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Database: UniProt/SWISS-PROT
Entry: CAPPA_METS5
LinkDB: CAPPA_METS5
Original site: CAPPA_METS5 
ID   CAPPA_METS5             Reviewed;         509 AA.
AC   A4YES9;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   10-OCT-2018, entry version 62.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000255|HAMAP-Rule:MF_01904};
DE            Short=PEPC {ECO:0000255|HAMAP-Rule:MF_01904};
DE            Short=PEPCase {ECO:0000255|HAMAP-Rule:MF_01904};
DE            EC=4.1.1.31 {ECO:0000255|HAMAP-Rule:MF_01904};
GN   Name=ppcA {ECO:0000255|HAMAP-Rule:MF_01904};
GN   OrderedLocusNames=Msed_0756;
OS   Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC
OS   15509 / TH2).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Metallosphaera.
OX   NCBI_TaxID=399549;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2;
RX   PubMed=18083856; DOI=10.1128/AEM.02019-07;
RA   Auernik K.S., Maezato Y., Blum P.H., Kelly R.M.;
RT   "The genome sequence of the metal-mobilizing, extremely
RT   thermoacidophilic archaeon Metallosphaera sedula provides insights
RT   into bioleaching-associated metabolism.";
RL   Appl. Environ. Microbiol. 74:682-692(2008).
CC   -!- FUNCTION: Catalyzes the irreversible beta-carboxylation of
CC       phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-
CC       carbon dicarboxylic acid source for the tricarboxylic acid cycle.
CC       {ECO:0000255|HAMAP-Rule:MF_01904}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000255|HAMAP-
CC       Rule:MF_01904}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01904};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_01904}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 2 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01904}.
DR   EMBL; CP000682; ABP94931.1; -; Genomic_DNA.
DR   RefSeq; WP_012020718.1; NC_009440.1.
DR   SMR; A4YES9; -.
DR   STRING; 399549.Msed_0756; -.
DR   PRIDE; A4YES9; -.
DR   EnsemblBacteria; ABP94931; ABP94931; Msed_0756.
DR   GeneID; 5103445; -.
DR   KEGG; mse:Msed_0756; -.
DR   eggNOG; arCOG04435; Archaea.
DR   eggNOG; COG1892; LUCA.
DR   HOGENOM; HOG000038601; -.
DR   KO; K01595; -.
DR   OMA; PAMNYGL; -.
DR   OrthoDB; POG093Z01LI; -.
DR   Proteomes; UP000000242; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_01904; PEPcase_type2; 1.
DR   InterPro; IPR007566; PEP_COase_arc-type.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   Pfam; PF14010; PEPcase_2; 1.
DR   PIRSF; PIRSF006677; UCP006677; 1.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   TIGRFAMs; TIGR02751; PEPCase_arch; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation; Complete proteome; Lyase; Magnesium;
KW   Reference proteome.
FT   CHAIN         1    509       Phosphoenolpyruvate carboxylase.
FT                                /FTId=PRO_1000088478.
SQ   SEQUENCE   509 AA;  58245 MW;  FCF967A96862D3C5 CRC64;
     MRPIPRTMST QHPDNATVPE WAKGDVIEGE AEVIEAYYAF SRLNVHEVMW DAEGKDVDTH
     VVRKLFSSFD EYFKNNILGE DIFLTYRLPN PKIEGAERKV FAETMESIPI TFDVAERFYG
     RKVVPVFEVI LPFTTNASDI ISVARYYERA VAMEENIELQ DGVYVRDLVG EIYPKRIEVI
     PLIEDKDSLL NTRNIIEGYY RAIKPSYMRL FIARSDPAMN YGMLTAVLLA KYALSEAGKL
     AEELGIPIFP IIGVGSLPFR GHLSPENYQR VMEEYEGVYT FTIQSAFKYD YSEEQVKGAI
     SHINREEVKE PRILGEEEKK VTRDIIETYT LSYQPVIESL ANLINTVALH LPRRRARKLH
     ISLFGYARST GKVMLPRAIT FVGSLYSVGL PPEVIGISSL GKLNEMQWNI LEENYKFLKN
     DLQKASEFIN PEGLSTLVSY GYLDAEISKK LEEDIKYLES MGVKIGPRSY ETKKHALLSQ
     LLMLSLKEKK YNEVKQYARE MAVIRKSIG
//
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