KEGG   Rattus norvegicus (rat): 81504Help
Entry
81504             CDS       T01003                                 

Gene name
Grb2, Ash-psi
Definition
(RefSeq) growth factor receptor bound protein 2
  KO
K04364  growth factor receptor-binding protein 2
Organism
rno  Rattus norvegicus (rat)
Pathway
rno01521  EGFR tyrosine kinase inhibitor resistance
rno01522  Endocrine resistance
rno04010  MAPK signaling pathway
rno04012  ErbB signaling pathway
rno04014  Ras signaling pathway
rno04062  Chemokine signaling pathway
rno04068  FoxO signaling pathway
rno04072  Phospholipase D signaling pathway
rno04150  mTOR signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04380  Osteoclast differentiation
rno04510  Focal adhesion
rno04540  Gap junction
rno04550  Signaling pathways regulating pluripotency of stem cells
rno04630  Jak-STAT signaling pathway
rno04650  Natural killer cell mediated cytotoxicity
rno04660  T cell receptor signaling pathway
rno04662  B cell receptor signaling pathway
rno04664  Fc epsilon RI signaling pathway
rno04714  Thermogenesis
rno04722  Neurotrophin signaling pathway
rno04910  Insulin signaling pathway
rno04912  GnRH signaling pathway
rno04915  Estrogen signaling pathway
rno04917  Prolactin signaling pathway
rno04926  Relaxin signaling pathway
rno04935  Growth hormone synthesis, secretion and action
rno05034  Alcoholism
rno05160  Hepatitis C
rno05161  Hepatitis B
rno05163  Human cytomegalovirus infection
rno05165  Human papillomavirus infection
rno05200  Pathways in cancer
rno05203  Viral carcinogenesis
rno05205  Proteoglycans in cancer
rno05206  MicroRNAs in cancer
rno05210  Colorectal cancer
rno05211  Renal cell carcinoma
rno05213  Endometrial cancer
rno05214  Glioma
rno05215  Prostate cancer
rno05220  Chronic myeloid leukemia
rno05221  Acute myeloid leukemia
rno05223  Non-small cell lung cancer
rno05224  Breast cancer
rno05225  Hepatocellular carcinoma
rno05226  Gastric cancer
rno05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:rno00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    81504 (Grb2)
   04010 MAPK signaling pathway
    81504 (Grb2)
   04012 ErbB signaling pathway
    81504 (Grb2)
   04630 Jak-STAT signaling pathway
    81504 (Grb2)
   04068 FoxO signaling pathway
    81504 (Grb2)
   04072 Phospholipase D signaling pathway
    81504 (Grb2)
   04151 PI3K-Akt signaling pathway
    81504 (Grb2)
   04150 mTOR signaling pathway
    81504 (Grb2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    81504 (Grb2)
   04540 Gap junction
    81504 (Grb2)
   04550 Signaling pathways regulating pluripotency of stem cells
    81504 (Grb2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    81504 (Grb2)
   04660 T cell receptor signaling pathway
    81504 (Grb2)
   04662 B cell receptor signaling pathway
    81504 (Grb2)
   04664 Fc epsilon RI signaling pathway
    81504 (Grb2)
   04062 Chemokine signaling pathway
    81504 (Grb2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    81504 (Grb2)
   04912 GnRH signaling pathway
    81504 (Grb2)
   04915 Estrogen signaling pathway
    81504 (Grb2)
   04917 Prolactin signaling pathway
    81504 (Grb2)
   04926 Relaxin signaling pathway
    81504 (Grb2)
   04935 Growth hormone synthesis, secretion and action
    81504 (Grb2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    81504 (Grb2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    81504 (Grb2)
  09159 Environmental adaptation
   04714 Thermogenesis
    81504 (Grb2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    81504 (Grb2)
   05206 MicroRNAs in cancer
    81504 (Grb2)
   05205 Proteoglycans in cancer
    81504 (Grb2)
   05203 Viral carcinogenesis
    81504 (Grb2)
   05231 Choline metabolism in cancer
    81504 (Grb2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    81504 (Grb2)
   05225 Hepatocellular carcinoma
    81504 (Grb2)
   05226 Gastric cancer
    81504 (Grb2)
   05214 Glioma
    81504 (Grb2)
   05221 Acute myeloid leukemia
    81504 (Grb2)
   05220 Chronic myeloid leukemia
    81504 (Grb2)
   05211 Renal cell carcinoma
    81504 (Grb2)
   05215 Prostate cancer
    81504 (Grb2)
   05213 Endometrial cancer
    81504 (Grb2)
   05224 Breast cancer
    81504 (Grb2)
   05223 Non-small cell lung cancer
    81504 (Grb2)
  09165 Substance dependence
   05034 Alcoholism
    81504 (Grb2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    81504 (Grb2)
   05160 Hepatitis C
    81504 (Grb2)
   05163 Human cytomegalovirus infection
    81504 (Grb2)
   05165 Human papillomavirus infection
    81504 (Grb2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    81504 (Grb2)
   01522 Endocrine resistance
    81504 (Grb2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:rno04131]
    81504 (Grb2)
Membrane trafficking [BR:rno04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    81504 (Grb2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 hSH3 DUF5093 SH3_3 SH3_4
Motif
Other DBs
NCBI-GeneID: 81504
NCBI-ProteinID: NP_110473
RGD: 619758
Ensembl: ENSRNOG00000003990
UniProt: P62994
Position
10q32.1
AA seq 217 aa AA seqDB search
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt NT seq  +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgctgacgatgagctgagcttcaag
aggggggacatccttaaggttttgaatgaagagtgtgatcagaactggtataaggcagaa
ctcaatgggaaagatggcttcatccccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagcaaaggcagaagaaatgcttagcaaacagcggcatgac
ggggccttcctgatccgagagagcgagagcgctcctggggatttctccctgtcagtcaag
tttggaaatgatgtacagcacttcaaggtgcttcgtgacggagccgggaagtacttcctg
tgggtggtgaagtttaattctttgaatgagctggtagattaccacagatcaacatccgtg
tccaggaaccagcagatattcctccgggacatagaacaggtgccacagcagccaacgtac
gtccaggcactctttgactttgacccccaggaggatggtgagctgggctttcgccgagga
gacttcattcatgtcatggataactcagatcccaattggtggaaaggggcctgccatggg
cagaccggcatgtttccccgcaattatgtcaccccagtgaaccggaacgtctaa

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