KEGG   PATHWAY: slt00910Help
slt00910                    Pathway                                

Nitrogen metabolism - Sideroxydans lithotrophicus
The biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in nitrate to -3 in ammonia. The core nitrogen cycle involves four reduction pathways and two oxidation pathways. Nitrogen fixation [MD:M00175] is the process of reducing atmospheric molecular nitrogen to ammonia, a biologically useful reduced form incorporated into amino acids and other vital compounds. The ability of fixing atmospheric nitrogen by the nitrogenase enzyme complex is present in restricted prokaryotes (diazotrophs). The other reduction pathways are assimilatory nitrate reduction [MD:M00531] and dissimilatory nitrate reduction [MD:M00530] both for conversion to ammonia, and denitrification [MD:M00529]. Denitrification is a respiration in which nitrate or nitrite is reduced as a terminal electron acceptor under low oxygen or anoxic conditions, producing gaseous nitrogen compounds (N2, NO and N2O) to the atmosphere. The two oxidation pathways are nitrification [MD:M00528] and anaerobic ammonium oxidation (anammox). Nitrification is the oxidation of ammonia (NH3) with oxygen into nitrite followed by the oxidation of nitrite into nitrate. The first step is performed by ammonia-oxidizing microorganisms (e.g., Nitrosomonas and Nitrosococcus) and the second step by nitrite-oxidizing microorganisms (e.g., Nitrobacter). Anammox is a biochemical process of oxidizing ammonium (NH4+) into dinitrogen gas (N2) using nitrite as an electron acceptor. It occurs in the anammoxosome, a membrane bound compartment inside the cytoplasm, of anammox bacteria (e.g., Planctomycetes).
Metabolism; Energy metabolism
BRITE hierarchy
Pathway map
slt00910  Nitrogen metabolism

Ortholog table
slt_M00175  Nitrogen fixation, nitrogen => ammonia [PATH:slt00910]
slt_M00438  Nitrate/nitrite transport system [PATH:slt00910]
Other DBs
BSID: 146212
GO: 0006807
Sideroxydans lithotrophicus [GN:slt]
Slit_0155  nitrate transport ATP-binding protein [KO:K15576]
Slit_0156  binding-protein-dependent transport systems inner membrane component [KO:K15577]
Slit_0157  nitrate ABC transporter, ATPase subunits C and D [KO:K15578] [EC:3.6.3.-]
Slit_0160  molybdopterin oxidoreductase [KO:K00372] [EC:1.7.99.-]
Slit_0158  nitrite reductase (NAD(P)H), large subunit [KO:K00362] [EC:]
Slit_0159  nitrite reductase (NAD(P)H), small subunit [KO:K00363] [EC:]
Slit_1129  Nitrite reductase (NO-forming) [KO:K15864] [EC:]
Slit_1122  Nitric-oxide reductase [KO:K04561] [EC:]
Slit_1121  cytochrome c class I [KO:K02305]
Slit_0882  nitrogenase molybdenum-iron protein alpha chain [KO:K02586] [EC:]
Slit_0883  nitrogenase molybdenum-iron protein beta chain [KO:K02591] [EC:]
Slit_0881  nitrogenase iron protein [KO:K02588] [EC:]
Slit_2923  glutamine synthetase, type I [KO:K01915] [EC:]
Slit_0094  glutamine synthetase, type III [KO:K01915] [EC:]
Slit_0115  Glutamate synthase (ferredoxin) [KO:K00265] [EC:]
Slit_0116  glutamate synthase, NADH/NADPH, small subunit [KO:K00266] [EC:]
Slit_0028  Carbonate dehydratase [KO:K01673] [EC:]
C00011  CO2
C00014  Ammonia
C00025  L-Glutamate
C00058  Formate
C00064  L-Glutamine
C00088  Nitrite
C00169  Carbamoyl phosphate
C00192  Hydroxylamine
C00244  Nitrate
C00288  HCO3-
C00488  Formamide
C00533  Nitric oxide
C00697  Nitrogen
C00726  Nitrile
C00887  Nitrous oxide
C01417  Cyanate
C01563  Carbamate
C05361  Hydrazine
C06058  Nitroalkane
Scott JD, Ludwig RA
Azorhizobium caulinodans electron-transferring flavoprotein N electrochemically couples pyruvate dehydrogenase complex activity to N2 fixation.
Microbiology 150:117-26 (2004)
Kneip C, Lockhart P, Voss C, Maier UG
Nitrogen fixation in eukaryotes--new models for symbiosis.
BMC Evol Biol 7:55 (2007)
Whittaker M, Bergmann D, Arciero D, Hooper AB
Electron transfer during the oxidation of ammonia by the chemolithotrophic bacterium Nitrosomonas europaea.
Biochim Biophys Acta 1459:346-55 (2000)
Cabello P, Roldan MD, Moreno-Vivian C
Nitrate reduction and the nitrogen cycle in archaea.
Microbiology 150:3527-46 (2004)
Stolz JF, Basu P
Evolution of nitrate reductase: molecular and structural variations on a common function.
Morozkina EV, Zvyagilskaya RA
Nitrate reductases: structure, functions, and effect of stress factors.
Biochemistry (Mosc) 72:1151-60 (2007)
Jetten MS, Niftrik L, Strous M, Kartal B, Keltjens JT, Op den Camp HJ
Biochemistry and molecular biology of anammox bacteria.
Crit Rev Biochem Mol Biol 44:65-84 (2009)
Luesken FA, Wu ML, Op den Camp HJ, Keltjens JT, Stunnenberg H, Francoijs KJ, Strous M, Jetten MS
Effect of oxygen on the anaerobic methanotroph 'Candidatus Methylomirabilis oxyfera': kinetic and transcriptional analysis.
Environ Microbiol 14:1024-34 (2012)
Daims H, Lebedeva EV, Pjevac P, Han P, Herbold C, Albertsen M, Jehmlich N, Palatinszky M, Vierheilig J, Bulaev A, Kirkegaard RH, von Bergen M, Rattei T, Bendinger B, Nielsen PH, Wagner M
Complete nitrification by Nitrospira bacteria.
Nature 528:504-9 (2015)
van Kessel MA, Speth DR, Albertsen M, Nielsen PH, Op den Camp HJ, Kartal B, Jetten MS, Lucker S
Complete nitrification by a single microorganism.
Nature 528:555-9 (2015)
KO pathway

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