GenomeNet

Database: UniProt/SWISS-PROT
Entry: DNLI_MYCGI
LinkDB: DNLI_MYCGI
Original site: DNLI_MYCGI 
ID   DNLI_MYCGI              Reviewed;         511 AA.
AC   A4TDS2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   20-JUN-2018, entry version 89.
DE   RecName: Full=Probable DNA ligase {ECO:0000255|HAMAP-Rule:MF_00407};
DE            EC=6.5.1.1 {ECO:0000255|HAMAP-Rule:MF_00407};
DE   AltName: Full=Polydeoxyribonucleotide synthase [ATP] {ECO:0000255|HAMAP-Rule:MF_00407};
GN   Name=lig {ECO:0000255|HAMAP-Rule:MF_00407};
GN   OrderedLocusNames=Mflv_4321;
OS   Mycobacterium gilvum (strain PYR-GCK) (Mycobacterium flavescens
OS   (strain ATCC 700033 / PYR-GCK)).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350054;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PYR-GCK;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium gilvum PYR-GCK.";
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: DNA ligase that seals nicks in double-stranded DNA
CC       during DNA replication, DNA recombination and DNA repair.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000255|HAMAP-Rule:MF_00407}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00407};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00407}.
DR   EMBL; CP000656; ABP46790.1; -; Genomic_DNA.
DR   RefSeq; WP_011895165.1; NC_009338.1.
DR   SMR; A4TDS2; -.
DR   STRING; 350054.Mflv_4321; -.
DR   PRIDE; A4TDS2; -.
DR   EnsemblBacteria; ABP46790; ABP46790; Mflv_4321.
DR   KEGG; mgi:Mflv_4321; -.
DR   eggNOG; ENOG4107RYT; Bacteria.
DR   eggNOG; COG1793; LUCA.
DR   HOGENOM; HOG000036008; -.
DR   KO; K10747; -.
DR   OMA; WLFEESY; -.
DR   OrthoDB; POG091H0BGA; -.
DR   Proteomes; UP000000232; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   HAMAP; MF_00407; DNA_ligase; 1.
DR   InterPro; IPR022865; DNA_ligae_ATP-dep_bac/arc.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA recombination; DNA repair; DNA replication; Ligase; Magnesium;
KW   Metal-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN         1    511       Probable DNA ligase.
FT                                /FTId=PRO_0000365224.
FT   ACT_SITE    211    211       N6-AMP-lysine intermediate.
FT                                {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     209    209       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     216    216       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     231    231       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     260    260       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     299    299       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     371    371       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
FT   BINDING     377    377       ATP. {ECO:0000255|HAMAP-Rule:MF_00407}.
SQ   SEQUENCE   511 AA;  54366 MW;  DD54BAD356E34B39 CRC64;
     MLLVDVAGAS ADVAASSARL AKIARIAELL RRAGREDVAI VVSWLSGELT QRQIGVGWAS
     LRSVPAAAAE PTLTVAEVER RFGEIGATAG RGSQARRAQL LADLFSAATD VEQTFLRRLL
     TGELRQGALV GVMADAVAKA ADLPAATVRR AAMLGGDLPA VAAAALTDGD AGLAQFTLQA
     GKAVGPMLAQ TAADVTDALD RLGGTAMFEA KLDGARVQIH RRGDSVSIFT RSLDDVTARL
     PEVVEATLAL PVTDLIADAE AIALRPDGRP HRFQVTASRF GRRGGTSDTA SNPLSVFFFD
     LLHVDGVDLL DAPAHERIAR LDAVTPDSQR VDRLVTSDPG AAQEFFDRTL AAGHEGVMAK
     STVAPYEAGR RGAGWLKVKP VHTLDLVVLA VEWGSGRRSG KLSNIHLGAR DPGTGGFVML
     GKTFKGMTDE MLAWQTRRFL DLADGDATDH YVVKVRPEQV VEIAFDGLQT STRYPGGMAL
     RFARVVRYRD DKAATDADTI DTVREIYERG N
//
DBGET integrated database retrieval system