GenomeNet

Database: UniProt/SWISS-PROT
Entry: EFTU_BACHD
LinkDB: EFTU_BACHD
Original site: EFTU_BACHD 
ID   EFTU_BACHD              Reviewed;         396 AA.
AC   Q9Z9L6; Q9JPY8;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   16-JAN-2019, entry version 119.
DE   RecName: Full=Elongation factor Tu {ECO:0000255|HAMAP-Rule:MF_00118};
DE            Short=EF-Tu {ECO:0000255|HAMAP-Rule:MF_00118};
GN   Name=tuf {ECO:0000255|HAMAP-Rule:MF_00118}; Synonyms=tufA;
GN   OrderedLocusNames=BH0132;
OS   Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM
OS   9153 / C-125).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=10192928; DOI=10.1271/bbb.63.452;
RA   Takami H., Takaki Y., Nakasone K., Hirama C., Inoue A., Horikoshi K.;
RT   "Sequence analysis of a 32-kb region including the major ribosomal
RT   protein gene clusters from alkaliphilic Bacillus sp. strain C-125.";
RL   Biosci. Biotechnol. Biochem. 63:452-455(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N.,
RA   Fuji F., Hirama C., Nakamura Y., Ogasawara N., Kuhara S.,
RA   Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus
RT   halodurans and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: This protein promotes the GTP-dependent binding of
CC       aminoacyl-tRNA to the A-site of ribosomes during protein
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00118}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00118}.
DR   EMBL; AB017508; BAA75269.1; -; Genomic_DNA.
DR   EMBL; BA000004; BAB03851.1; -; Genomic_DNA.
DR   PIR; T44381; T44381.
DR   RefSeq; WP_010896315.1; NC_002570.2.
DR   ProteinModelPortal; Q9Z9L6; -.
DR   SMR; Q9Z9L6; -.
DR   STRING; 272558.BH0132; -.
DR   PRIDE; Q9Z9L6; -.
DR   EnsemblBacteria; BAB03851; BAB03851; BAB03851.
DR   KEGG; bha:BH0132; -.
DR   eggNOG; ENOG4105CGV; Bacteria.
DR   eggNOG; COG0050; LUCA.
DR   KO; K02358; -.
DR   OMA; YGHIDCP; -.
DR   OrthoDB; 621774at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd03697; EFTU_II; 1.
DR   HAMAP; MF_00118_B; EF_Tu_B; 1.
DR   InterPro; IPR004161; EFTu-like_2.
DR   InterPro; IPR033720; EFTU_2.
DR   InterPro; IPR031157; G_TR_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; TF_GTP-bd_dom.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR   InterPro; IPR004541; Transl_elong_EFTu/EF1A_bac/org.
DR   InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF03144; GTP_EFTU_D2; 1.
DR   Pfam; PF03143; GTP_EFTU_D3; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF50447; SSF50447; 1.
DR   SUPFAM; SSF50465; SSF50465; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00485; EF-Tu; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS00301; G_TR_1; 1.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Elongation factor; GTP-binding;
KW   Nucleotide-binding; Protein biosynthesis; Reference proteome.
FT   CHAIN         1    396       Elongation factor Tu.
FT                                /FTId=PRO_0000091289.
FT   DOMAIN       10    205       tr-type G.
FT   NP_BIND      19     26       GTP. {ECO:0000255|HAMAP-Rule:MF_00118}.
FT   NP_BIND      82     86       GTP. {ECO:0000255|HAMAP-Rule:MF_00118}.
FT   NP_BIND     137    140       GTP. {ECO:0000255|HAMAP-Rule:MF_00118}.
FT   REGION       19     26       G1. {ECO:0000250}.
FT   REGION       61     65       G2. {ECO:0000250}.
FT   REGION       82     85       G3. {ECO:0000250}.
FT   REGION      137    140       G4. {ECO:0000250}.
FT   REGION      175    177       G5. {ECO:0000250}.
SQ   SEQUENCE   396 AA;  43383 MW;  4F6ABACEE2296079 CRC64;
     MAKEKFDRSK THANIGTIGH VDHGKTTLTA AITTVLAKRS GKGVAMAYDA IDGAPEERER
     GITISTAHVE YETDNRHYAH VDCPGHADYV KNMITGAAQM DGGILVVSAA DGPMPQTREH
     ILLSRQVGVP YLVVFLNKCD MVDDEELLEL VEMEVRDLLS EYDFPGDDVP VIRGSALKAL
     EGDAEWEEKI IELMAAVDDY IPTPERDTEK PFMMPVEDVF SITGRGTVAT GRVERGQLNV
     GDEVEIIGLE EEAKKTTVTG VEMFRKLLDY AEAGDNIGAL LRGVSREEVQ RGQVLAKPGT
     ITPHTNFKAE VYVLSKEEGG RHTPFFSNYR PQFYFRTTDV TGIIQLPDGV EMVMPGDNVE
     MTVELIAPIA IEEGTKFSIR EGGRTVGAGV VASIQK
//
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