KEGG   Shigella flexneri 2457T (serotype 2a): S3729
Entry
S3729             CDS       T00128                                 
Symbol
metL
Name
(GenBank) aspartokinase II and homoserine dehydrogenase II
  KO
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
Organism
sfx  Shigella flexneri 2457T (serotype 2a)
Pathway
sfx00260  Glycine, serine and threonine metabolism
sfx00261  Monobactam biosynthesis
sfx00270  Cysteine and methionine metabolism
sfx00300  Lysine biosynthesis
sfx01100  Metabolic pathways
sfx01110  Biosynthesis of secondary metabolites
sfx01120  Microbial metabolism in diverse environments
sfx01230  Biosynthesis of amino acids
Module
sfx_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
sfx_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
sfx_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:sfx00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    S3729 (metL)
   00270 Cysteine and methionine metabolism
    S3729 (metL)
   00300 Lysine biosynthesis
    S3729 (metL)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    S3729 (metL)
Enzymes [BR:sfx01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     S3729 (metL)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     S3729 (metL)
SSDB
Motif
Pfam: Homoserine_dh AA_kinase NAD_binding_3 HTH_11
Other DBs
NCBI-ProteinID: AAP18749
UniProt: A0A9P2IXI0
Position
complement(3625873..3628305)
AA seq 810 aa
MSVIAQAGAKGRQLHKFGGSSLADVKCYLRVAGIMAEFSQPDDMMVVSAAGSTTNQLINW
LKLSQTDRLSAHQVQQTLRRYQCDLISGLLPAEEADSLISAFVSDLERLAALLDSGINDA
VYAEVVGHGEVWSARLMSAVLNQQGLPAAWLDAREFLRAERAAQPQVDEGLSYPLLQQLL
VQHPSKRLVVTGFISRNNAGETVLLGRNGSDYSATQIGALAGVSRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSGSEIDLQLRCSYTPDQGSTRIER
VLASGTGARIVTSHDDVCLIEFQVPASQDFKLAHKEIDQILKRAQVRPLAVGVHNDRQLL
QFCYTSEVADSALKILDEAGLPGELRLRQGLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSDDGISLVAVLRTGPTESLIQGLHQSVFRAEKRIGLVLFGKGNIGSRWLELFARE
QSTLSARTGFEFVLAGVVDSRRSLLSYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASQQLADQYLDFASHGFHVISANKLAGASDSNKYRQIHDAFEKTGRHWLYN
ATVGAGLPINHTVRDLIDSGDTILSISGIFSGTLSWLFLQFDGSVPFTELVDQAWQQGLT
EPDPRDDLSGKDVMRKLVILAREAGYNIEPDQVRVESLVPAHCEGGSIDHFFENGDELNE
QMVQRLEAAREMGLVLRYVARFDANGKARVGVEAVREDYPLASLLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq 2433 nt   +upstreamnt  +downstreamnt
atgagtgtgattgcgcaggcaggggcgaaaggtcgtcagctgcataaatttggtggcagt
agtctggctgatgtgaagtgttatttgcgtgtcgcgggcattatggcggagttctctcag
cctgacgatatgatggtggtttccgccgccggtagcaccactaaccagttgattaactgg
ttgaaactaagccagaccgatcgtctctctgcgcatcaggttcaacaaacgctgcgtcgc
tatcagtgcgatctgattagcggtctgctacccgctgaagaagccgatagcctcattagc
gcttttgtcagcgatcttgagcgcctggcggcgttgctcgacagtggtattaacgatgcg
gtgtatgcggaagtggtgggccacggtgaagtgtggtcggcgcgcctgatgtctgcggta
cttaatcaacaagggctgccagcggcctggcttgatgcccgtgagtttttacgcgctgaa
cgcgctgcgcaaccgcaggttgatgaagggctttcttacccgttgctgcaacagctactg
gtacaacatccgagcaaacgtctggtggtgaccgggtttatcagccgtaacaacgccggt
gaaacggtgttgctggggcgtaacggttccgactattccgcgacacaaatcggtgcgctg
gcgggtgtttctcgtgtaaccatctggagcgacgtcgccggggtatacagtgccgacccg
cgtaaagtgaaagatgcctgcctgctgccgttgctgcgtctggatgaggccagcgaactg
gcgcgtctggcggctcccgttcttcacgcccgtactttacagccagtttctggcagcgaa
atcgacctgcagctgcgctgtagctacacgccggatcaaggttccacgcgcattgaacgc
gtgctggcctccggtactggtgcgcgtattgtcaccagccacgatgatgtctgtttgatt
gagtttcaggtgcccgccagtcaggatttcaaactggcgcataaagagatcgaccagatc
ctgaaacgtgcccaggtgcgtccactggcggttggcgtgcataacgatcgccagttgttg
caattttgctacacctcagaagtggccgacagtgcgctgaaaatcctcgacgaagcggga
ttacctggagaactgcgcctgcgtcaggggctggcgctggtggcgatggtcggggcgggt
gtcacccgtaacccgctgcattgccaccgcttctggcagcaactgaaaggccagccggtc
gagtttacgtggcagtccgatgacggcatcagtctggtggcagtactgcgcaccggcccg
accgaaagcctgattcaggggctgcatcagtccgtcttccgcgcagaaaaacgcatcggc
ctggtattgttcggcaaaggcaatatcggctctcgctggctggaactgttcgcccgcgag
cagagcacgctttcggcgcgtaccggctttgaatttgtgctggcaggcgtggtggacagc
cgccgcagtctgttgagttatgacgggctggacgccagccgcgcgttagccttcttcaac
gatgaagcggtcgagcaggatgaagagtcgcttttcctgtggatgcgcgcccatccgtat
gatgatttagtggtgttggacgttaccgccagccagcagcttgctgatcagtatctcgat
ttcgccagccacggtttccacgtcatcagtgccaacaaactggcgggagcaagcgacagc
aataaatatcgccagatccacgacgccttcgaaaaaaccgggcgtcactggctatacaac
gccaccgttggtgcgggcttgccgatcaaccataccgtgcgcgatctgatcgacagcggc
gataccattttgtcgatcagtgggatcttctccggcacgctctcctggctgttcctgcaa
ttcgacggtagcgtgccgtttaccgagctggtggatcaggcgtggcagcagggcttaacc
gagcctgatccgcgtgacgacctctccggcaaagacgtaatgcgcaagctggtgattctg
gcgcgtgaagcgggttacaacattgaaccggaccaggtacgtgtggaatcgctggtgcct
gctcattgcgaaggcggcagcatcgaccatttctttgaaaatggcgatgaacttaacgag
cagatggtgcaacggctggaagcggcccgcgaaatggggctggtgctgcgctacgtggcg
cgtttcgatgccaacggcaaagcgcgtgtgggcgtggaggcggtgcgtgaagactatccg
ctggcatcactgctgccatgcgataacgtctttgccatcgaaagccgctggtaccgcgat
aatccgctggtgatccgtgggcctggcgctgggcgcgacgtcaccgccggggcgattcag
tcggatatcaaccggctggcacagttgttgtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (8)   
   KEGG MODULE (5)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (4)   
   Pfam (4)   
All databases (40)   

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