcaccttgtggatgagctgttgatgaacctgctggaactgtttgtgcagctgggg
ctggaggggaagagagccagtgagagggccagcgagaaggggcccgccctgaaggcttcc
agcagtgcagggaatttgggagtgctcattcctgtaatagccgtgctcacccgacgattg
ccacccatcaaagaagctaaacctaggctacaaaagcttttccgagacttctggctctac
tctgtgctaatgggattcgctgtggaaggctcagggctctggccggaagagtggtatgaa
ggagtctgtgaaatagcaaccaagtcacctctgcttacctttcccagcaaagagcctctt
cgatcagtcctccagtacaactcagccatgaaaaatgatacagtgaccccggctgagctg
aatgagctccgaagtaccatcatcaacttgctagatcctcctcctgaggtgtctgccctc
atcaacaagctggactttgccatgtccacctatctcttgtctgtgtatcggctggaatac
atgagggtgctgcgttctacagatccagatcgcttccaggtaatgttctgctacttcgag
gataaagctattcagaaagacaaatctgggatgatgcagtgtgtcatcgctgttgctgac
aaagtatttgatgccttcctgaacatgatggcagaaaaagccaagaccaaggagaatgaa
gaggagttggagcggcatgcccagtttctgctggtgaacttcaaccacattcacaagagg
atacgcagagtggctgacaagtacctgtctggtctggtggataagtttccacacttgctc
tggagtgggactgtgctgaagaccatgttggacatcctgcagaccctgtcactatcacta
agtgctgatattcacaaggaccaaccttattatgacattcctgacgccccctatcggatc
acggttcctgacacgtatgaagcccgggagagcatcgtgaaagactttgctgcacgctgt
gggatgatcctgcaggaagccatgaagtgggcacccacggtcactaagtcccacctgcag
gaatatctgaacaagcatcagaactgggtgtcaggactgtcccagcacacgggattggcc
atggccactgagagcatccttcactttgccggctacaacaagcagaacacaactcttggg
gtaactcagctcactgagcgcccggcctgtgtgaagaaagactactccaacttcatggca
tccttgaatttgcgcaaccgctatgccggcgaggtgcacgggatgattcggttctcaggt
gccacaggccagatgtccgacctgaacaaaatgatggtccaggatctgattacagctctg
gaccacagtcatcctcagcactatacccaagccatgttcaaattgacggccatgctcatt
agcagcaaagattgtgacccacagctccttcatcatctgtgttggggtcccctccggatg
ttcaacgagcatggcatggagactgcactagcctgctgggagtggctgctggctggcaag
aatggagtggaagtgccgttcatgcgggagatggcaggagcctggcacatgacagtggag
cagaagttcggcctcttctctgcagaaacaaaggaagcagaccccctggcagcgtcagaa
gcaagtcagccacgaccctgtccccctgaagtgacacctcactacatctggattgatttc
ctggtgcagcggtttgagattgccaagtactgtagctctgaccaggtggagatcttctca
agcctgctgcagcgctccatgtccctccacatcggtggagccagggggagcatgaacagg
catgtggcagccattggaccacgtttcaaactgctgaccctggggctgtccctcctacac
gctgatgtggttccaaatgcaaccattcgaaacgtgcttcgagagaagatctactcaaca
gcctttgactatttcagttgtccaccaaagttccctactcaaggagaaaagaggctgcgt
gaagatataagcatcatgattaagttttggactgccatgttctcagataagaagtacctg
actgccagccaactcgttcccccagataaccaggacacccgaagcaacttggatataact
gtgggctctcgacaacaggctacacagggatggatcaacacataccccctctccagtggc
atgtcaactatctccaaaaaatcaggcatgtctaagaaaaccaaccgaggttcccagctg
cacaagtactacatgaagcgtaggacgctgctgctgtcactgttggccactgagatcgag
cgcctcatcacttggtacaacccgctgtcagccccagagctagagctggaccaggcaggt
gagaacagtgttgccaactggaggtccaagtatatcagcctgagtgagaagcagtggaag
gacaacgtgaaccttgcctggaccatctctccatacctcgctgtgcagctgccagccagg
ttcaagaatacagaagccattggaaatgaagtgacccgtctcgttcgcctggacccagga
gctgttagtgatgtccctgaagctatcaagttccttgtcacctggcacaccatcgatgct
gatgctccagagcttagccatgtgttatgctgggcacccacggacccgcccacgggcctc
tcctacttctccagcatgtaccccccacaccctctcactgcacagtatggggtgaaagtc
ctgcggtccttccctccggatgccattctgttctacatcccccagattgtgcaggccctc
agatatgacaagatgggctatgtgcgcgagtacattctctgggctgcagccaaatcccag
cttctggcacaccagtttatttggaatatgaaaactaacatctaccttgatgaagaaggg
caccagaaagaccctgacattggtgaccttctggagcagttagtagaagaaatcacaggg
tctctatcaggcccagccaaagatttctatcaacgggaatttgatttctttaacaagatc
accaacgtgtcagctatcatcaagccctaccctaaaggcgatgaaagaaagaaggcttgt
ctgtcagccctgtctgaagtgaaggtgcagcctggctgctacctgcccagcaaccctgaa
gcaattgtgctagacattgactacaagtcagggacaccaatgcagagtgctgcaaaagcg
ccgtatcttgccaagtttaaggtgaagcgatgcggagtgagtgaacttgaaaaagaaggt
ctgcagtgccgctcagacacagaggatgagtgccgcaggcaagaggctgatggcaagaag
atctgctggcaagcagccatcttcaaagtgggggatgactgccgacaggacatgctagcc
ctgcagatcatcgaccttttcaagaacatcttccagctggttggcctggacctcttcgtt
tttccctatcgggtagtggctactgcccctgggtgtggggtgattgagtgcattccagac
tgtacctcccgagaccagctaggccgccagactgacttcggcatgtatgactactttaca
cgccagtatggggacgagtctaccttggccttccagcaggcacgctacaactttatcaga
agcatggcggcctacagcctcctgctgttcctgctgcagatcaaggacaggcacaacggc
aacatcatgctggacaagaagggacacatcatccacatagactttggcttcatgtttgaa
agctcaccgggtggcaaccttggctgggagccagacatcaagctgacagacgagatggtg
atgattatggggggcaagatggaagccacacccttcaagtggttcatggagatgtgcgtc
cgaggttatctggctgtgcgcccctatatggatgcagtcgtctccctggttacactcatg
ttggacacaggcctgccctgtttccgtggccagacaatcaaacttttgaaacacaggttc
agcccgaacatgacagagcgggaggctgcaaattttatcatgaagatcatccaaaactgt
ttcctcagcaacaggagccggacctacgacatgatccagtactaccagaatgatatcccc
tactga

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