KEGG   PATHWAY: sma03018Help
Entry
sma03018                    Pathway                                

Name
RNA degradation - Streptomyces avermitilis
Description
The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex.
Class
Genetic Information Processing; Folding, sorting and degradation
BRITE hierarchy
Pathway map
sma03018  RNA degradation
sma03018

Ortholog table
Other DBs
GO: 0006401
Organism
Streptomyces avermitilis [GN:sma]
Gene
SAVERM_5465  hypothetical protein [KO:K08300] [EC:3.1.26.12]
SAVERM_3533  eno; putative enolase [KO:K01689] [EC:4.2.1.11]
SAVERM_2523  pnp; putative guanosine pentaphosphate synthetase/polyribonucleotide nucleotidyltransferase [KO:K00962] [EC:2.7.7.8]
SAVERM_4851  recQ; putative ATP-dependent DNA helicase [KO:K03654] [EC:3.6.4.12]
SAVERM_2450  putative ATP-dependent DNA helicase [KO:K03654] [EC:3.6.4.12]
SAVERM_1310  rho2; putative transcription termination factor [KO:K03628]
SAVERM_2915  rho1; putative transcription termination factor Rho [KO:K03628]
SAVERM_2515  putative hydrolase of the metallo-beta-lactamase superfamily [KO:K12574] [EC:3.1.-.-]
SAVERM_4484  dnaK1; putative heat shock protein Hsp70 [KO:K04043]
SAVERM_7237  dnaK2; putative heat shock protein Hsp70 [KO:K04043]
SAVERM_3931  groEL2; putative class I heat-shock protein [KO:K04077]
SAVERM_4992  groEL1; putative class I heat-shock protein [KO:K04077]
SAVERM_4069  ppk; putative polyphosphate kinase [KO:K00937] [EC:2.7.4.1]
SAVERM_1274  pvdS; putative regulatory protein [KO:K22468] [EC:2.7.4.1]
SAVERM_4299  pcnA; putative RNA nucleotidyltransferase [KO:K00970] [EC:2.7.7.19]
Reference
  Authors
Houseley J, Tollervey D
  Title
The many pathways of RNA degradation.
  Journal
Cell 136:763-76 (2009)
DOI:10.1016/j.cell.2009.01.019
Reference
  Authors
Buttner K, Wenig K, Hopfner KP
  Title
The exosome: a macromolecular cage for controlled RNA degradation.
  Journal
Mol Microbiol 61:1372-9 (2006)
DOI:10.1111/j.1365-2958.2006.05331.x
Reference
  Authors
Schilders G, van Dijk E, Raijmakers R, Pruijn GJ
  Title
Cell and molecular biology of the exosome: how to make or break an RNA.
  Journal
Int Rev Cytol 251:159-208 (2006)
DOI:10.1016/S0074-7696(06)51005-8
Reference
  Authors
Hartung S, Hopfner KP
  Title
The exosome, plugged.
  Journal
EMBO Rep 8:456-7 (2007)
DOI:10.1038/sj.embor.7400961
Reference
  Authors
Carpousis AJ
  Title
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
  Journal
Annu Rev Microbiol 61:71-87 (2007)
DOI:10.1146/annurev.micro.61.080706.093440
Reference
  Authors
Marcaida MJ, DePristo MA, Chandran V, Carpousis AJ, Luisi BF
  Title
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
  Journal
Trends Biochem Sci 31:359-65 (2006)
DOI:10.1016/j.tibs.2006.05.005
Reference
  Authors
Condon C
  Title
Maturation and degradation of RNA in bacteria.
  Journal
Curr Opin Microbiol 10:271-8 (2007)
DOI:10.1016/j.mib.2007.05.008
KO pathway
ko03018   

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