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Database: UniProt/SWISS-PROT
Entry: CSAD_MOUSE
LinkDB: CSAD_MOUSE
Original site: CSAD_MOUSE 
ID   CSAD_MOUSE              Reviewed;         493 AA.
AC   Q9DBE0; Q8K566;
DT   13-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   20-JUN-2018, entry version 124.
DE   RecName: Full=Cysteine sulfinic acid decarboxylase;
DE            EC=4.1.1.29;
DE   AltName: Full=Cysteine-sulfinate decarboxylase;
DE   AltName: Full=Sulfinoalanine decarboxylase;
GN   Name=Csad;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=11997111; DOI=10.1016/S0167-4781(01)00364-5;
RA   Park E., Park S.Y., Wang C., Xu J., LaFauci G., Schuller-Levis G.;
RT   "Cloning of murine cysteine sulfinic acid decarboxylase and its mRNA
RT   expression in murine tissues.";
RL   Biochim. Biophys. Acta 1574:403-406(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Liver;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Kidney, Liver, Lung, Pancreas, and
RC   Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- CATALYTIC ACTIVITY: 3-sulfino-L-alanine = hypotaurine + CO(2).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Organosulfur biosynthesis; taurine biosynthesis;
CC       hypotaurine from L-cysteine: step 2/2.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in kidney and liver not detected in
CC       lymphoid tissues and lung. {ECO:0000269|PubMed:11997111}.
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000305}.
DR   EMBL; AY033912; AAK60398.1; -; mRNA.
DR   EMBL; AK005015; BAB23747.1; -; mRNA.
DR   CCDS; CCDS27873.1; -.
DR   RefSeq; NP_659191.1; NM_144942.4.
DR   RefSeq; XP_006521062.1; XM_006520999.3.
DR   UniGene; Mm.296382; -.
DR   ProteinModelPortal; Q9DBE0; -.
DR   SMR; Q9DBE0; -.
DR   IntAct; Q9DBE0; 2.
DR   MINT; Q9DBE0; -.
DR   STRING; 10090.ENSMUSP00000023805; -.
DR   iPTMnet; Q9DBE0; -.
DR   PhosphoSitePlus; Q9DBE0; -.
DR   SwissPalm; Q9DBE0; -.
DR   MaxQB; Q9DBE0; -.
DR   PaxDb; Q9DBE0; -.
DR   PeptideAtlas; Q9DBE0; -.
DR   PRIDE; Q9DBE0; -.
DR   DNASU; 246277; -.
DR   Ensembl; ENSMUST00000023805; ENSMUSP00000023805; ENSMUSG00000023044.
DR   GeneID; 246277; -.
DR   KEGG; mmu:246277; -.
DR   UCSC; uc007xuu.1; mouse.
DR   CTD; 51380; -.
DR   MGI; MGI:2180098; Csad.
DR   eggNOG; KOG0629; Eukaryota.
DR   eggNOG; COG0076; LUCA.
DR   GeneTree; ENSGT00760000119205; -.
DR   HOGENOM; HOG000005382; -.
DR   HOVERGEN; HBG004980; -.
DR   InParanoid; Q9DBE0; -.
DR   KO; K01594; -.
DR   OMA; SQYTYEI; -.
DR   OrthoDB; EOG091G07ZU; -.
DR   PhylomeDB; Q9DBE0; -.
DR   TreeFam; TF314688; -.
DR   BRENDA; 4.1.1.29; 3474.
DR   UniPathway; UPA00012; UER00538.
DR   PRO; PR:Q9DBE0; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000023044; -.
DR   CleanEx; MM_CSAD; -.
DR   Genevisible; Q9DBE0; MM.
DR   GO; GO:0016831; F:carboxy-lyase activity; TAS:MGI.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0004782; F:sulfinoalanine decarboxylase activity; ISO:MGI.
DR   GO; GO:0019452; P:L-cysteine catabolic process to taurine; TAS:MGI.
DR   GO; GO:0042412; P:taurine biosynthetic process; IMP:MGI.
DR   GO; GO:0019530; P:taurine metabolic process; TAS:MGI.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR021115; Pyridoxal-P_BS.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   PROSITE; PS00392; DDC_GAD_HDC_YDC; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Decarboxylase; Lyase; Pyridoxal phosphate;
KW   Reference proteome.
FT   CHAIN         1    493       Cysteine sulfinic acid decarboxylase.
FT                                /FTId=PRO_0000147007.
FT   MOD_RES     305    305       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000250}.
FT   CONFLICT    160    160       M -> I (in Ref. 1; AAK60398).
FT                                {ECO:0000305}.
SQ   SEQUENCE   493 AA;  55145 MW;  BA92298DA0086A02 CRC64;
     MADSKPLRTL DGDPVAVEAL LQDVFGIVVD EAILKGTSAS EKVCEWKEPE ELKQLLDLEL
     QSQGESREQI LERCRTVIHY SVKTGHPRFF NQLFSGLDPH ALAGRIITES LNTSQYTYEI
     APVFVLMEEE VLKKLRALVG WNSGDGVFCP GGSISNMYAM NLARFQRYPD CKQRGLRALP
     PLALFTSKEC HYSITKGAAF LGLGTDSVRV VKADERGRMI PEDLERQIIL AEAEGSVPFL
     VSATSGTTVL GAFDPLDAIA DVCQRHGLWF HVDAAWGGSV LLSRTHRHLL DGIQRADSVA
     WNPHKLLAAG LQCSALLLRD TSNLLKRCHG SQASYLFQQD KFYDVALDTG DKVVQCGRRV
     DCLKLWLMWK AQGGQGLERR IDQAFALTRY LVEEIKKREG FELVMEPEFV NVCFWFVPPS
     LRGKKESPDY SQRLSQVAPV LKERMVKKGT MMIGYQPHGT RANFFRMVVA NPILAQADID
     FLLGELELLG QDL
//
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