KEGG   PATHWAY: sma00290
Entry
sma00290                    Pathway                                

Name
Valine, leucine and isoleucine biosynthesis - Streptomyces avermitilis
Class
Metabolism; Amino acid metabolism
Pathway map
sma00290  Valine, leucine and isoleucine biosynthesis
sma00290

Module
sma_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sma00290]
sma_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sma00290]
sma_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sma00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_3302  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SAVERM_2686  leuC; putative 3-isopropylmalate dehydratase subunit large [KO:K01703] [EC:4.2.1.33 4.2.1.35]
SAVERM_2685  leuD; putative 3-isopropylmalate dehydratase subunit small [KO:K01704] [EC:4.2.1.33 4.2.1.35]
SAVERM_2718  leuB; putative 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
SAVERM_2733  ilvB1; acetolactate synthase subunit large [KO:K01652] [EC:2.2.1.6]
SAVERM_5286  ilvB4; putative acetolactate synthase [KO:K01652] [EC:2.2.1.6]
SAVERM_1819  ilvB3; putative TPP-requiring enzyme (acetolactate synthase II) [KO:K01652] [EC:2.2.1.6]
SAVERM_2732  ilvN; acetolactate synthase subunit small [KO:K01653] [EC:2.2.1.6]
SAVERM_2731  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
SAVERM_4716  ilvD1; putative dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
SAVERM_6804  putative D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_842  ilvE2; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_2717  ilvE; putative branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SAVERM_2008  aspB1; putative aspartate aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
SAVERM_3285  aspB3; putative aspartate aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
SAVERM_5601  leuA2; putative 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
SAVERM_2710  leuA1; putative 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
sma00260  Glycine, serine and threonine metabolism
sma00280  Valine, leucine and isoleucine degradation
sma00620  Pyruvate metabolism
KO pathway
ko00290   

DBGET integrated database retrieval system