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Database: UniProt/SWISS-PROT
Entry: DNLI_BEUC1
LinkDB: DNLI_BEUC1
Original site: DNLI_BEUC1 
ID   DNLI_BEUC1              Reviewed;         512 AA.
AC   C5BW79;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   23-MAY-2018, entry version 61.
DE   RecName: Full=Probable DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407};
DE            EC=6.5.1.1 {ECO:0000255|HAMAP-Rule:MF_00407};
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] {ECO:0000255|HAMAP-Rule:MF_00407};
GN   Name=lig {ECO:0000255|HAMAP-Rule:MF_00407};
GN   OrderedLocusNames=Bcav_0272;
OS   Beutenbergia cavernae (strain ATCC BAA-8 / DSM 12333 / NBRC 16432).
OC   Bacteria; Actinobacteria; Micrococcales; Beutenbergiaceae;
OC   Beutenbergia.
OX   NCBI_TaxID=471853;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-8 / DSM 12333 / NBRC 16432;
RX   PubMed=21304633; DOI=10.4056/sigs.1162;
RA   Land M., Pukall R., Abt B., Goker M., Rohde M., Glavina Del Rio T.,
RA   Tice H., Copeland A., Cheng J.F., Lucas S., Chen F., Nolan M.,
RA   Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K.,
RA   Ovchinnikova G., Pati A., Chen A., Palaniappan K., Hauser L.,
RA   Chang Y.J., Jefferies C.C., Saunders E., Brettin T., Detter J.C.,
RA   Han C., Chain P., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA   Kyrpides N.C., Klenk H.P., Lapidus A.;
RT   "Complete genome sequence of Beutenbergia cavernae type strain (HKI
RT   0122).";
RL   Stand. Genomic Sci. 1:21-28(2009).
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00407};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
DR   EMBL; CP001618; ACQ78537.1; -; Genomic_DNA.
DR   RefSeq; WP_012725317.1; NC_012669.1.
DR   SMR; C5BW79; -.
DR   STRING; 471853.Bcav_0272; -.
DR   PRIDE; C5BW79; -.
DR   EnsemblBacteria; ACQ78537; ACQ78537; Bcav_0272.
DR   KEGG; bcv:Bcav_0272; -.
DR   eggNOG; ENOG4107RYT; Bacteria.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000036008; -.
DR   KO; K10747; -.
DR   OMA; WLFEESY; -.
DR   OrthoDB; POG091H0BGA; -.
DR   BioCyc; BCAV471853:G1GET-271-MONOMER; -.
DR   Proteomes; UP000007962; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   HAMAP; MF_00407; DNA_ligase; 1.
DR   InterPro; IPR022865; DNA_ligae_ATP-dep_bac/arc.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    512       Probable DNA ligase.
FT                                /FTId=PRO_1000205954.
FT   ACT_SITE    219    219       N6-AMP-lysine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     217    217       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     224    224       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     239    239       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     268    268       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     306    306       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     377    377       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     383    383       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
SQ   SEQUENCE   512 AA;  53976 MW;  EC4172653DFF126F CRC64;
     MLLAEVAATS DAVAATRSRL AKRAAIADLL RRAPADDVEI VVAYVAGELR QRRTGLGWRS
     LRDLPGPAED PSLEVADVDA TFAAMADLAG PGSATARAAA AAELFAAATE REQALLRGLV
     SGELRQGALD ALVLDAVADA AGVPAPEVRR AAMFAGATGP VARAALAAAG PAEAVAALSG
     FMLTVGRAVR PMLAQSAPDV AAAFAKLPGG DVAVSVDVKL DGIRIQVHKA GDEVRVFTRS
     LDDITGRVPE IVEAVRALPA GALVLDGEAL AVDAGGRPRP FQETASRSAT RDADVAAAMT
     LTPFFFDCLH ADGRDLVDAP LRERLEVLDA VAGPHVVTRL TTSDPAAAEE FFAAAVRDGQ
     EGVVVKATDT PYEAGRRGAG WIKVKPRHTL DLVVLAVEWG SGRRRGWLSN IHLGARDPAG
     GFVMLGKTFK GMTDEMLAWQ TERFLELETS RDEWAVHLRP EQVVEIAFDG LQRSTRYPGG
     LALRFARVLR YRDDKTAAEA DTIDTVRTLA GL
//
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