KEGG   Streptomyces avermitilis: SAVERM_2710
Entry
SAVERM_2710       CDS       T00126                                 
Symbol
leuA1
Name
(GenBank) putative 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
sma  Streptomyces avermitilis
Pathway
sma00290  Valine, leucine and isoleucine biosynthesis
sma00620  Pyruvate metabolism
sma01100  Metabolic pathways
sma01110  Biosynthesis of secondary metabolites
sma01210  2-Oxocarboxylic acid metabolism
sma01230  Biosynthesis of amino acids
Module
sma_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:sma00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    SAVERM_2710 (leuA1)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    SAVERM_2710 (leuA1)
Enzymes [BR:sma01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     SAVERM_2710 (leuA1)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer URO-D HNHc_6
Other DBs
NCBI-ProteinID: BAC70421
NITE: SAV2710
UniProt: Q82JP4
Position
complement(3323914..3325518)
AA seq 534 aa
MTETSELDDSFHVFDTTLRDGAQREGINLTVADKLAIARHLDDFGVGFIEGGWPGANPRD
TEFFARAQQEIDFKHAQLVAFGATRRAGAKASEDPQVKALLEAGAQVITLVAKSHDRHVE
LALRTTLDENLEMVRDTVSYLCSQGRRVFVDCEHFFDGYRANPEYAKAVVRAAAEAGADV
VVLCDTNGGMLPAQVQAVVATVLADTGARLGIHAQDDTGCAVANTLAAVDAGATHVQCTA
NGYGERVGNSNLFPVVAALELKYGKKVLPEGALREMTRISHAIAEVVNLTPSTHQPYVGV
SAFAHKAGLHASAIKVDPDLYQHIDPERVGNTMRMLVSDMAGRASIELKGKELGVDISGD
RELVGRVVERVKERELKGYTYEAADASFELLLRAEAEGKARTYFEVESWRAIVEDRPDGT
HANEATVKLFAKGERIVATAEGNGPVNALDRALRVALEMIYPQLAKLELVDYKVRILEGK
HGTSSTTRVLISTSDGTGEWSTVGVAENVIAASWQALEDAYTYGLLRAGVEPAE
NT seq 1605 nt   +upstreamnt  +downstreamnt
atgacggaaaccagcgaactcgacgattcgttccacgtcttcgacacgaccctgcgcgac
ggcgcacagcgcgagggcattaacctcacggtcgccgacaagctggccatcgcacggcac
ctggacgacttcggcgtgggcttcatcgagggcggctggcccggcgccaacccgcgggac
accgagttcttcgcccgcgcccagcaggagatcgacttcaagcacgcccagctggtggcc
ttcggagccacgcgccgcgcgggcgccaaggcgagcgaggacccgcaggtcaaggcgctg
ctggaggcgggcgcccaggtgatcaccctggtcgccaagtcgcacgaccgccatgtcgaa
ctggctctgcgcacgacgctcgacgagaacctggagatggtccgcgacacggtctcgtac
ctgtgctcccaggggcgccgggtcttcgtcgactgtgagcacttcttcgacggttaccgg
gcgaacccggagtacgcgaaggcggtcgtacgggccgcggccgaggccggcgccgatgtg
gtcgtgctctgcgacaccaacggcggcatgctccccgcccaggtccaggcggtcgtcgcc
acggtcctcgcggacaccggtgcccggctcggcatccacgcccaggacgacacgggctgc
gcggtggcgaacacgctggccgcggtggacgcgggcgcgacccatgtgcagtgcacggcg
aacgggtacggcgagcgggtcggcaactccaacctgttcccggtggtggcggccctggag
ctgaagtacggcaagaaggtgctccccgaaggcgcgctgcgcgagatgacgaggatctcg
cacgcgatcgccgaggtcgtgaacctcaccccctccacgcaccagccgtacgtcggtgtc
tcggccttcgcgcacaaggcgggcctgcacgcctccgcgatcaaggtcgacccggacctg
taccagcacatcgaccccgagcgggtcggcaacaccatgcggatgctggtgtccgacatg
gcgggccgcgcctccatcgagctcaagggcaaggagctcggcgtcgacatcagcggcgac
cgcgagctggtcggccgggtcgtggagcgggtgaaggagcgcgagctcaagggctacacg
tacgaggcggcggacgcgagcttcgaactcctgctgcgcgcggaggcggagggcaaggcc
cgcacgtacttcgaggtcgagtcctggcgggcgatcgtcgaggaccgcccggacggcacc
cacgccaacgaggccacggtcaagctcttcgccaagggcgagcggatcgtcgccaccgcc
gagggcaacggcccggtcaacgccctcgaccgggccctgcgcgtcgccctcgaaatgatc
tacccccagctcgccaagctggagctggtggactacaaggtccgcatcctggagggcaag
cacggcacgtcctccacgacccgcgtgctcatctccacctccgacggcaccggtgaatgg
tcgacggtcggtgtcgcggagaacgtgatcgccgcgtcctggcaggccctggaggacgcc
tacacgtacggcctgctgcgggccggcgtggagccggccgagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NITE (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (4)   
   Pfam (4)   
All databases (26)   

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