KEGG   Sarcophilus harrisii (Tasmanian devil): 100930689
Entry
100930689         CDS       T02286                                 
Symbol
PDHA1
Name
(RefSeq) pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X2
  KO
K00161  pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]
Organism
shr  Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00010  Glycolysis / Gluconeogenesis
shr00020  Citrate cycle (TCA cycle)
shr00620  Pyruvate metabolism
shr00785  Lipoic acid metabolism
shr01100  Metabolic pathways
shr01200  Carbon metabolism
shr01210  2-Oxocarboxylic acid metabolism
shr04066  HIF-1 signaling pathway
shr04922  Glucagon signaling pathway
shr05230  Central carbon metabolism in cancer
shr05415  Diabetic cardiomyopathy
Module
shr_M00307  Pyruvate oxidation, pyruvate => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:shr00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    100930689 (PDHA1)
   00020 Citrate cycle (TCA cycle)
    100930689 (PDHA1)
   00620 Pyruvate metabolism
    100930689 (PDHA1)
  09108 Metabolism of cofactors and vitamins
   00785 Lipoic acid metabolism
    100930689 (PDHA1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    100930689 (PDHA1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    100930689 (PDHA1)
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    100930689 (PDHA1)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    100930689 (PDHA1)
Enzymes [BR:shr01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.4  With a disulfide as acceptor
    1.2.4.1  pyruvate dehydrogenase (acetyl-transferring)
     100930689 (PDHA1)
SSDB
Motif
Pfam: E1_dh DXP_synthase_N TPP_enzyme_C
Other DBs
NCBI-GeneID: 100930689
NCBI-ProteinID: XP_003763559
Ensembl: ENSSHAG00000015375
UniProt: G3WRQ6
Position
3:complement(275114444..275145639)
AA seq 390 aa
MRKMLAVVSRVLTGASQKPVGRVLLASRNFANDATFDIKKCDIHRLEEGPPTTAVLTREE
GLKYYKIMQTVRRMELKADQLYKQKIIRGFCHLYDGQEACCMGLEAGINPTDHVITAYRA
HGFTYTRGLPVREILAELTGRRGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNEKDEICLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGIRVDGMDVLCVREATKFAAAYCRSGKGPMLMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNNNLASIEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSRDPPFEVRGANQWIKYKSVS
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgcgaaaaatgctcgccgtcgtttcccgcgtgctgacgggcgcctcccagaaaccggtt
ggaagagtgctactggcatcccgtaactttgcaaatgatgctacctttgatattaagaaa
tgtgacattcatcggcttgaggaaggccctcccaccacagcagttctcactagagaggaa
ggactcaaatactataagatcatgcagactgtccgtcggatggaattgaaagcagaccag
ctatataagcaaaagattatccgtgggttttgccacttgtatgatggacaggaagcttgt
tgtatggggcttgaagctggcataaatcctacagatcatgttattacagcctatcgagct
catggctttacatatactcgtggacttcctgttcgagaaattttggcagagcttacagga
agaagagggggatgtgctaaaggaaagggaggatctatgcacatgtacgccaagaacttc
tacggcggcaatggcattgttggagctcaggtacctctaggagctggtattgccctcgcc
tgtaagtacaatgaaaaagatgagatttgtttgactttgtatggagatggtgctgctaat
cagggtcagatatttgaagcttacaatatggcagctttgtggaaattgccttgtattttc
atttgtgagaataaccgatatggaatgggaacttctgtagagagagcagcagccagcact
gactattacaaaagaggggactttattccaggaataagggtagatggtatggatgttctg
tgtgttcgtgaagcaacaaaatttgcagctgcctactgtagatcaggaaagggccccatg
ttgatggaactacagacatatcgttatcacggacacagcatgagtgatcctggtgtcagt
tatcgcactcgggaagaaattcaggaagtgaggagtaagagtgatcctatcatgcttcta
aaagacagaatggtgaacaacaatcttgccagtattgaagaattaaaggaaattgatgtt
gaagtaaggaaagagattgaggatgctgcccagtttgctacagcggatccagaaccacct
ttggaagaattaggctatcatatctactccagagatccaccttttgaagttcgaggagca
aatcagtggatcaagtacaaatctgtcagctaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (12)   
   KEGG PATHWAY (11)   
   KEGG MODULE (1)   
Chemical substance (11)   
   KEGG COMPOUND (11)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (4)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   RefSeq(pep) (3)   
DNA sequence (3)   
   RefSeq(nuc) (3)   
Protein domain (3)   
   Pfam (3)   
All databases (60)   

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