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Database: UniProt/SWISS-PROT
Entry: AOR_THEKO
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ID   AOR_THEKO               Reviewed;         605 AA.
AC   Q5JE15;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   07-NOV-2018, entry version 84.
DE   RecName: Full=Tungsten-containing aldehyde ferredoxin oxidoreductase;
DE            EC=1.2.7.5;
GN   Name=aor; OrderedLocusNames=TK1066;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon
RT   Thermococcus kodakaraensis KOD1 and comparison with Pyrococcus
RT   genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + H(2)O + 2 oxidized ferredoxin =
CC       a carboxylate + 2 H(+) + 2 reduced ferredoxin.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=W-bis(molybdopterin guanine dinucleotide);
CC         Xref=ChEBI:CHEBI:60537; Evidence={ECO:0000250};
CC       Note=Binds 1 W-bis(molybdopterin guanine dinucleotide) (W-bis-MGD)
CC       cofactor per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AOR/FOR family. {ECO:0000305}.
DR   EMBL; AP006878; BAD85255.1; -; Genomic_DNA.
DR   RefSeq; WP_011250017.1; NC_006624.1.
DR   ProteinModelPortal; Q5JE15; -.
DR   SMR; Q5JE15; -.
DR   STRING; 69014.TK1066; -.
DR   EnsemblBacteria; BAD85255; BAD85255; TK1066.
DR   GeneID; 3233851; -.
DR   KEGG; tko:TK1066; -.
DR   PATRIC; fig|69014.16.peg.1042; -.
DR   eggNOG; arCOG00706; Archaea.
DR   eggNOG; COG2414; LUCA.
DR   HOGENOM; HOG000014651; -.
DR   InParanoid; Q5JE15; -.
DR   KO; K03738; -.
DR   OMA; YFMGVKK; -.
DR   OrthoDB; POG093Z03Y8; -.
DR   BioCyc; TKOD69014:G1G2A-1055-MONOMER; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0033726; F:aldehyde ferredoxin oxidoreductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.569.10; -; 1.
DR   Gene3D; 1.10.599.10; -; 1.
DR   Gene3D; 3.60.9.10; -; 1.
DR   InterPro; IPR013984; Ald_Fedxn_OxRdtase_dom2.
DR   InterPro; IPR013985; Ald_Fedxn_OxRdtase_dom3.
DR   InterPro; IPR013983; Ald_Fedxn_OxRdtase_N.
DR   InterPro; IPR036503; Ald_Fedxn_OxRdtase_N_sf.
DR   InterPro; IPR001203; OxRdtase_Ald_Fedxn_C.
DR   InterPro; IPR036021; Tungsten_al_ferr_oxy-like_C.
DR   Pfam; PF01314; AFOR_C; 1.
DR   Pfam; PF02730; AFOR_N; 1.
DR   SMART; SM00790; AFOR_N; 1.
DR   SUPFAM; SSF48310; SSF48310; 1.
DR   SUPFAM; SSF56228; SSF56228; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Reference proteome; Tungsten.
FT   CHAIN         1    605       Tungsten-containing aldehyde ferredoxin
FT                                oxidoreductase.
FT                                /FTId=PRO_0000064608.
SQ   SEQUENCE   605 AA;  66768 MW;  CCDA95873B3AC062 CRC64;
     MYGNWGRFLR VNLSTGEVKV EEYGEELAKK WLGSRGLAIY LLLKEMDPKA DPLGPENKLI
     ITPGPLTGTS APTGGRYNVV TKSPQTGFIT MANSGGYFGA ELKFAGWDAI VVEGQSEKPV
     YIYIKDDHVE IRDASHLWGK VVSETEAAIK KEIGSNKLHI ASIGPAGENL VKFAAIMNDG
     HRAAGRAGVG AVMGSKKLKA IAVEGSKRVP IADKQKFMLV VREKINKLRN DPVAGGGLPK
     YGTAVLVNII NENGLYPTRN FQTGVFEHAY EQSGEAMTAK YLIRNQPCYA CPIGCGRVNK
     LPTLGVTEGP EYESIWALGA NLGINDLASI IEANHQCDEF GLDTISTGGT LAAAMELYEK
     GYLTDDELGD APPFRWGNTE VLHYYIEKIA YRKDLGDKLA EGSYRFAEMY GHPEFSMSVK
     KLELPAYDPR GAEGHGLGYA TNNRGGCHIK NYMISPEILG YPYKMDPHDI SDEKVKMLIL
     FQDLSALIDA AGLCLFTTFG LGADDYRDML NAALGWDFST EDYLKIGERI WNAERLFNLK
     AGLDPAKDET LPKRFLEEPM PEGPNKGHVV RLKEMLPRYY KLRGWTEDGR IPREKAEELG
     IAEFL
//
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