KEGG   Rhinopithecus roxellana (golden snub-nosed monkey): 104662674
Entry
104662674         CDS       T03989                                 

Gene name
ADCY4
Definition
(RefSeq) adenylate cyclase type 4 isoform X1
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
rro  Rhinopithecus roxellana (golden snub-nosed monkey)
Pathway
rro00230  Purine metabolism
rro01100  Metabolic pathways
rro01522  Endocrine resistance
rro04015  Rap1 signaling pathway
rro04020  Calcium signaling pathway
rro04022  cGMP-PKG signaling pathway
rro04024  cAMP signaling pathway
rro04062  Chemokine signaling pathway
rro04072  Phospholipase D signaling pathway
rro04114  Oocyte meiosis
rro04211  Longevity regulating pathway
rro04213  Longevity regulating pathway - multiple species
rro04261  Adrenergic signaling in cardiomyocytes
rro04270  Vascular smooth muscle contraction
rro04371  Apelin signaling pathway
rro04540  Gap junction
rro04611  Platelet activation
rro04713  Circadian entrainment
rro04714  Thermogenesis
rro04723  Retrograde endocannabinoid signaling
rro04724  Glutamatergic synapse
rro04725  Cholinergic synapse
rro04727  GABAergic synapse
rro04742  Taste transduction
rro04750  Inflammatory mediator regulation of TRP channels
rro04911  Insulin secretion
rro04912  GnRH signaling pathway
rro04913  Ovarian steroidogenesis
rro04914  Progesterone-mediated oocyte maturation
rro04915  Estrogen signaling pathway
rro04916  Melanogenesis
rro04918  Thyroid hormone synthesis
rro04921  Oxytocin signaling pathway
rro04923  Regulation of lipolysis in adipocytes
rro04925  Aldosterone synthesis and secretion
rro04926  Relaxin signaling pathway
rro04927  Cortisol synthesis and secretion
rro04928  Parathyroid hormone synthesis, secretion and action
rro04934  Cushing syndrome
rro04935  Growth hormone synthesis, secretion and action
rro04970  Salivary secretion
rro04971  Gastric acid secretion
rro04972  Pancreatic secretion
rro04976  Bile secretion
rro05032  Morphine addiction
rro05163  Human cytomegalovirus infection
rro05166  Human T-cell leukemia virus 1 infection
rro05200  Pathways in cancer
rro05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:rro00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    104662674 (ADCY4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    104662674 (ADCY4)
   04371 Apelin signaling pathway
    104662674 (ADCY4)
   04020 Calcium signaling pathway
    104662674 (ADCY4)
   04072 Phospholipase D signaling pathway
    104662674 (ADCY4)
   04024 cAMP signaling pathway
    104662674 (ADCY4)
   04022 cGMP-PKG signaling pathway
    104662674 (ADCY4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    104662674 (ADCY4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    104662674 (ADCY4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    104662674 (ADCY4)
   04062 Chemokine signaling pathway
    104662674 (ADCY4)
  09152 Endocrine system
   04911 Insulin secretion
    104662674 (ADCY4)
   04923 Regulation of lipolysis in adipocytes
    104662674 (ADCY4)
   04912 GnRH signaling pathway
    104662674 (ADCY4)
   04913 Ovarian steroidogenesis
    104662674 (ADCY4)
   04915 Estrogen signaling pathway
    104662674 (ADCY4)
   04914 Progesterone-mediated oocyte maturation
    104662674 (ADCY4)
   04921 Oxytocin signaling pathway
    104662674 (ADCY4)
   04926 Relaxin signaling pathway
    104662674 (ADCY4)
   04935 Growth hormone synthesis, secretion and action
    104662674 (ADCY4)
   04918 Thyroid hormone synthesis
    104662674 (ADCY4)
   04928 Parathyroid hormone synthesis, secretion and action
    104662674 (ADCY4)
   04916 Melanogenesis
    104662674 (ADCY4)
   04925 Aldosterone synthesis and secretion
    104662674 (ADCY4)
   04927 Cortisol synthesis and secretion
    104662674 (ADCY4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    104662674 (ADCY4)
   04270 Vascular smooth muscle contraction
    104662674 (ADCY4)
  09154 Digestive system
   04970 Salivary secretion
    104662674 (ADCY4)
   04971 Gastric acid secretion
    104662674 (ADCY4)
   04972 Pancreatic secretion
    104662674 (ADCY4)
   04976 Bile secretion
    104662674 (ADCY4)
  09156 Nervous system
   04724 Glutamatergic synapse
    104662674 (ADCY4)
   04727 GABAergic synapse
    104662674 (ADCY4)
   04725 Cholinergic synapse
    104662674 (ADCY4)
   04723 Retrograde endocannabinoid signaling
    104662674 (ADCY4)
  09157 Sensory system
   04742 Taste transduction
    104662674 (ADCY4)
   04750 Inflammatory mediator regulation of TRP channels
    104662674 (ADCY4)
  09149 Aging
   04211 Longevity regulating pathway
    104662674 (ADCY4)
   04213 Longevity regulating pathway - multiple species
    104662674 (ADCY4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    104662674 (ADCY4)
   04714 Thermogenesis
    104662674 (ADCY4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    104662674 (ADCY4)
  09165 Substance dependence
   05032 Morphine addiction
    104662674 (ADCY4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    104662674 (ADCY4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    104662674 (ADCY4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    104662674 (ADCY4)
   05163 Human cytomegalovirus infection
    104662674 (ADCY4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    104662674 (ADCY4)
Enzymes [BR:rro01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     104662674 (ADCY4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N DUF3180 CD52
Other DBs
NCBI-GeneID: 104662674
NCBI-ProteinID: XP_010362015
Position
5
AA seq 1190 aa
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPS
FLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQV
SYFLFVIFTVYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVL
FLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMK
AEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE
LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATG
VDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAG
AYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSLLMTR
YLESWGAAKPFAHLSHVDSPVSTSTPLQEKTLASFSPQWSLDRSRNPRGLDDELDTGDAK
FFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFI
IQMLVTNRPPALAITYSITFLLFLLLLFVCFSEDLMRCALKGPKMLHWLPALSGLVATRP
GLRIALSTATILLVFALATTSLDLDSFLEFYSWRAPGNHPSAKLQKRKLRPREAKWLARA
HTVAQSQRSTLDAPHITPPPVRTPVLRFPSLPEIAESTPLDESGPDSSLGQLKPSTSHHC
AQETTCLFSSSSPLQFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTL
GFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSDCLIVRLYLGPLDSRPGVLKE
PKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLP
AHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIA
DFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALG
SKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQ
VTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRSGPPSVTLG
NT seq 3573 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagcccccggccaccccccagcgaagacctcttctacgagacctac
tacagcctgagccagcagtacccgctgctgctgctgctgctggggatcgtgctctgtgcg
ctcgcggcgctgctcgcggttgcctgggccagcggcagggagctgacttcagacccgagc
ttcctgaccactgtgctgtgcgcgctgggcggcttctcgctgctgctgggcctcgcttcc
cgcgagcagcgactgcagcgctggacgcgtcctctgtccggcttggtgtgggtcgcgctg
ctagcgctaggccacgccttcctgttcaccgggggcgtggtgagcgcctgggaccaggtg
tcctattttctcttcgtcatcttcacggtgtatgccatgctgcccttgggcatgcgggac
gccgccgtcgcgggcctcgcctcctcactctcgcatctactggtcctggggctgtatctt
gggccacagccggactcacggcctgcactgctgccgcagttggcagcaaatgcagtgctg
ttcctgtgcgggaacgtggcaggagtgtaccacaaggcgctgatggagcgcgccctgcgg
gccacgttccgggaggcactcagctccttgcactcgcgccggcggctggacaccgaaaag
aagcaccaggaacaccttctcttgtccatccttcctgcctacctggcccgagagatgaaa
gcagagatcatggcacggctgcaggcaggacaggggtcacggccagaaagcaccaacaat
ttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtatgctgacattgtg
ggcttcacgcggctggccagcgagtgttcccctaaggagctggtgctcatgctcaatgag
ctctttggcaagtttgaccagatcgccaaggagcatgaatgcatgcggatcaagatcctg
ggggactgttactactgtgtctccggactgccactctcactgccagaccatgccatcaac
tgtgtgcgcatggggctggacatgtgccgggccatcaggaaactgcgggcagccactggc
gtggacatcaacatgcgtgtgggcgtgcactcaggcagtgtactctgtggagtcatcggg
ctgcagaagtggcagtatgacgtttggtcccatgatgttacactggctaaccacatggag
gcaggcggtgtaccagggcgagtgcacatcacaggggctaccctggccctgctggcaggg
gcttatgctgtggaggacgcaggcatggagcatcgggatccctaccttcgggagctaggg
gagcccacttatctggtcattgatccacgggcagaggaggaggatgagaagggcactgca
ggaggcttgctctcctcgcttgagggccccaagatgcgtccatcactgctgatgacccgt
tacctggagtcctggggtgcagccaagccttttgcccacctgagccacgtagacagccct
gtgtccacctccacccctctccaggagaagaccctggcttccttcagcccccagtggagc
ctagatcgaagccgtaacccccgtggactagatgatgaactggacaccggggatgccaag
ttcttccaggtcattgagcagctcaactcacagaaacagtggaagcagtcgaaggacttc
aacccactgacactgtacttcagagagaaggagatggagaaagagtaccgactctctgca
atccccgccttcaaatactatgaagcctgcaccttcctggtttttctctccaacttcatc
atccagatgctagtgacaaacaggcccccagctctggccatcacgtatagcatcaccttc
ctcctcttcctcctcctcctttttgtctgcttctcagaggacctgatgaggtgtgccctg
aaaggccccaagatgctgcattggctgcctgcactgtctggcttggtggccacacgacca
ggactgagaatagccttgagcaccgccaccatcctccttgtctttgccctggccactacc
agcctggatttagactcattcctagaattctattcctggagggcacctgggaatcaccca
tcagccaagttacagaagaggaagctaaggcccagagaggctaagtggctggcaagagct
cacacagtggctcagagtcagagaagtactcttgatgcccctcacataactcctccccca
gtgaggaccccagtgctgaggttcccttccctaccagaaatagcagaatccacccctttg
gacgagtctggccctgactcatctctgggtcagctgaaacccagcacaagccaccattgt
gcccaagaaactacctgcctcttcagctcctcatctcctctgcagttcttcttcccaaca
tcatcagactgccctttccaagctcccaatgtgtcctccatgatttccaacctctcctgg
gagctccctgggtctctgcctctcatcagtgtcccatactccatgcactgctgcacgctg
ggcttcctctcctgctccctctttctgcacatgagcttcgagctgaagctgctgctgctc
ctgctgtggctggcggcatcctgctccctcttcctacactcccacgcctggctgtccgac
tgcctcatcgtccgcctctatctgggccccttggactccaggcccggagtgctgaaggag
cccaaactcatgggtgctatctccttcttcatcttcttcttcaccctccttgtcctggct
cgccagaatgagtactactgccgcctggacttcctgtggaagaagaagctgaggcaggag
cgggaggagacagagacgatggagaacctgactcggctgctcttggagaatgtgctccct
gcacacgtggccccccagttcattggccagaaccggcgcaacgaggatctctaccaccag
tcctacgaatgcgtttgtgtcctcttcgcttcagtcccagacttcaaggagttctactct
gaatccaacatcaatcatgagggcctagagtgtctgaggctgctcaatgaaataattgct
gattttgatgagctgctctccaagcccaagttcagtggggtggagaagatcaagaccatt
ggcagcacctacatggcagccacaggattaaatgccacctctggacaggatgcacaacag
gatgctgaacggagctgcagccaccttggcactatggtggaatttgccgttgccctgggg
tctaagctggacgtcatcaacaagcattcattcaacaacttccgcctgcgtgtggggttg
aaccatggaccagtagtagctggagttattggggcccagaagccacaatatgacatttgg
ggcaacacagtgaacgtggccagccgcatggagagtacaggagtccttggcaaaatccaa
gtgactgaggagacagcctgggccctacagtccctgggctacacctgctacagccggggg
gtcatcaaggtgaaaggcaaagggcagctctgcacctacttcctgaacacagacttgaca
cgaagtggacctccttcagttaccctaggctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (49)   
   KEGG PATHWAY (49)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (8)   
   RefSeq(nuc) (8)   
Protein domain (5)   
   Pfam (5)   
All databases (84)   

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