LOCUS NC_024443 3368 bp DNA circular VRL 13-AUG-2018
DEFINITION Roundleaf bat hepatitis B virus isolate
RBHBV/GB09-256/Hip_rub/GAB/2009, complete genome.
ACCESSION NC_024443
VERSION NC_024443.1
DBLINK BioProject: PRJNA485481
KEYWORDS RefSeq.
SOURCE Roundleaf bat hepatitis B virus (RBHBV)
ORGANISM Roundleaf bat hepatitis B virus
Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
Blubervirales; Hepadnaviridae; Orthohepadnavirus.
REFERENCE 1 (bases 1 to 3368)
AUTHORS Drexler,J.F., Geipel,A., Konig,A., Corman,V.M., van Riel,D.,
Leijten,L.M., Bremer,C.M., Rasche,A., Cottontail,V.M.,
Maganga,G.D., Schlegel,M., Muller,M.A., Adam,A., Klose,S.M., Borges
Carneiro,A.J., Stocker,A., Franke,C.R., Gloza-Rausch,F., Geyer,J.,
Annan,A., Adu-Sarkodie,Y., Oppong,S., Binger,T., Vallo,P.,
Tschapka,M., Ulrich,R.G., Gerlich,W.H., Leroy,E., Kuiken,T.,
Glebe,D. and Drosten,C.
TITLE Bats carry pathogenic hepadnaviruses antigenically related to
hepatitis B virus and capable of infecting human hepatocytes
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 110 (40), 16151-16156 (2013)
PUBMED 24043818
REFERENCE 2 (bases 1 to 3368)
CONSRTM NCBI Genome Project
TITLE Direct Submission
JOURNAL Submitted (24-JUN-2014) National Center for Biotechnology
Information, NIH, Bethesda, MD 20894, USA
REFERENCE 3 (bases 1 to 3368)
AUTHORS Corman,V.M., Drexler,J.F., Glebe,D. and Drosten,C.
TITLE Direct Submission
JOURNAL Submitted (15-MAR-2013) Institute of Virology, University of Bonn
Medical Centre, Sigmund Freud-Str. 25, Bonn 53127, Germany
COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final
NCBI review. The reference sequence is identical to KC790373.
##Assembly-Data-START##
Sequencing Technology :: Sanger dideoxy sequencing
##Assembly-Data-END##
COMPLETENESS: full length.
FEATURES Location/Qualifiers
source 1..3368
/organism="Roundleaf bat hepatitis B virus"
/mol_type="genomic DNA"
/isolate="RBHBV/GB09-256/Hip_rub/GAB/2009"
/host="Hipposideros cf. ruber"
/db_xref="taxon:1508710"
/country="Gabon"
/collection_date="2009"
gene join(2147..3368,1..1478)
/locus_tag="HM84_gp1"
/db_xref="GeneID:19737426"
CDS join(2147..3368,1..1478)
/locus_tag="HM84_gp1"
/codon_start=1
/product="polymerase"
/protein_id="YP_009045991.1"
/db_xref="GeneID:19737426"
/translation="MHPFSRLFRSIQSLGEEEVHALLGPPEGALPLLADADLNRRVAA
DLSLQLPPTASIWVHKAGGLTGLYSDKPKSFNPHWKTPEFPQLHLRPDLIEYLTHRLG
PLTSAEKRRFRLCIPARFFPNKTKYFPLYKGIKPYYPDNLLTHFFLTSHYLRTLWEAG
VTYLRETQSSASFNGSPYPWEQKQHNHGTERINSKPSRVLPGTRSTTRLRKAGNGPCT
RPLHLLGQSPLQRSRQREASSLGKGRSSPRLGSRTHTSSRRPFGVNRDLPGGTNHFPP
RWLDHKNSDRKTSHHHTTSTYQTKQAKGGAKGRILPNSYTTATSSRTYQSEAFSDTSH
NTTQSEQGEDTHSPYSSGAGHSSSPEHDQPDVEGAIRPSPLCAWSYLRSHPACGPHCL
KQCTLLLDDWGPCSRHGEHLIRTPRTPRRISGGVFLVDKNPNNSAESRLVVDFSQFSR
GDSRVLWPKFAVPNLQALTNLLSTNLCWLSLDVSAAFYHIPLSPAAMPHLLVGSPGLE
GLAASVSPQPKQPDNHEMHILHNLCGRANLLSLLLLFKTFGRELHLLAHSFIMGFRKI
PMGVGLSPFLLAQFTSALASVVRRTFAHCVAFSYMDDVVLGARTPQHLESVYASVCSL
FSSLGIHLNPSKTKWWGKHLHFMGLVLSPAGALPQTKHQSRALSCLKRLPTYVVLDWK
LLQRLTGLLGFLAPFTACGYPALMPLYAAVQARRGFEFSPAYKGFLLQLYSHLLPVAR
QRRAVCQVFADATPTGWGLVNHQLAAYKAGRFPRPLPIHCAELIAACLARRWSGARVL
GVDNTIVCSGKFTHFPWLLGCTANWMLRGTSFCYVPSELNPADAPSRGLLGILLAPPP
LLFRPSTGRTSLFAVSPPAPFHRPDRVSFASPVRTFKDTWRPP"
misc_feature 2186..3361
/locus_tag="HM84_gp1"
/note="DNA polymerase (viral) N-terminal domain; Region:
DNA_pol_viral_N; pfam00242"
/db_xref="CDD:365972"
misc_feature <465..731
/locus_tag="HM84_gp1"
/note="Reverse transcriptase (RT, RNA-dependent DNA
polymerase)_like family. An RT gene is usually indicative
of a mobile element such as a retrotransposon or
retrovirus. RTs occur in a variety of mobile elements,
including retrotransposons, retroviruses, group...;
Region: RT_like; cl02808"
/db_xref="CDD:445932"
misc_feature 483..485
/locus_tag="HM84_gp1"
/note="nucleic acid binding site [nucleotide binding];
other site"
/db_xref="CDD:238185"
misc_feature 741..1436
/locus_tag="HM84_gp1"
/note="DNA polymerase (viral) C-terminal domain; Region:
DNA_pol_viral_C; pfam00336"
/db_xref="CDD:366036"
gene 1..675
/locus_tag="HM84_gp2"
/db_xref="GeneID:19737423"
CDS 1..675
/locus_tag="HM84_gp2"
/codon_start=1
/product="surface protein"
/protein_id="YP_009045992.1"
/db_xref="GeneID:19737423"
/translation="MGNISSELLGPLVGFQVVFFLWTKILTIAQSLDSWWTSLSFPGG
IPECFGLNLQSQTCKHSPTSCPPTCAGFRWMCLRRFIIYLLVLLLCLIFLLVLLDWRG
LLPVCPLNPNNQTTMRCTSCTISADALTSFPYCCCSKPSGGNCTCWPIPSSWAFAKFL
WELASLRFSWLNSLVPWLQWFAGLSPTAWLLAIWMMWYWGPGLLNTLSPFMPLFVLFF
LLWGYI"
misc_feature <1..672
/locus_tag="HM84_gp2"
/note="Major surface antigen from hepadnavirus; Region:
vMSA; pfam00695"
/db_xref="CDD:366252"
gene 1220..1645
/locus_tag="HM84_gp3"
/db_xref="GeneID:19737424"
CDS 1220..1645
/locus_tag="HM84_gp3"
/codon_start=1
/product="X protein"
/protein_id="YP_009045993.1"
/db_xref="GeneID:19737424"
/translation="MAARLHCELDAARDVVLLRPLGVEPRGRPFPRPPRDPPRAAAAA
VPPFHRSDLPVRRLPACAFSSAGPCVLRFTCADLQRHMETPLNFVTWQGARQRGHFLR
TLDYWDWYIKQSLMNQWEELGLGERLNTYVLGGCRHKLK"
misc_feature 1220..1639
/locus_tag="HM84_gp3"
/note="Trans-activation protein X; Region: X; pfam00739"
/db_xref="CDD:109783"
gene 1657..2310
/locus_tag="HM84_gp4"
/db_xref="GeneID:19737425"
CDS 1657..2310
/locus_tag="HM84_gp4"
/codon_start=1
/product="core protein"
/protein_id="YP_009045994.1"
/db_xref="GeneID:19737425"
/translation="MYLFHLCLIFCSYPTVQASKLCLGWLWDMDIDPYKEFGASSQLI
SFLPEDFFPNLAELVETTTALYEEELVGKEHCSPHHTALRSLLNCWGETVRLITWVRN
SVEGPLIQDAIVQQVQASVGLRMRQLMWFHLSCLTFGQPTVIEFLVSFGTWIRTPQAY
RPPNAPILSTLPEHTIVRRRGGSRATRSPRRRTPSPRRRRSQSPRRRRSQSPASSNC"
misc_feature 1657..1734
/locus_tag="HM84_gp4"
/note="Hepatitis core protein, putative zinc finger;
Region: Hep_core_N; pfam08290"
/db_xref="CDD:429902"
misc_feature 1744..>2205
/locus_tag="HM84_gp4"
/note="Hepatitis core antigen; Region: Hepatitis_core;
pfam00906"
/db_xref="CDD:279277"
ORIGIN
1 atggggaaca tctcatcaga actcctcgga cccctcgtag gatttcaggt ggtgtttttc
61 ttgtggacaa aaatcctaac aatagcgcag agtctagact cgtggtggac ttctctcagt
121 tttcccgggg ggattccaga gtgctttggc ctaaatttgc agtcccaaac ctgcaagcac
181 tcaccaacct cctgtccacc aacctgtgct ggctttcgct ggatgtgtct gcggcgtttt
241 atcatatacc tcttagtcct gctgctatgc ctcatcttct tgttggttct cctggactgg
301 aggggcttgc tgccagtgtg tcccctcaac ccaaacaacc agacaaccat gagatgcaca
361 tcctgcacaa tctctgcgga cgcgctaacc tcctttccct actgctgttg ttcaaaacct
421 tcgggaggga attgcacctg ctggcccatt ccttcatcat gggctttcgc aaaattccta
481 tgggagttgg cctctctccg tttctcctgg ctcaattcac tagtgccctg gcttcagtgg
541 ttcgcaggac tttcgcccac tgcgtggctt ttagctatat ggatgatgtg gtattggggg
601 ccaggactcc tcaacacctt gagtccgttt atgcctctgt ttgttctctt ttttcttctc
661 tggggataca tttaaatccc tccaagacta aatggtgggg caaacatctg catttcatgg
721 gactcgtcct gtcccccgct ggggccctgc cacaaaccaa acatcagtcc cgtgctctct
781 cttgtctcaa acgtctcccc acttatgtgg tcctggactg gaaacttctg caacgcctaa
841 cgggcctttt ggggtttcta gcccccttca cggcctgcgg ctacccggcc ctcatgccgc
901 tttacgcggc cgttcaggcc aggcgcggtt ttgaattttc cccggcatac aaagggtttc
961 ttttgcagct ctacagtcac ctcctccccg ttgctaggca acggcgggcg gtttgccagg
1021 tgtttgctga cgcaaccccc actggctggg gcctggttaa tcatcagctc gctgcttata
1081 aggcgggtcg ctttccgcga cctttgccca tccactgcgc ggagctgatc gccgcctgtc
1141 tcgctcgccg ctggtcgggg gctcgagtgt tgggggtcga caataccatc gtgtgctccg
1201 ggaagttcac gcacttccca tggctgctcg gctgcactgc gaactggatg ctgcgcggga
1261 cgtcgttctg ctacgtcccc tcggagttga accccgcgga cgccccttcc cgcggcctcc
1321 tcgggatcct cctcgcgccg ccgccgctgc tgttccgccc ttccaccggt cggacctccc
1381 tgttcgccgt ctccccgcct gcgccttttc atcggccgga ccgtgtgtcc ttcgcttcac
1441 ctgtgcggac cttcaaagac acatggagac ccccctgaac tttgtcactt ggcagggggc
1501 ccgtcaacgt ggacactttc taagaacttt ggactactgg gactggtaca ttaaacaatc
1561 attaatgaat caatgggagg agctgggctt aggtgaaagg ttaaatacat atgtattagg
1621 aggctgtagg cataaattga agtgatccac ttcatcatgt atctttttca cctgtgcctg
1681 atcttttgtt catatcccac tgttcaagcc tccaagctgt gccttggctg gctttgggat
1741 atggacattg atccttataa agaatttgga gcttcatctc aactgatctc tttcttgcct
1801 gaggactttt tcccaaatct tgcagaattg gtcgagacca ccacagctct ctatgaagaa
1861 gaattagtag gtaaggagca ttgctcccct caccatactg ctttacgatc cttgctaaat
1921 tgctggggag agactgttag attaataact tgggtcagga attctgtgga gggaccactc
1981 atacaagatg ccattgtcca gcaagttcag gcctcggtgg gcctgcgcat gagacagtta
2041 atgtggttcc atctctcatg cctaacattt ggacagccca ctgtcataga atttctggtc
2101 tcttttggaa catggatcag aaccccgcaa gcttacagac cccctaatgc acccattctc
2161 tcgactcttc cggagcatac aatcgttagg agaagaggag gttcacgcgc tactaggtcc
2221 ccccgaaggc gcactccctc tcctcgccga cgcagatctc aatcgccgcg tcgccgcaga
2281 tctcagtctc cagcttcctc caactgctag tatctgggtg cacaaggcag gggggcttac
2341 gggactctat tctgacaaac ccaaatcatt caatccacat tggaaaactc ctgaatttcc
2401 acaattacat ctgagacctg accttatcga atatttgacc catagacttg ggccactcac
2461 atcagctgaa aaaaggagat tcaggctgtg cattccagcc agattttttc caaacaaaac
2521 taaatacttt cctctttaca agggaatcaa gccctattat ccagataacc tgctcaccca
2581 cttctttctg acatctcact atctcagaac tttgtgggaa gcaggagtca catatttgag
2641 agaaactcaa tcctcagcat cctttaacgg atcaccttat ccctgggaac aaaaacagca
2701 taaccatggg acagaacgga tcaattccaa acccagtagg gttcttcccg ggacacgaag
2761 tactaccaga cttagaaaag ctgggaacgg accctgcact cggcccttac acctattggg
2821 acagagtccc cttcaaagat ccagacagag agaagcttcg agcctgggca aggggagatc
2881 ctcccccaga ttgggctccc gcactcacac ctcctcgcgg aggccttttg gggtcaacag
2941 agatctccca gggggtacta accactttcc acccagatgg ctcgatcaca aaaacagtga
3001 caggaaaacc tcccatcatc ataccacctc cacctaccaa accaaacaag caaaaggggg
3061 ggcaaaagga cggatcctcc ctaattctta cacaaccgcc acctcctctc gaacctacca
3121 atcagaagcc tttagcgaca cctcccacaa caccacccaa tcggagcagg gggaggatac
3181 ccactccccc tactcctccg gtgcgggtca ctcatcctca cctgaacatg accaaccaga
3241 cgtggaggga gcgatacggc catctcctct ctgcgcctgg tcctacctcc gctcccatcc
3301 agcctgcgga ccccactgtc tcaagcagtg cacccttctc ctggacgact ggggaccttg
3361 ctctcgac
//
