KEGG   Staphylococcus aureus subsp. aureus MRSA252 (MRSA): SAR2144
Entry
SAR2144           CDS       T00182                                 
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
sar  Staphylococcus aureus subsp. aureus MRSA252 (MRSA)
Pathway
sar00290  Valine, leucine and isoleucine biosynthesis
sar00620  Pyruvate metabolism
sar01100  Metabolic pathways
sar01110  Biosynthesis of secondary metabolites
sar01210  2-Oxocarboxylic acid metabolism
sar01230  Biosynthesis of amino acids
Module
sar_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:sar00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    SAR2144 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    SAR2144 (leuA)
Enzymes [BR:sar01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     SAR2144 (leuA)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer
Other DBs
NCBI-ProteinID: CAG41125
UniProt: Q6GF16
Position
2207139..2208668
AA seq 509 aa
MSSHIQIFDTTLRDGEQTPGVNFTFDERLRIALQLEKWGVDVIEAGFPASSTGSFKSVQA
IAQTLTTTAVCGLARCKKSDIDAVYEATKDAAKPVVHVFIATSPIHLEHKLKMSQEDVLA
SIKEHVTYAKQLFDVVQFSPEDATRTELPFLVKCVQTAVDAGATVINIPDTVGYSYHDEY
AHIFKTLTESVTSSNEIIYSAHCHDDLGMAVSNSLAAIEGGARRIEGTVNGIGERAGNAA
LEEVALALYIRNDHYGAQTALNLEETKKTSDLISRYAGIRVPRNKAIVGQNAFSHESGIH
QDGVLKHRETYEIMTPQLVGVSTTELPLGKLSGKHAFSKKLKALGYDIDKEAQIDLFKQF
KAIADKKKSVSDRDIHAIIQGSEHEHQALYKLETLQLQYVSSGLQSAVVVIKDKEGHIYQ
DSSIGTGSIVAIYNAVDRIFQKETELIDYRINSVTEGTDAQAEVHVNLLIEGKTVNGFGI
DHDILQASCKAYVEAHAKFAAENVEKVGN
NT seq 1530 nt   +upstreamnt  +downstreamnt
atgagtagtcatattcaaatttttgatacgacactaagagacggtgaacaaacaccagga
gtgaattttacttttgatgaacgcttgcgtattgcattgcaattagaaaaatggggtgta
gatgttattgaagctggatttcctgcttcaagtacaggtagctttaaatctgttcaagca
attgcacaaacattaacaacaacggctgtatgtggtttagctagatgtaaaaaatctgac
atcgatgctgtatatgaagcaacaaaagatgcagcgaagccggtcgtgcatgtttttata
gcaacatcacctattcatcttgaacataaacttaaaatgtctcaagaagacgttttagca
tctattaaagaacatgtcacatacgcgaaacaattatttgatgttgttcaattttcacct
gaagatgcaacgcgtactgaattaccattcttagtgaaatgtgtacaaactgcagttgac
gctggagctacagttattaatattcctgatacagtcggctacagttaccatgatgaatat
gcacatattttcaaaaccttaacagaatctgtaacatcttcaaatgaaattatttatagt
gctcattgccatgacgatttaggaatggctgtttcaaatagtttagctgcgattgaaggc
ggtgcgagacgaattgaaggcactgtaaatggtattggtgaacgagcaggtaatgcagca
cttgaagaagtcgcgcttgcactatacattcgaaatgatcattatggtgctcaaactgcc
cttaatctcgaagaaactaaaaaaacatcggatttaatttcaagatatgcaggtattcga
gtgcctagaaataaagcaattgttggccaaaatgcatttagtcatgaatcaggtattcac
caagatggcgtattaaaacatcgtgaaacatatgaaattatgacacctcaacttgttggt
gtaagcacgactgaacttccattaggaaaattatctggtaaacacgccttctcaaagaag
ttaaaagcattaggttatgacattgataaagaagcgcaaatagatttatttaaacaattc
aaggccattgcggacaaaaagaaatctgtttcagatagagatattcatgcgattattcaa
ggttctgagcatgagcatcaagcactttataaattggaaacactgcaactacaatatgtc
tctagcggccttcaaagtgctgttgttgttattaaagataaagagggtcatatttaccag
gattcaagtattggtactggttcaatcgtagcaatttacaatgcagttgatcgtattttc
caaaaagaaacagaattaattgattatcgtattaattctgtcactgaaggtactgatgcc
caagcagaagtacatgtaaatttattgattgaaggtaagactgtcaatggctttggtatt
gatcatgatattttacaagcctcatgtaaggcatacgtagaagcacatgctaaatttgca
gctgaaaatgttgaaaaggtaggtaattaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   Pfam (2)   
All databases (24)   

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