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Database: UniProt/SWISS-PROT
Entry: B3GT1_GORGO
LinkDB: B3GT1_GORGO
Original site: B3GT1_GORGO 
ID   B3GT1_GORGO             Reviewed;         326 AA.
AC   Q7JK24;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   05-DEC-2018, entry version 82.
DE   RecName: Full=Beta-1,3-galactosyltransferase 1;
DE            Short=Beta-1,3-GalTase 1;
DE            Short=Beta3Gal-T1;
DE            Short=Beta3GalT1;
DE            EC=2.4.1.86 {ECO:0000250|UniProtKB:Q9Y5Z6};
DE   AltName: Full=UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1;
GN   Name=B3GALT1;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15014171; DOI=10.1093/molbev/msh100;
RA   Kitano T., Liu Y.-H., Ueda S., Saitou N.;
RT   "Human-specific amino acid changes found in 103 protein-coding
RT   genes.";
RL   Mol. Biol. Evol. 21:936-944(2004).
CC   -!- FUNCTION: Beta-1,3-galactosyltransferase that transfers galactose
CC       from UDP-galactose to substrates with a terminal beta-N-
CC       acetylglucosamine (beta-GlcNAc) residue. Involved in the
CC       biosynthesis of the carbohydrate moieties of glycolipids and
CC       glycoproteins. {ECO:0000250|UniProtKB:Q9Y5Z6}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-
CC         galactose = a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-
CC         glucosaminyl derivative + H(+) + UDP; Xref=Rhea:RHEA:53432,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:61631,
CC         ChEBI:CHEBI:66914, ChEBI:CHEBI:133506; EC=2.4.1.86;
CC         Evidence={ECO:0000250|UniProtKB:Q9Y5Z6};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305};
CC       Single-pass type II membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 31 family.
CC       {ECO:0000305}.
DR   EMBL; AB041410; BAA94495.1; -; Genomic_DNA.
DR   RefSeq; XP_004032783.1; XM_004032735.2.
DR   ProteinModelPortal; Q7JK24; -.
DR   SMR; Q7JK24; -.
DR   STRING; 9593.ENSGGOP00000007931; -.
DR   Ensembl; ENSGGOT00000008148; ENSGGOP00000007931; ENSGGOG00000008115.
DR   GeneID; 101153312; -.
DR   KEGG; ggo:101153312; -.
DR   CTD; 8708; -.
DR   GeneTree; ENSGT00940000156219; -.
DR   HOVERGEN; HBG101354; -.
DR   InParanoid; Q7JK24; -.
DR   KO; K07819; -.
DR   OMA; HPYQNSG; -.
DR   OrthoDB; EOG091G0AXM; -.
DR   UniPathway; UPA00378; -.
DR   Proteomes; UP000001519; Unplaced.
DR   Bgee; ENSGGOG00000008115; Expressed in 3 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008376; F:acetylgalactosaminyltransferase activity; IBA:GO_Central.
DR   GO; GO:0047275; F:glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008499; F:UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006682; P:galactosylceramide biosynthetic process; IEA:Ensembl.
DR   GO; GO:0030259; P:lipid glycosylation; IEA:Ensembl.
DR   GO; GO:0009312; P:oligosaccharide biosynthetic process; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   GO; GO:0006487; P:protein N-linked glycosylation; IBA:GO_Central.
DR   InterPro; IPR002659; Glyco_trans_31.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR11214; PTHR11214; 1.
DR   Pfam; PF01762; Galactosyl_T; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Glycosyltransferase; Golgi apparatus;
KW   Manganese; Membrane; Reference proteome; Signal-anchor; Transferase;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    326       Beta-1,3-galactosyltransferase 1.
FT                                /FTId=PRO_0000219144.
FT   TOPO_DOM      1      6       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM      7     26       Helical; Signal-anchor for type II
FT                                membrane protein. {ECO:0000255}.
FT   TOPO_DOM     27    326       Lumenal. {ECO:0000255}.
FT   CARBOHYD     47     47       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    151    151       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   326 AA;  37993 MW;  83271E99B2EE74F5 CRC64;
     MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF GNIRTRPINP
     HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET WGDENNFKGI KIATLFLLGK
     NADPVLNQMV EQESQIFHDI IVEDFIDSYH NLTLKTLMGM RWVATFCSKA KYVMKTDSDI
     FVNMDNLIYK LLKPSTKPRR RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG
     YIFSADVAEL IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV
     ITVHQISPEE MHRIWNDMSS KKHLRC
//
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