KEGG   PATHWAY: smal00280
Entry
smal00280                   Pathway                                

Name
Valine, leucine and isoleucine degradation - Streptomyces malaysiensis
Class
Metabolism; Amino acid metabolism
Pathway map
smal00280  Valine, leucine and isoleucine degradation
smal00280

Module
smal_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:smal00280]
Other DBs
GO: 0006550 0006552 0006574
Organism
Streptomyces malaysiensis [GN:smal]
Gene
SMALA_5499  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SMALA_6473  D-alanine aminotransferase [KO:K00826] [EC:2.6.1.42]
SMALA_4135  Glu/Leu/Phe/Val dehydrogenase dimerization region [KO:K00271] [EC:1.4.1.23]
SMALA_2103  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SMALA_7386  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
SMALA_1605  putative acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SMALA_2805  acyl-CoA dehydrogenase [KO:K00249] [EC:1.3.8.7]
SMALA_6591  acyl-CoA dehydrogenase type 2 [KO:K00249] [EC:1.3.8.7]
SMALA_2810  acyl-CoA dehydrogenase [KO:K11410] [EC:1.3.99.12]
SMALA_7393  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SMALA_0722  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SMALA_1309  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SMALA_0595  putative enoyl-CoA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
SMALA_3404  hypothetical protein [KO:K01692] [EC:4.2.1.17]
SMALA_7143  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SMALA_0831  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
SMALA_6310  fatty oxidation complex alpha subunit [KO:K01782] [EC:1.1.1.35 4.2.1.17 5.1.2.3]
SMALA_5889  acetyl-coa acetyltransferase (thiolase) [KO:K00632] [EC:2.3.1.16]
SMALA_3407  putative acetyl/propionyl-CoA carboxylase alpha subunit [KO:K01965] [EC:6.4.1.3]
SMALA_3230  propionyl-CoA carboxylase beta [KO:K01966] [EC:6.4.1.3 2.1.3.15]
SMALA_2808  acetyl/propionyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SMALA_3235  acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SMALA_1298  acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SMALA_2896  acyl-CoA carboxylase, alpha subunit [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
SMALA_5344  glyoxalase/bleomycin resistance protein/dioxygenase [KO:K05606] [EC:5.1.99.1]
SMALA_7091  methylmalonyl-CoA mutase, beta subunit [KO:K01847] [EC:5.4.99.2]
SMALA_7092  methylmalonyl-CoA mutase large subunit [KO:K01847] [EC:5.4.99.2]
SMALA_1329  cobalamin B12-binding domain protein [KO:K01849] [EC:5.4.99.2]
SMALA_3350  cobalamin B12-binding domain protein [KO:K01849] [EC:5.4.99.2]
SMALA_5360  methylmalonyl-CoA mutase, large subunit [KO:K01848] [EC:5.4.99.2]
SMALA_3294  methylmalonyl-CoA mutase, large subunit [KO:K01848] [EC:5.4.99.2]
SMALA_1326  methylmalonyl-CoA mutase, large subunit [KO:K01848] [EC:5.4.99.2]
SMALA_2386  6-phosphogluconate dehydrogenase, NAD-binding [KO:K00020] [EC:1.1.1.31]
SMALA_7626  3-hydroxyisobutyrate dehydrogenase [KO:K00020] [EC:1.1.1.31]
SMALA_2742  methylmalonate-semialdehyde dehydrogenase (acylating) [KO:K00140] [EC:1.2.1.18 1.2.1.27]
SMALA_3246  betaine-aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SMALA_7669  piperideine-6-carboxylate dehydrogenase [KO:K00128] [EC:1.2.1.3]
SMALA_3599  putative aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SMALA_2264  aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SMALA_7883  betaine-aldehyde dehydrogenase [KO:K00128] [EC:1.2.1.3]
SMALA_5606  4-aminobutyrate aminotransferase, PLP-dependent [KO:K07250] [EC:2.6.1.19 2.6.1.22 2.6.1.48]
SMALA_2807  propionyl-CoA carboxylase, beta subunit [KO:K01969] [EC:6.4.1.4]
SMALA_2809  hydroxymethylglutaryl-CoA lyase [KO:K01640] [EC:4.1.3.4]
SMALA_0830  hypothetical protein [KO:K01640] [EC:4.1.3.4]
SMALA_0669  acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SMALA_8232  acetoacetyl-CoA synthetase [KO:K01907] [EC:6.2.1.16]
SMALA_5345  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SMALA_0719  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SMALA_3193  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SMALA_2274  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
SMALA_6309  acetyl CoA acetyltransferase (thiolase) [KO:K00626] [EC:2.3.1.9]
SMALA_7151  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00024  Acetyl-CoA
C00068  Thiamin diphosphate
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00164  Acetoacetate
C00183  L-Valine
C00233  4-Methyl-2-oxopentanoate
C00332  Acetoacetyl-CoA
C00349  2-Methyl-3-oxopropanoate
C00356  (S)-3-Hydroxy-3-methylglutaryl-CoA
C00407  L-Isoleucine
C00630  2-Methylpropanoyl-CoA
C00671  (S)-3-Methyl-2-oxopentanoic acid
C00683  (S)-Methylmalonyl-CoA
C01205  (R)-3-Amino-2-methylpropanoate
C01213  (R)-Methylmalonyl-CoA
C02170  Methylmalonate
C02939  3-Methylbutanoyl-CoA
C03069  3-Methylcrotonyl-CoA
C03231  3-Methylglutaconyl-CoA
C03284  L-3-Aminoisobutanoate
C03344  2-Methylacetoacetyl-CoA
C03345  2-Methylbut-2-enoyl-CoA
C03460  2-Methylprop-2-enoyl-CoA
C04405  (2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA
C05996  Branched chain fatty acid
C05998  3-Hydroxyisovaleryl-CoA
C06000  (S)-3-Hydroxyisobutyryl-CoA
C06001  (S)-3-Hydroxyisobutyrate
C06002  (S)-Methylmalonate semialdehyde
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C15974  3-Methyl-1-hydroxybutyl-ThPP
C15975  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine
C15976  2-Methyl-1-hydroxypropyl-ThPP
C15977  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine
C15978  2-Methyl-1-hydroxybutyl-ThPP
C15979  [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine
C15980  (S)-2-Methylbutanoyl-CoA
C20827  3-Hydroxyisovalerate
Related
pathway
smal00020  Citrate cycle (TCA cycle)
smal00240  Pyrimidine metabolism
smal00290  Valine, leucine and isoleucine biosynthesis
smal00640  Propanoate metabolism
smal00900  Terpenoid backbone biosynthesis
KO pathway
ko00280   

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