ID F16PC_STRA1 Reviewed; 643 AA.
AC Q3K2F6;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Fructose-1,6-bisphosphatase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE Short=FBPase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
DE EC=3.1.3.11 {ECO:0000255|HAMAP-Rule:MF_01854};
DE AltName: Full=D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 {ECO:0000255|HAMAP-Rule:MF_01854};
GN Name=fbp {ECO:0000255|HAMAP-Rule:MF_01854}; OrderedLocusNames=SAK_0666;
OS Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC
OS SS700).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=205921;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 27591 / A909 / CDC SS700;
RX PubMed=16172379; DOI=10.1073/pnas.0506758102;
RA Tettelin H., Masignani V., Cieslewicz M.J., Donati C., Medini D.,
RA Ward N.L., Angiuoli S.V., Crabtree J., Jones A.L., Durkin A.S., DeBoy R.T.,
RA Davidsen T.M., Mora M., Scarselli M., Margarit y Ros I., Peterson J.D.,
RA Hauser C.R., Sundaram J.P., Nelson W.C., Madupu R., Brinkac L.M.,
RA Dodson R.J., Rosovitz M.J., Sullivan S.A., Daugherty S.C., Haft D.H.,
RA Selengut J., Gwinn M.L., Zhou L., Zafar N., Khouri H., Radune D.,
RA Dimitrov G., Watkins K., O'Connor K.J., Smith S., Utterback T.R., White O.,
RA Rubens C.E., Grandi G., Madoff L.C., Kasper D.L., Telford J.L.,
RA Wessels M.R., Rappuoli R., Fraser C.M.;
RT "Genome analysis of multiple pathogenic isolates of Streptococcus
RT agalactiae: implications for the microbial 'pan-genome'.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13950-13955(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-
CC phosphate + phosphate; Xref=Rhea:RHEA:11064, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:32966, ChEBI:CHEBI:43474, ChEBI:CHEBI:57634; EC=3.1.3.11;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01854};
CC -!- PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
CC {ECO:0000255|HAMAP-Rule:MF_01854}.
CC -!- SIMILARITY: Belongs to the FBPase class 3 family. {ECO:0000255|HAMAP-
CC Rule:MF_01854}.
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DR EMBL; CP000114; ABA46271.1; -; Genomic_DNA.
DR RefSeq; WP_000064640.1; NC_007432.1.
DR AlphaFoldDB; Q3K2F6; -.
DR KEGG; sak:SAK_0666; -.
DR HOGENOM; CLU_028392_2_0_9; -.
DR UniPathway; UPA00138; -.
DR GO; GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.60.21.10; -; 1.
DR HAMAP; MF_01854; FBPase_class3; 1.
DR InterPro; IPR009164; FBPtase_class3.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF06874; FBPase_2; 1.
DR PIRSF; PIRSF000906; FBPtase_Bacill; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Hydrolase; Manganese.
FT CHAIN 1..643
FT /note="Fructose-1,6-bisphosphatase class 3"
FT /id="PRO_0000363112"
SQ SEQUENCE 643 AA; 74921 MW; F687C2C2453BE4DA CRC64;
MSNFYKLLKE KFPRKEDIVT EMINLEAICQ LPKGTEYFIS DLHGEYDAVD YLLRTGAGSI
RAKLLDCFDW QKIVAVDLDD FCILLYYPKE KLAFDKMNLS ASAYKTKLWE MIPLQIQVLK
YFSSKYTKSK VRKQLSGKFA YIIEELLAEI DRNPEKKSYF DTIIEKLFEL DQVEDLIIVL
SQTIQVLIID HLHVVGDIYD RGRYPDRILN RLMAFPNLDI QWGNHDVTWM GAASGSYLCM
VNVIRIAARY NNITLIEDRY GINLRRLVDY SRRYYEPLPS FVPILDGEEM THPDELDLLN
MIQQATAILQ FKLEAQLIDR RPEFQMHNRQ LINQVNYKDL SISIKEVVHQ LKDFNSRCID
SKNPSRLTSE EEELLQQLMI AFQTSESLKK HIDFLFEKGS MYLTYNDNLL FHGCIPMHSN
GDFKSFKIAG KTYGGRDLLD LFESQIRLAY ARPEKHDDLA TDIIWYLWCG ENSSLFGKNA
MTTFERYYVS DKVTHQERKN PYFKLRDKDD ICTALLQEFD LPKFGHIVNG HTPVKEKNGE
QPIKANGKML VIDGGFAKGY QKNTGLAGYT LIYNSYGIQL ISHLPFTSIE EVLSGTNYII
DTKRLVEEAK DRILVKDTTI GQKLTKEIKD LDHLYRHFQE YDD
//
