KEGG   Salmonella enterica subsp. enterica serovar Typhimurium DT104: DT104_41101
Entry
DT104_41101       CDS       T02874                                 
Symbol
metL
Name
(GenBank) bifunctional aspartokinase II/homoserine dehydrogenase IIcan I write
  KO
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
Organism
send  Salmonella enterica subsp. enterica serovar Typhimurium DT104
Pathway
send00260  Glycine, serine and threonine metabolism
send00261  Monobactam biosynthesis
send00270  Cysteine and methionine metabolism
send00300  Lysine biosynthesis
send01100  Metabolic pathways
send01110  Biosynthesis of secondary metabolites
send01120  Microbial metabolism in diverse environments
send01230  Biosynthesis of amino acids
Module
send_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
send_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
send_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:send00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    DT104_41101 (metL)
   00270 Cysteine and methionine metabolism
    DT104_41101 (metL)
   00300 Lysine biosynthesis
    DT104_41101 (metL)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    DT104_41101 (metL)
Enzymes [BR:send01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     DT104_41101 (metL)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     DT104_41101 (metL)
SSDB
Motif
Pfam: Homoserine_dh AA_kinase NAD_binding_3 HTH_11
Other DBs
NCBI-ProteinID: CCW76808
Position
4387786..4390218
AA seq 810 aa
MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEYSQPDDMMVVSAAGSTTNQLISW
LKLSQTDRLSAHQVLQTLRRYQCDLISGLLPADAADDLTSAFISDLERLAALLDGGVTDA
VYAEIVGHGEIWSARLMSAVLNQQGLDAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLL
AQHPGKRLVVTGFISRNHDGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSDIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDICLIEFQVPASQDFRLAHKELDHILKRAQVRPLAVGVHRDRQLL
QFCYTAEVADSVLKLLDDVGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSEEGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLMLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLNYEGLDASRALAFFDDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASAQLADQYLDFASHGFHVISANKLAGASASDKYRQIHDAFEKTGRYWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT
EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSIDHFFENGDALNE
QMVQRLEAARELGLVLRYVARFDANGKARVGVEAVRPEHPLAALLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq 2433 nt   +upstreamnt  +downstreamnt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcaactgcataaatttggcggcagt
agtctggcggatgtgaagtgttacctgcgtgtcgcaggcattatggcggagtattcgcag
cctgacgatatgatggtagtgtccgccgcaggcagtaccaccaaccagttgattagctgg
ctcaagttaagccagaccgatcgcctttctgcgcatcaggtattacagacgttacgccgc
taccagtgcgatctgattagcgggctgcttcccgccgacgcggcagatgatttaaccagc
gcttttattagcgatctggaacgtcttgccgccttgctcgacggcggcgtaacggatgcc
gtctatgctgagatcgtcggacacggcgaaatttggtcggcgagattgatgtccgccgtc
ctgaatcagcaggggctggatgccgcctggctggacgcgcgcgcatttttacgcgccgaa
cgcgccgcacagccgcaggttgatgaagggctatcttatcctttattgcagcagctactg
gcgcagcatccgggcaaacgtctggtcgtgaccggctttatcagccgcaatcatgacggc
gaaacagtcctgttaggccggaacggttccgactattccgccacgcaaatcggcgcgctg
gcgggcgtttcccgcgtgaccatctggagcgatgtcgcgggcgtttatagcgccgacccg
cgcaaagtgaaagatgcctgcctgctgccgttgctgcgtctggacgaagccagcgagctg
gcgcgtctggcggcgcctgttctgcacgcccgcacgctacagccagtgtccggcagcgat
atcgatttgcagttgcgctgtagctacacgccggatcaagggtcaacccgaattgaacga
gtgctggcttccgggacgggcgcgcgtatcgtgaccagtcacgatgatatctgtctgatt
gagtttcaggtgccagccagccaggatttcaggctggcgcataaagagctcgaccacatt
ttaaaacgggcgcaggtgcgtccgctggcggtgggcgtgcatcgcgatcgccagctattg
cagttctgctataccgccgaggtagcggatagcgtactgaaactcctcgacgatgtcggg
ctgccgggcgaattgcgcctgcgacaggggctggcgctggtggcgatggtcggtgcgggc
gtcactcgcaatccgctacactgccatcgcttctggcagcagttgaaaggtcagccagtg
gagtttacctggcagtcggaggagggcatcagtctggtggcggtgctgcgtaccggccca
actgagagcctgattcaggggctgcatcagtctgttttccgcgccgaaaaacgcattggc
ctgatgctgttcggtaaggggaacatcggctcccgttggctggaactgtttgcccgtgaa
caaagcacgctttccgcgcgtactggttttgaatttgtgctggcgggcgtggtggatagc
cgccgtagcctgttgaattatgaagggctggacgccagccgcgcgttggcattctttgat
gatgaagccgttgagcaggacgaagagtcgctattcctgtggatgcgtgcgcatccgtat
gatgatttagtggtgctggatgtaaccgccagtgcacagttagccgatcagtaccttgat
ttcgccagccacggttttcatgtgattagcgccaataaactggcgggcgcaagcgccagc
gataagtatcgccagattcatgacgcgtttgaaaaaaccgggcgttactggctgtataac
gccaccgtgggcgcgggattgccgatcaaccacacggtgcgggatctgattgacagcggc
gatacgattctctcgatcagcgggatcttctccgggacgctatcctggctgttcctgcaa
tttgacggtacggtgccgttcaccgatctggtggatcaggcctggcagcaggggctgacc
gaacccgatccgcgcgtcgatctttccggaaaagatgtcatgcgtaagctggtgattctg
gcgcgcgaggcgggatacgacatcgagccggatcaggtgcgtgtagaatcgttggtgccg
gcgcattgtgaagaaggatctatcgatcactttttcgaaaacggcgacgcgctgaatgaa
cagatggtgcagcgtctggaggcagcccgcgaactggggctggtgttgcgttacgtggcg
cgtttcgacgccaatggcaaagcgcgcgtcggcgttgaagcggtgcgtccggaacatccg
ctggcggcgctgctgccgtgcgataatgtctttgctattgaaagccgctggtatcgcgat
aacccgctggtgatccgtgggccgggcgcgggtcgcgatgtgaccgccggggcgattcag
tcggatatcaaccgtctggcgcagttgctgtaa

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