ID ESF2_NEOFI Reviewed; 365 AA.
AC A1DIN9;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Pre-rRNA-processing protein esf2;
DE AltName: Full=18S rRNA factor 2;
GN Name=esf2; ORFNames=NFIA_092060;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Involved in the small subunit (SSU) processome assembly and
CC function, and in the 18S rRNA synthesis. Required for the early
CC cleavages at sites A0, A1 and A2 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ESF2/ABP1 family. {ECO:0000305}.
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DR EMBL; DS027696; EAW19246.1; -; Genomic_DNA.
DR RefSeq; XP_001261143.1; XM_001261142.1.
DR AlphaFoldDB; A1DIN9; -.
DR STRING; 331117.A1DIN9; -.
DR EnsemblFungi; EAW19246; EAW19246; NFIA_092060.
DR GeneID; 4587701; -.
DR KEGG; nfi:NFIA_092060; -.
DR VEuPathDB; FungiDB:NFIA_092060; -.
DR eggNOG; KOG3152; Eukaryota.
DR HOGENOM; CLU_054086_0_1_1; -.
DR OMA; TRKHNDF; -.
DR OrthoDB; 5481521at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR CDD; cd12263; RRM_ABT1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR039119; ABT1/Esf2.
DR InterPro; IPR034353; ABT1/ESF2_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR PANTHER; PTHR12311; ACTIVATOR OF BASAL TRANSCRIPTION 1; 1.
DR PANTHER; PTHR12311:SF7; ACTIVATOR OF BASAL TRANSCRIPTION 1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW rRNA processing.
FT CHAIN 1..365
FT /note="Pre-rRNA-processing protein esf2"
FT /id="PRO_0000285375"
FT DOMAIN 149..239
FT /note="RRM"
FT REGION 1..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 365 AA; 40963 MW; 1B13B716DBB816EA CRC64;
MTTRKRNEFL DIVSDDDEGS DRGYDSAAAE ESKGRLAKRR KTHTRADDLS DEESDFGRSE
SEDESKTRLK GKPKSKSQTT ERSNDSDDED EADDGEKMQV DQYLDTTAAH SPSQSRSQSP
SASSVSSKPT KLKKKPLDKV RPPKKNKTGV IYLSSLPPYL KPFALKSMLE TRGFGPITKV
FLTPEVPSNS APRRRSNKRK SYADGWVEFA SKKTAKICAE TLNATIVGGK KGGWYHDDVW
NMKYLKGFKW ADLMEQVQRE RSEREAKRRI EDTRARKEDK VFLQGVEQGK VLQGIQKKNE
EKKKKKGETG PGEGEGSADA AAAAAASELK VRRLFKQSEV KMGRDKVKDI STLEDDAKRV
LSKIF
//
