ID ECSB_BACSU Reviewed; 408 AA.
AC P55340;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE RecName: Full=Protein EcsB;
GN Name=ecsB; Synonyms=prsT, yhaC; OrderedLocusNames=BSU10050;
OS Bacillus subtilis (strain 168).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8581172; DOI=10.1099/13500872-142-1-71;
RA Leskela S., Kontinen V.P., Sarvas M.;
RT "Molecular analysis of an operon in Bacillus subtilis encoding a novel ABC
RT transporter with a role in exoprotein production, sporulation and
RT competence.";
RL Microbiology 142:71-77(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [4]
RP ROLE IN FORMATION OF BIOFILMS, AND DISRUPTION PHENOTYPE.
RC STRAIN=168, and 3610;
RX PubMed=15175311; DOI=10.1128/jb.186.12.3970-3979.2004;
RA Branda S.S., Gonzalez-Pastor J.E., Dervyn E., Ehrlich S.D., Losick R.,
RA Kolter R.;
RT "Genes involved in formation of structured multicellular communities by
RT Bacillus subtilis.";
RL J. Bacteriol. 186:3970-3979(2004).
CC -!- FUNCTION: Presumed to form part of an ABC-transporter, it may form a
CC transport channel. {ECO:0000269|PubMed:15175311}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Cells form colonies in which certain
CC architectural features are absent or less prominent than those observed
CC in wild-type colonies. The Ecs activity could be important for the
CC development of communities. {ECO:0000269|PubMed:15175311}.
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DR EMBL; X87807; CAA61075.1; -; Genomic_DNA.
DR EMBL; Y14077; CAA74408.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12845.1; -; Genomic_DNA.
DR PIR; G69619; G69619.
DR RefSeq; NP_388886.1; NC_000964.3.
DR RefSeq; WP_003245169.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P55340; -.
DR STRING; 224308.BSU10050; -.
DR TCDB; 3.A.1.143.1; the atp-binding cassette (abc) superfamily.
DR jPOST; P55340; -.
DR PaxDb; 224308-BSU10050; -.
DR EnsemblBacteria; CAB12845; CAB12845; BSU_10050.
DR GeneID; 939298; -.
DR KEGG; bsu:BSU10050; -.
DR PATRIC; fig|224308.179.peg.1081; -.
DR eggNOG; COG4473; Bacteria.
DR InParanoid; P55340; -.
DR OrthoDB; 2447941at2; -.
DR PhylomeDB; P55340; -.
DR BioCyc; BSUB:BSU10050-MONOMER; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR InterPro; IPR010288; EcsB_ABC.
DR Pfam; PF05975; EcsB; 1.
DR PIRSF; PIRSF037259; EcsB_ABC; 1.
PE 4: Predicted;
KW Cell membrane; Competence; Membrane; Reference proteome; Sporulation;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..408
FT /note="Protein EcsB"
FT /id="PRO_0000086926"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 351..371
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 408 AA; 47300 MW; 344628E5A3E7DAAE CRC64;
MNNMLDIWQS RLQEHIKETR TYMKYMLNDH LVIVLIFFLA GAASWYSKWI RDIPAHFPSF
WVMAVLFSLV LTSSYVRTLL KEADLVFLLP LEAKMEPYLK QAFVYSYVSQ LFPLIALSIV
AMPLYFAVTP GASLVSYAAV FVQLLLLKAW NQVMEWRTTF QNDRSMKRMD VIIRFAANTL
VLYFVFQSVY MYALLVYVIM AVLYLYMSSA AKRKTFKWES HIESELRRKQ RFYRIANLFT
DVPHLRKQAK RRAYLDFLLR LVPFEQRKTF AYMFTRAFLR SSDYLGILVR LTIVFALIIM
YVSASPLIAA VLTVFAIFIT GIQLLPLFGH FDHLALQELY PVQKETKLKS YFSLLKTALS
IQALLMSVAS AYAAGLTGFL YALIGSAVLI FVVLPAYMTT RLKKHGKL
//
