ID ALR2_RHIL3 Reviewed; 377 AA.
AC Q9RAE7; Q1M447;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 3.
DT 16-JAN-2019, entry version 111.
DE RecName: Full=Alanine racemase, catabolic;
DE EC=5.1.1.1;
GN Name=dadX; OrderedLocusNames=pRL120416;
OS Rhizobium leguminosarum bv. viciae (strain 3841).
OG Plasmid pRL12.
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium.
OX NCBI_TaxID=216596;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10792736; DOI=10.1046/j.1365-2958.2000.01884.x;
RA Allaway D.A., Lodwig E.M., Crompton L.A., Wood M., Parsons R.,
RA Wheeler T.R., Poole P.S.;
RT "Identification of alanine dehydrogenase and its role in mixed
RT secretion of ammonium and alanine by pea bacteroids.";
RL Mol. Microbiol. 36:508-515(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3841; PLASMID=pRL12;
RX PubMed=16640791; DOI=10.1186/gb-2006-7-4-r34;
RA Young J.P.W., Crossman L.C., Johnston A.W.B., Thomson N.R.,
RA Ghazoui Z.F., Hull K.H., Wexler M., Curson A.R.J., Todd J.D.,
RA Poole P.S., Mauchline T.H., East A.K., Quail M.A., Churcher C.,
RA Arrowsmith C., Cherevach I., Chillingworth T., Clarke K., Cronin A.,
RA Davis P., Fraser A., Hance Z., Hauser H., Jagels K., Moule S.,
RA Mungall K., Norbertczak H., Rabbinowitsch E., Sanders M., Simmonds M.,
RA Whitehead S., Parkhill J.;
RT "The genome of Rhizobium leguminosarum has recognizable core and
RT accessory components.";
RL Genome Biol. 7:R34.1-R34.20(2006).
CC -!- FUNCTION: Isomerizes L-alanine to D-alanine which is then oxidized
CC to pyruvate by DadA.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249,
CC ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1;
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the alanine racemase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB53547.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR EMBL; AJ249196; CAB53547.1; ALT_INIT; Genomic_DNA.
DR EMBL; AM236086; CAK12125.1; -; Genomic_DNA.
DR RefSeq; WP_011649181.1; NC_008378.1.
DR ProteinModelPortal; Q9RAE7; -.
DR SMR; Q9RAE7; -.
DR EnsemblBacteria; CAK12125; CAK12125; pRL120416.
DR KEGG; rle:pRL120416; -.
DR HOGENOM; HOG000031445; -.
DR KO; K01775; -.
DR OMA; VEILFIM; -.
DR OrthoDB; 859043at2; -.
DR Proteomes; UP000006575; Plasmid pRL12.
DR GO; GO:0008784; F:alanine racemase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006522; P:alanine metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.37.10; -; 1.
DR Gene3D; 3.20.20.10; -; 1.
DR HAMAP; MF_01201; Ala_racemase; 1.
DR InterPro; IPR000821; Ala_racemase.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR011079; Ala_racemase_C.
DR InterPro; IPR001608; Ala_racemase_N.
DR InterPro; IPR020622; Ala_racemase_pyridoxalP-BS.
DR InterPro; IPR029066; PLP-binding_barrel.
DR Pfam; PF00842; Ala_racemase_C; 1.
DR Pfam; PF01168; Ala_racemase_N; 1.
DR PRINTS; PR00992; ALARACEMASE.
DR SMART; SM01005; Ala_racemase_C; 1.
DR SUPFAM; SSF50621; SSF50621; 1.
DR SUPFAM; SSF51419; SSF51419; 1.
DR TIGRFAMs; TIGR00492; alr; 1.
DR PROSITE; PS00395; ALANINE_RACEMASE; 1.
PE 3: Inferred from homology;
KW Complete proteome; Isomerase; Plasmid; Pyridoxal phosphate.
FT CHAIN 1 377 Alanine racemase, catabolic.
FT /FTId=PRO_0000114554.
FT ACT_SITE 51 51 Proton acceptor; specific for D-alanine.
FT {ECO:0000250}.
FT ACT_SITE 272 272 Proton acceptor; specific for L-alanine.
FT {ECO:0000250}.
FT BINDING 150 150 Substrate. {ECO:0000250}.
FT BINDING 320 320 Substrate; via amide nitrogen.
FT {ECO:0000250}.
FT MOD_RES 51 51 N6-(pyridoxal phosphate)lysine.
FT {ECO:0000250}.
SQ SEQUENCE 377 AA; 40548 MW; BB38DAC35BD3DBF2 CRC64;
MDSDILVSRT RTATIAQGAT GYLMIDLAAL GRNYRKLVSM LAPVRAGAVV KADAYGLGAE
RVARTLYSEG CRHFFVAQFV EAVRLRPALA HDAQIFVLNG LQPGNEIACA EMGIVPVLNS
LAQWRQWSAA ARILKRCLPA VLQFDTGMSR LGFPREERRE LAAALRDGSN VEILFIMSHL
ASADDMGSEQ NGEQFAEMSR IADEFPGFDI SFANSGGVFL GEAYYGVLAR PGIALYGGAP
NAGEKNPMEP VVSLNVAVVQ TRTVPAGAKV GYGGAHVTQR ETRLATIAAG YADGLPRCLS
DRGAVYFKGV RLPIVGRVSM DSTTVDITAL PEGALTFGSL VEVLGRHQTL EDIARDAGTI
SYEILTGLGD RYDRQYR
//