ID CCG3_BOVIN Reviewed; 315 AA.
AC Q0VD05;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 24-JAN-2024, entry version 104.
DE RecName: Full=Voltage-dependent calcium channel gamma-3 subunit;
DE AltName: Full=Neuronal voltage-gated calcium channel gamma-3 subunit;
DE AltName: Full=Transmembrane AMPAR regulatory protein gamma-3;
DE Short=TARP gamma-3;
GN Name=CACNG3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Brain cortex;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulates the trafficking and gating properties of AMPA-
CC selective glutamate receptors (AMPARs). Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC slowing their rates of activation, deactivation and desensitization.
CC Does not show subunit-specific AMPA receptor regulation and regulates
CC all AMPAR subunits. Thought to stabilize the calcium channel in an
CC inactivated (closed) state. {ECO:0000250|UniProtKB:Q8VHX0}.
CC -!- SUBUNIT: The L-type calcium channel is composed of five subunits:
CC alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit
CC for AMPA-selective glutamate receptors (AMPARs). Found in a complex
CC with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5,
CC CACNG7 and CACNG8. Interacts with AP4M1 and GRIA1; associates GRIA1
CC with the adaptor protein complex 4 (AP-4) to target GRIA1 to the
CC somatodendritic compartment of neurons. {ECO:0000250|UniProtKB:Q8VHX0,
CC ECO:0000250|UniProtKB:Q9JJV5}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}. Note=Displays a somatodendritic localization and
CC is excluded from axons in neurons. {ECO:0000250|UniProtKB:Q9JJV5}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000305}.
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DR EMBL; BC119905; AAI19906.1; -; mRNA.
DR RefSeq; NP_001071482.1; NM_001078014.1.
DR AlphaFoldDB; Q0VD05; -.
DR SMR; Q0VD05; -.
DR STRING; 9913.ENSBTAP00000001841; -.
DR PaxDb; 9913-ENSBTAP00000001841; -.
DR Ensembl; ENSBTAT00000001841.5; ENSBTAP00000001841.4; ENSBTAG00000001404.5.
DR GeneID; 538496; -.
DR KEGG; bta:538496; -.
DR CTD; 10368; -.
DR VEuPathDB; HostDB:ENSBTAG00000001404; -.
DR VGNC; VGNC:26688; CACNG3.
DR eggNOG; ENOG502QVF5; Eukaryota.
DR GeneTree; ENSGT01050000244893; -.
DR HOGENOM; CLU_053704_0_1_1; -.
DR InParanoid; Q0VD05; -.
DR OMA; QIHNSIP; -.
DR OrthoDB; 2957055at2759; -.
DR TreeFam; TF327980; -.
DR Reactome; R-BTA-399719; Trafficking of AMPA receptors.
DR Reactome; R-BTA-5682910; LGI-ADAM interactions.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000001404; Expressed in occipital lobe and 13 other cell types or tissues.
DR GO; GO:0032281; C:AMPA glutamate receptor complex; ISS:UniProtKB.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0098839; C:postsynaptic density membrane; IBA:GO_Central.
DR GO; GO:0098685; C:Schaffer collateral - CA1 synapse; IEA:Ensembl.
DR GO; GO:0036477; C:somatodendritic compartment; ISS:UniProtKB.
DR GO; GO:0016247; F:channel regulator activity; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0099590; P:neurotransmitter receptor internalization; IBA:GO_Central.
DR GO; GO:0099645; P:neurotransmitter receptor localization to postsynaptic specialization membrane; IEA:Ensembl.
DR GO; GO:0098943; P:neurotransmitter receptor transport, postsynaptic endosome to lysosome; IBA:GO_Central.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR GO; GO:0098970; P:postsynaptic neurotransmitter receptor diffusion trapping; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0006605; P:protein targeting; ISS:UniProtKB.
DR GO; GO:2000311; P:regulation of AMPA receptor activity; ISS:UniProtKB.
DR GO; GO:0019226; P:transmission of nerve impulse; IBA:GO_Central.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF5; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNIT; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
PE 2: Evidence at transcript level;
KW Calcium; Calcium channel; Calcium transport; Ion channel; Ion transport;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Voltage-gated channel.
FT CHAIN 1..315
FT /note="Voltage-dependent calcium channel gamma-3 subunit"
FT /id="PRO_0000273425"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 232..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 248
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8VHX0"
SQ SEQUENCE 315 AA; 35500 MW; 01D594E15348FFA0 CRC64;
MRMCDRGVQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH
SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL
CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY
FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSELLKKST FARLPPYRYR FRRRSSSRST
EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
ESLHNNPANR RTTPV
//
