ID CXCR1_MACMU Reviewed; 351 AA.
AC Q2YEG0;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=C-X-C chemokine receptor type 1;
DE Short=CXC-R1;
DE Short=CXCR-1;
DE AltName: Full=High affinity interleukin-8 receptor A;
DE Short=IL-8R A;
DE AltName: Full=IL-8 receptor type 1;
DE AltName: CD_antigen=CD181;
GN Name=CXCR1; Synonyms=IL8RA;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=16205979; DOI=10.1007/s00239-005-0039-x;
RA Liu Y., Yang S., Lin A.A., Cavalli-Sforza L.L., Su B.;
RT "Molecular evolution of CXCR1, a G protein-coupled receptor involved in
RT signal transduction of neutrophils.";
RL J. Mol. Evol. 61:691-696(2005).
CC -!- FUNCTION: Receptor to interleukin-8, which is a powerful neutrophils
CC chemotactic factor. Binding of IL-8 to the receptor causes activation
CC of neutrophils. This response is mediated via a G-protein that
CC activates a phosphatidylinositol-calcium second messenger system.
CC {ECO:0000250|UniProtKB:P25024}.
CC -!- SUBUNIT: Interacts with IL8. Interacts with GNAI2.
CC {ECO:0000250|UniProtKB:P25024}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY916770; AAY21520.1; -; Genomic_DNA.
DR RefSeq; NP_001035510.1; NM_001040420.1.
DR RefSeq; XP_014966445.1; XM_015110959.1.
DR RefSeq; XP_014966446.1; XM_015110960.1.
DR RefSeq; XP_014966447.1; XM_015110961.1.
DR RefSeq; XP_014966448.1; XM_015110962.1.
DR AlphaFoldDB; Q2YEG0; -.
DR SMR; Q2YEG0; -.
DR STRING; 9544.ENSMMUP00000065767; -.
DR GlyCosmos; Q2YEG0; 4 sites, No reported glycans.
DR PaxDb; 9544-ENSMMUP00000025429; -.
DR Ensembl; ENSMMUT00000027182.4; ENSMMUP00000025429.2; ENSMMUG00000019351.4.
DR Ensembl; ENSMMUT00000098782.1; ENSMMUP00000065767.1; ENSMMUG00000019351.4.
DR GeneID; 692074; -.
DR KEGG; mcc:692074; -.
DR CTD; 3577; -.
DR VEuPathDB; HostDB:ENSMMUG00000019351; -.
DR VGNC; VGNC:71616; CXCR1.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244848; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR InParanoid; Q2YEG0; -.
DR OMA; SPVCYEV; -.
DR OrthoDB; 5347598at2759; -.
DR TreeFam; TF330966; -.
DR Proteomes; UP000006718; Chromosome 12.
DR Bgee; ENSMMUG00000019351; Expressed in spermatid and 5 other cell types or tissues.
DR ExpressionAtlas; Q2YEG0; baseline.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0019957; F:C-C chemokine binding; IBA:GO_Central.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IBA:GO_Central.
DR GO; GO:0019959; F:interleukin-8 binding; IEA:Ensembl.
DR GO; GO:0004918; F:interleukin-8 receptor activity; IEA:Ensembl.
DR GO; GO:0019722; P:calcium-mediated signaling; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0031623; P:receptor internalization; IEA:Ensembl.
DR CDD; cd15178; 7tmA_CXCR1_2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001355; Chemokine_CXCR1.
DR InterPro; IPR000174; Chemokine_CXCR_1/2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF916; C-X-C CHEMOKINE RECEPTOR TYPE 1; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00427; INTRLEUKIN8R.
DR PRINTS; PR00572; INTRLEUKN8AR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chemotaxis; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..351
FT /note="C-X-C chemokine receptor type 1"
FT /id="PRO_0000237619"
FT TOPO_DOM 1..46
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 3
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 194
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 111..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 351 AA; 39811 MW; 050FDC46423AD4A1 CRC64;
MSNATDPQMG DDDYDLNFTG MPPTDEDYSP CRLETQSLNK YVVIVTYALV FLLSLLGNSL
VMLVILYRRV GRSVTDVYLL NLAMADLLFA LTLPIWAASK VNGWIFGTFL CKVVSLLKEV
NFYSGILLLA CISVDRYLAI VHATRTLIQK RHSVKFVCLS CWGLSVILSL PFFLFRQAYH
PNNSTPVCYE VLGNDTAKWR MVLRILPHTF GFTLPLLIML FCYGFTLHTL FKAHIGQKHR
AMRVIFAVVL IFLLCWLPYN LVLLADTLMR THLIKESCER RNDIGRALDA TEILGFLHSC
LNPIIYAFIG QNFRHGFLKI LATHGLVSKE FLARHHVTSY TSSSVNVSSN L
//