KEGG   Saccharopolyspora erythraea: SACE_6144
Entry
SACE_6144         CDS       T00492                                 

Gene name
leuC
Definition
(GenBank) 3-isopropylmalate dehydratase large subunit
  KO
K01703  3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
Organism
sen  Saccharopolyspora erythraea
Pathway
sen00290  Valine, leucine and isoleucine biosynthesis
sen00660  C5-Branched dibasic acid metabolism
sen01100  Metabolic pathways
sen01110  Biosynthesis of secondary metabolites
sen01210  2-Oxocarboxylic acid metabolism
sen01230  Biosynthesis of amino acids
Module
sen_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:sen00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00660 C5-Branched dibasic acid metabolism
    SACE_6144 (leuC)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    SACE_6144 (leuC)
Enzymes [BR:sen01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.33  3-isopropylmalate dehydratase
     SACE_6144 (leuC)
    4.2.1.35  (R)-2-methylmalate dehydratase
     SACE_6144 (leuC)
SSDB
Motif
Pfam: Aconitase AcnX
Other DBs
NCBI-ProteinID: CAM05317
Cambridge: SACE_6144
Kitasato: SACE_6144
UniProt: A4FMP2
Position
complement(6889069..6890472)
AA seq 467 aa
MGKTLAEKVWEAHIVRRGEGYEPDLLYIDLHLVHEVTSPQAFEGLRLAGRQVRRPDLTLA
TEDHNVPTTGIDLPIADPVSRTQVDTLRRNCEEFGIRLHPMGDAEQGIVHVVGPQLGLTQ
PGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQTLPLRPFKTMAINIEGTLRPGVT
SKDVILAVIAKIGTGGGQGYVLEYRGSAVEKMSMEARMTMCNMSIEAGARAGMIAPDETT
FAYLQGRPHAPEGTEWDAAVEYWKTLRTDEDAEFDAEVTLDADELTPFVTWGTNPGQGLP
LGARIPDPAAIADESERFATEKALDYMGLEAGTPLREVAVDTVFLGSCTNGRIEDLRAAA
DVLKGRKVASEVRMLVVPGSMRVRKQAEAEGLNEVFTAAGAEWRSAGCSMCLGMNPDQLT
PGERSASTSNRNFEGRQGKGGRTHLVSPLVAAATAVRGTLSSPEDLD
NT seq 1404 nt   +upstreamnt  +downstreamnt
atgggcaagacgctcgcggagaaggtctgggaagcgcacatcgtgcgccgcggcgagggc
tacgagcccgacctgctctacatcgacctccacctcgttcacgaggtcaccagcccgcag
gccttcgaggggctgcgcctggcggggcggcaggtgcgccgtcccgacctgacgctggcc
accgaggaccacaacgtgcccaccacgggcatcgacctgccgatcgcggacccggtttcg
cggacccaggtcgacaccctgcggcgcaactgcgaggagttcggcatccgcctgcacccg
atgggcgacgccgagcagggcatcgtgcacgtggtggggccccagctcggcctcacccag
cccggcacgaccgtcgtctgcggcgacagccacacctcgacccacggcgcgttcggcgcg
ctggccttcggcatcggcacctccgaggtcgagcacgtgctggcgacgcagacgcttccg
ttgcgtcccttcaagaccatggccatcaacatcgagggcacgctgcgcccgggggtcacg
agcaaggacgtgatcctggccgtcatcgccaagatcggcaccggcggcgggcagggctac
gtgctggagtaccggggcagcgccgtcgagaagatgtcgatggaagcccgcatgacgatg
tgcaacatgtcgatcgaggcgggtgcgcgggccggcatgatcgcgcccgacgagaccact
ttcgcctacctgcagggccgtccgcacgccccggagggcacggagtgggacgccgcggtc
gagtactggaagacgcttcgcaccgacgaggacgccgagttcgacgccgaggtgaccctc
gacgccgacgagctgaccccgttcgtcacgtggggcaccaaccccggtcagggcctgccg
ctgggcgctcggatcccggaccccgccgccatcgccgacgagagcgagcgcttcgcgacc
gagaaggcgttggactacatgggcctggaagcgggcactccgctgcgcgaggtggccgtg
gacacggtgttcctcggttcctgcaccaacggccggatcgaagatcttcgggccgcagcg
gacgttctgaagggccgcaaggtggcttcggaggtgcgcatgctggtcgtcccgggctcg
atgagggtccgcaagcaggccgaggccgaggggctcaacgaggttttcaccgccgccggg
gcggaatggcgttcggccggttgttcgatgtgcctgggcatgaaccccgaccagctcacc
cccggggagcgcagcgcgtcgacctccaaccgtaacttcgagggcaggcaaggaaagggc
ggccgcacccacctggtctcgccgctggtggccgccgcgaccgcggtgcgcggcaccctc
tcctcgcccgaagacctcgactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (6)   
   KEGG MODULE (2)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (13)   
   KEGG ENZYME (2)   
   KEGG REACTION (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (6)   
   KEGG ORTHOLOGY (1)   
   RefGene (1)   
   NCBI-PROTEINID (1)   
   CAMBRIDGE (1)   
   KITASATO (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   Pfam (2)   
All databases (53)   

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