KEGG   PATHWAY: sma00362
Entry
sma00362                    Pathway                                

Name
Benzoate degradation - Streptomyces avermitilis
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
sma00362  Benzoate degradation
sma00362

Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_1968  pcaL2; putative 3-oxoadipate enol-lactone hydrolase [KO:K14727] [EC:3.1.1.24 4.1.1.44]
SAVERM_1706  pcaL1; putative 3-oxoadipate enol-lactone hydrolase [KO:K14727] [EC:3.1.1.24 4.1.1.44]
SAVERM_5866  ltp1; putative lipid-transfer protein [KO:K00632] [EC:2.3.1.16]
SAVERM_7026  fadA6; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_1604  pcaF1; putative beta-ketoadipyl-CoA thiolase [KO:K00632] [EC:2.3.1.16]
SAVERM_2233  fadA8; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00632] [EC:2.3.1.16]
SAVERM_1615  xylE; putative catechol 2,3-dioxygenase [KO:K00446] [EC:1.13.11.2]
SAVERM_1704  pcaG; putative protocatechuate 3,4-dioxygenase alpha subunit [KO:K00448] [EC:1.13.11.3]
SAVERM_1703  pcaH; putative protocatechuate 3,4-dioxygenase beta subunit [KO:K00449] [EC:1.13.11.3]
SAVERM_1705  pcaB; putative 3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
SAVERM_6757  putative carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
SAVERM_1616  putative transmenmbrane protein [KO:K16514] [EC:5.3.2.8]
SAVERM_1618  hypothetical protein [KO:K16515] [EC:4.2.1.83]
SAVERM_1617  putative dimethylmenaquinone methyltransferase family protein [KO:K10218] [EC:4.1.3.17]
SAVERM_3517  pobA; putative p-hydroxybenzoate hydroxylase [KO:K00481] [EC:1.14.13.2]
SAVERM_3841  fadD17; putative cyclohex-1-ene-1-carboxylate:CoA ligase [KO:K04116] [EC:6.2.1.-]
SAVERM_1680  fadB1; putative fatty acid oxidation complex alpha-subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
SAVERM_6542  fadE12; putative acyl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
SAVERM_1347  gcdH2; putative glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
SAVERM_719  gcdH1; putative glutaryl-CoA dehydrogenase [KO:K00252] [EC:1.3.8.6]
SAVERM_1245  echA4; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_717  echA3; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_7216  echA15; putative enoyl-CoA hydratase/isomerase family protein [KO:K01692] [EC:4.2.1.17]
SAVERM_3863  echA12; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_6203  echA13; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_1350  echA5; putative enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SAVERM_2870  fadC3; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_4359  paaH; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_6748  fadC5; putative 3-hydroxyacyl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
SAVERM_1384  fadA5; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_2856  fadA1; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1681  fadA4; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_1242  putative nonspecific lipid-transfer protein [KO:K00626] [EC:2.3.1.9]
SAVERM_5842  fadA7; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_3512  fadA2; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SAVERM_6199  fadA3; putative 3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  6-Carboxyhexanoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohex-2,5-diene-1-carboxyl-CoA
C09810  Cyclohex-1,4-diene-1-carboxyl-CoA
C09811  Cyclohex-1-ene-1-carboxyl-CoA
C09812  2-Hydroxycyclohexane-1-carboxyl-CoA
C09813  2-Ketocyclohexane-1-carboxyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carboxyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
sma00010  Glycolysis / Gluconeogenesis
sma00020  Citrate cycle (TCA cycle)
sma00350  Tyrosine metabolism
sma00360  Phenylalanine metabolism
sma00361  Chlorocyclohexane and chlorobenzene degradation
sma00627  Aminobenzoate degradation
sma00790  Folate biosynthesis
KO pathway
ko00362   

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