ID AASD1_DANRE Reviewed; 412 AA.
AC Q6DEJ5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=Alanyl-tRNA editing protein Aarsd1;
DE AltName: Full=Alanyl-tRNA synthetase domain-containing protein 1;
GN Name=aarsd1; ORFNames=zgc:101066;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in trans to edit the amino acid moiety from
CC incorrectly charged tRNA(Ala). {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000305};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC Alax-L subfamily. {ECO:0000305}.
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DR EMBL; BC077118; AAH77118.1; -; mRNA.
DR RefSeq; NP_001003572.1; NM_001003572.1.
DR AlphaFoldDB; Q6DEJ5; -.
DR SMR; Q6DEJ5; -.
DR STRING; 7955.ENSDARP00000011878; -.
DR PaxDb; 7955-ENSDARP00000011878; -.
DR GeneID; 445178; -.
DR KEGG; dre:445178; -.
DR AGR; ZFIN:ZDB-GENE-040801-91; -.
DR CTD; 80755; -.
DR ZFIN; ZDB-GENE-040801-91; aarsd1.
DR eggNOG; KOG2105; Eukaryota.
DR InParanoid; Q6DEJ5; -.
DR OrthoDB; 5490212at2759; -.
DR PhylomeDB; Q6DEJ5; -.
DR PRO; PR:Q6DEJ5; -.
DR Proteomes; UP000000437; Chromosome 12.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004812; F:aminoacyl-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002196; F:Ser-tRNA(Ala) hydrolase activity; IBA:GO_Central.
DR GO; GO:0006450; P:regulation of translational fidelity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR GO; GO:0043039; P:tRNA aminoacylation; IEA:InterPro.
DR Gene3D; 2.40.30.130; -; 1.
DR InterPro; IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR012947; tRNA_SAD.
DR PANTHER; PTHR43462; ALANYL-TRNA EDITING PROTEIN; 1.
DR PANTHER; PTHR43462:SF1; ALANYL-TRNA EDITING PROTEIN AARSD1; 1.
DR Pfam; PF07973; tRNA_SAD; 1.
DR SMART; SM00863; tRNA_SAD; 1.
DR SUPFAM; SSF55186; ThrRS/AlaRS common domain; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Metal-binding; Protein biosynthesis; Reference proteome; Zinc.
FT CHAIN 1..412
FT /note="Alanyl-tRNA editing protein Aarsd1"
FT /id="PRO_0000277468"
FT BINDING 108
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255"
FT BINDING 112
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255"
FT BINDING 208
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255"
FT BINDING 212
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255"
SQ SEQUENCE 412 AA; 45517 MW; 4321F90E712F3200 CRC64;
MAFQCQRDCY MQEFDSCVVS CVPAELKLEN NGRKEKLTGF NVKLKDTILF PEGGGQPDDH
GTIGGVPVLR VLRQGPDAVH FVSSALEEGQ EVHIKLDWER RFDHMQQHSG QHLITALADT
MFGYKTTSWD LGRQRSSIEL DTATVKPGEM EALETAVNEK IRAHVPVTVN LLSIDDPAVE
KVRSRGLPDD HAGPIRIIDI EGVDANMCCG THVSNLSHLQ VIKILGTEKG KKNKTNLIFI
AGNRVLKYAE KSYNIEKSLT VLLKTGADEH VDAVDKLQKT VKRLQKSNLT ILREMAVLIA
QNFKSKPDRG HFFSLHNKDG DNEFMNIVAN EIGFQDTLIF MTVGDEKGAG LFLIAGPENI
VTEVGPRVSE LLQGKGAGKA GRYQGKANSL VKRAEVEALL KERSYKCTAG DE
//
