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Database: UniProt/SWISS-PROT
Entry: DNLI4_PHANO
LinkDB: DNLI4_PHANO
Original site: DNLI4_PHANO 
ID   DNLI4_PHANO             Reviewed;         990 AA.
AC   Q0UCI9;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   23-MAY-2018, entry version 81.
DE   RecName: Full=DNA ligase 4;
DE            EC=6.5.1.1;
DE   AltName: Full=DNA ligase IV;
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] 4;
GN   Name=LIG4; ORFNames=SNOG_10525;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
OS   (Glume blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
OC   Phaeosphaeriaceae; Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing
RT   and EST analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
CC   -!- FUNCTION: Involved in ds DNA break repair. Has a role in non-
CC       homologous integration (NHI) pathways where it is required in the
CC       final step of non-homologous end-joining. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000255|PROSITE-ProRule:PRU10135}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000305}.
DR   EMBL; CH445341; EAT81919.1; -; Genomic_DNA.
DR   RefSeq; XP_001800794.1; XM_001800742.1.
DR   ProteinModelPortal; Q0UCI9; -.
DR   SMR; Q0UCI9; -.
DR   STRING; 13684.SNOT_10525; -.
DR   EnsemblFungi; SNOT_10525; SNOT_10525; SNOG_10525.
DR   GeneID; 5977701; -.
DR   KEGG; pno:SNOG_10525; -.
DR   InParanoid; Q0UCI9; -.
DR   KO; K10777; -.
DR   OMA; HMCPSTK; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0032807; C:DNA ligase IV complex; IBA:GO_Central.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IBA:GO_Central.
DR   GO; GO:0006297; P:nucleotide-excision repair, DNA gap filling; IBA:GO_Central.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; DNA damage; DNA recombination;
KW   DNA repair; DNA replication; Ligase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome; Repeat.
FT   CHAIN         1    990       DNA ligase 4.
FT                                /FTId=PRO_0000278385.
FT   DOMAIN      728    821       BRCT 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00033}.
FT   DOMAIN      900    989       BRCT 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00033}.
FT   ACT_SITE    326    326       N6-AMP-lysine intermediate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10135}.
FT   METAL       394    394       Magnesium 1. {ECO:0000255}.
FT   METAL       496    496       Magnesium 2. {ECO:0000255}.
FT   BINDING     324    324       ATP. {ECO:0000250}.
FT   BINDING     331    331       ATP. {ECO:0000250}.
FT   BINDING     353    353       ATP. {ECO:0000250}.
FT   BINDING     501    501       ATP. {ECO:0000250}.
FT   BINDING     512    512       ATP. {ECO:0000250}.
FT   BINDING     518    518       ATP. {ECO:0000250}.
SQ   SEQUENCE   990 AA;  113591 MW;  8B9386A5E66CAA50 CRC64;
     MAEDTEMPDA EAVRENTLMY GHDDELDEKF PTRPMNLHKS PPFHTLFTDL FDPLMETQKK
     GRQPPGPRRK AGPHGHSNLS PHEAKRNIIE RFIASWRKTV GNDFYPAMRL IIPDKDRDRA
     MYGLKEKAIA KVLIKLTKIS KDSDDAKQML NWKLPGQLHK ASASTAGDFA GRCYQVLSSR
     QLNTKLGDMS IAEVNNALDK LSQLGSEDEQ VKIFQRFNRR MNAEEMTWLI RIILRQMKIG
     ATEKTFLDIW HPDAETLFNI SSNLRRVCWE LYDPKVRLEG EDTGLSLMQC FQPQLAAFQD
     KGGSFEKIVA RLQANSDDDS FWIEEKLDGE RMQLHMIEDP EAPGGKLFGF WSRKAKDYAY
     LYGKHLQGDE AGALTRFITD AFGKNVRNII LDGEMITWDM DVDHIVGFGT LKTAAISEKE
     NKTDKSTGQR PLFRVFDCVY LNDKLLTPYT LRDRRRALES AVKDVKRRLE IHPYIEAHSH
     TEIEPALRKV VAESSEGLVL KNPRSMYRLN DRNADWMKVK PEYMSEFGES LDCIVVGGYF
     GSGHRGGAHS SFLCALLLNK DAKPGDADYE KCWSFFKVGG GFSREDYAAI RGRTEGKWKD
     WDPRRPPPII ELGGHEQNRQ HERPDQWIHP SDSVVLECKA ASVEGSDKFR FNLTLRFPRF
     RMLRTDKRWD QALSREEFYE IKANVEYKRE EKEKEFEIEK SRRKRTRTTK KPIVVAGSET
     ITTPYAGPQS KIFDGLSFYI MTEQLHPTKK SKVDLEALVK ANGGRVVQRD SMEPNLVIVA
     DKRLIKVASL EKRDTNNIVK PVWIQDTIQQ NEVDNGALPY LLPFEPNRHM FYLLGDNQLD
     YEANADDYGD SYARDIADVE EMRKILGATD PPQKRTKFDR ESFLDQLEDH GDSLSHLKTY
     MFSSTKVAFR TSDDPVWTLR AQLAGNYIRF GGGQITEDED EEGVTHTVVP DGQTASVSRV
     ADLSRVVGVG WVQKCWDEST RLDEERYQWG
//
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