KEGG   Sarcophilus harrisii (Tasmanian devil): 100927125
Entry
100927125         CDS       T02286                                 
Symbol
TLR4
Name
(RefSeq) toll-like receptor 4
  KO
K10160  toll-like receptor 4
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr04064  NF-kappa B signaling pathway
shr04066  HIF-1 signaling pathway
shr04145  Phagosome
shr04151  PI3K-Akt signaling pathway
shr04217  Necroptosis
shr04613  Neutrophil extracellular trap formation
shr04620  Toll-like receptor signaling pathway
shr04621  NOD-like receptor signaling pathway
shr04936  Alcoholic liver disease
shr05132  Salmonella infection
shr05133  Pertussis
shr05134  Legionellosis
shr05135  Yersinia infection
shr05140  Leishmaniasis
shr05142  Chagas disease
shr05144  Malaria
shr05145  Toxoplasmosis
shr05146  Amoebiasis
shr05152  Tuberculosis
shr05161  Hepatitis B
shr05162  Measles
shr05164  Influenza A
shr05170  Human immunodeficiency virus 1 infection
shr05171  Coronavirus disease - COVID-19
shr05205  Proteoglycans in cancer
shr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
shr05321  Inflammatory bowel disease
shr05323  Rheumatoid arthritis
shr05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:shr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    100927125 (TLR4)
   04066 HIF-1 signaling pathway
    100927125 (TLR4)
   04151 PI3K-Akt signaling pathway
    100927125 (TLR4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    100927125 (TLR4)
  09143 Cell growth and death
   04217 Necroptosis
    100927125 (TLR4)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    100927125 (TLR4)
   04620 Toll-like receptor signaling pathway
    100927125 (TLR4)
   04621 NOD-like receptor signaling pathway
    100927125 (TLR4)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    100927125 (TLR4)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    100927125 (TLR4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    100927125 (TLR4)
   05161 Hepatitis B
    100927125 (TLR4)
   05171 Coronavirus disease - COVID-19
    100927125 (TLR4)
   05164 Influenza A
    100927125 (TLR4)
   05162 Measles
    100927125 (TLR4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    100927125 (TLR4)
   05135 Yersinia infection
    100927125 (TLR4)
   05133 Pertussis
    100927125 (TLR4)
   05134 Legionellosis
    100927125 (TLR4)
   05152 Tuberculosis
    100927125 (TLR4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    100927125 (TLR4)
   05144 Malaria
    100927125 (TLR4)
   05145 Toxoplasmosis
    100927125 (TLR4)
   05140 Leishmaniasis
    100927125 (TLR4)
   05142 Chagas disease
    100927125 (TLR4)
  09163 Immune disease
   05323 Rheumatoid arthritis
    100927125 (TLR4)
   05321 Inflammatory bowel disease
    100927125 (TLR4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    100927125 (TLR4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    100927125 (TLR4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:shr04131]
    100927125 (TLR4)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:shr04054]
    100927125 (TLR4)
   04090 CD molecules [BR:shr04090]
    100927125 (TLR4)
   00536 Glycosaminoglycan binding proteins [BR:shr00536]
    100927125 (TLR4)
Membrane trafficking [BR:shr04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    100927125 (TLR4)
Pattern recognition receptors [BR:shr04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   100927125 (TLR4)
CD molecules [BR:shr04090]
 Proteins
  100927125 (TLR4)
Glycosaminoglycan binding proteins [BR:shr00536]
 Hyaluronan
  Cell surface receptors
   100927125 (TLR4)
SSDB
Motif
Pfam: LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_5 LRR_9 ThsB_TIR
Other DBs
NCBI-GeneID: 100927125
NCBI-ProteinID: XP_003757124
Ensembl: ENSSHAG00000017208
UniProt: G3WXY5
Position
2:439946977..439958700
AA seq 828 aa
MVRWIAMALIITTTFFSCLDPGSCHSCLEVFPDIEYQCMARNFSEVPVDIPSSTQKLDLS
FNPLKSLASRSFSRFTGLRILDLSRCDIQKIEDDTYQGLCNLSTLILTGNPIQSLGLRAF
HGLPKLQKLVVVETNLVSLKDFPIGHLMTLQELYLGHNSISSLKLPHYFASFSSLQHLDL
HLNLINNISDGDLEPIKMNLNLTLDLSQNPIQYIHPGVLKGIHLTGLILRGNFHSSAVME
VCIKGMTGLQVNKLVLGNYKNEFQMTNFESKILDGLCQVDIDEFWMVVPSDFPSDSYGFF
RCLVNVSVLHMVTVPLEVLTNLPVFPKLFSLVFTNCKFETLPTLPSTSLPSLKELRITRH
KDLTTLSDLKLPSLELLDLSQNALNILSCCSYNNFDTDKLKYLNLSYNAQIMLSKNFMGF
ENLESLDLQHCQLKGHNNFPVFLSLTKLQYLDISYTNTHVQFENIFAGLSNLRHLKMAGN
FFQGNILQDIFKNLSQLVTLNISYCHLEKIPQITMKSLHQLQVLDISHNNLQTFEPLIFR
PLWNLQVLNCSYNSITALDGQNLQSLSETLVSTDFSGNPFDCVCDHQIFFQWVKENIQLL
NRSKPMICQTPSHMKDVSVLLFDDLYCQMKKTIIAMSILAIMLVLMALALVYKFYFHLML
LAGCKKMVGEESTYDAFVIYSSQDEEWVRKELVKNLEEGVPSFQLCLHYRDFIPGVAIAA
NIIQEGFHKSRKVIVVISKHFIQSRWCKFEYEIAQTWQFLSSHAGIIFIMLQKVEKSLLR
QQVELYRLLRRNTYLEWENTNLGRHVFWRRLRKALLDGRTKRQKEAAE
NT seq 2487 nt   +upstreamnt  +downstreamnt
atggtccgttggatagccatggctctgattataaccacaaccttcttttcctgtctggat
ccggggagttgtcattcctgcctagaggtttttccagacattgaataccaatgcatggcc
cgaaatttctctgaagttccagtggatataccttcatccacccagaagctggacctgagc
ttcaacccactgaagtctttggcttcacgaagtttttccagatttactggactgagaata
cttgacttgtccagatgtgatattcagaagattgaggatgacacttatcaaggcctctgt
aatctctctactttgatcctgacgggaaacccaatccagagtttgggtctcagagccttc
catggtcttcccaagttacagaagctggttgttgtagaaacaaatcttgtgtctctgaag
gacttccccattggacatctcatgaccctgcaggagctatatttaggacataattccatc
agttctctcaagttaccccattattttgccagtttcagctccctgcagcatctggatctt
cacttgaatttgataaataatatttctgatggagatttagagcctataaagatgaatcta
aatctcactctagacctttctcagaatcctattcaatatatccatccaggcgtcttaaag
gggattcacttaactggactaattctgagaggaaattttcacagttcagcagtcatggag
gtttgtattaagggaatgactggcttgcaagtcaacaaactggttcttggaaattacaaa
aatgaattccaaatgactaactttgagagcaagatcctagatgggttgtgtcaggtggac
attgatgaattttggatggttgttccctctgattttccttcagatagttatggatttttc
agatgtttagtcaatgtttctgttctccatatggttacggttcccttagaagtgctgact
aacctaccagtatttcctaaactgttctcattggtattcactaactgcaaatttgaaaca
ctgcctaccttaccatctacctctctcccctcccttaaagaacttcgtattactcgccac
aaagatctcacaactttgtctgatttgaaacttcccagtctggagcttctggacctcagt
caaaatgctctgaatattttgtcctgctgttcctacaataactttgatacagacaaactg
aaatatttgaacttaagttataatgctcaaatcatgttgagtaagaacttcatgggtttt
gaaaacctagaatctctggatcttcaacattgccaattgaaaggtcataacaatttccct
gtctttttatcactcacaaaacttcagtacctggatatttcttatacaaacactcatgtc
caatttgaaaatatttttgcaggtttgagcaatttaagacatttgaaaatggctggtaac
tttttccagggcaacattttacaagacatcttcaagaatctgagtcagcttgtcacacta
aatatttcctactgtcacctagaaaaaatcccccaaataacaatgaagtccctccatcaa
ctccaggtgttggatattagccataacaacctccagacttttgaaccactcattttcagg
cctctttggaacctccaagtcttgaactgcagttacaacagtatcacagccctggatggg
cagaatttacagtcattgtcagaaactctggtttctactgatttttctggaaatcccttt
gattgtgtctgtgaccatcaaatcttctttcagtgggtcaaagagaatatacaactcttg
aatagatctaaaccaatgatttgccagacaccttctcatatgaaagatgtctctgtgcta
ttatttgatgatttatattgtcagatgaaaaagactatcattgctatgtcaattttggca
ataatgttggtacttatggcactggccttggtctataagttctatttccacctgatgctg
cttgctggctgcaaaaaaatggttggagaggaaagcacttatgatgcttttgtgatctat
tctagtcaagatgaggaatgggtgaggaaggaattggtgaaaaacctagaagagggtgtt
ccctcattccaactctgcctccactaccgagactttatccctggtgtggctattgctgcc
aacattattcaggaaggtttccataagagtcggaaggtcattgttgtgatctccaagcac
tttatccagagccgctggtgcaagtttgagtatgaaattgctcagacatggcagttcctg
agcagtcacgcaggtatcatcttcatcatgctacagaaagtggaaaaatcactactgcga
caacaggtggaactctaccggctgcttcgtcgaaacacctacctggaatgggagaacact
aacctgggtagacatgtgttttggagacggctgagaaaagcattgttagatggcagaaca
aagaggcagaaagaagcagctgaataa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (29)   
   KEGG PATHWAY (29)   
Genome (1)   
   KEGG GENOME (1)   
Gene (24)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (70)   

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