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Database: UniProt/SWISS-PROT
Entry: FABZ_PSEAE
LinkDB: FABZ_PSEAE
Original site: FABZ_PSEAE 
ID   FABZ_PSEAE              Reviewed;         146 AA.
AC   Q9HXY7;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   08-MAY-2019, entry version 107.
DE   RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ {ECO:0000255|HAMAP-Rule:MF_00406};
DE            EC=4.2.1.59 {ECO:0000255|HAMAP-Rule:MF_00406};
DE   AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
DE            Short=(3R)-hydroxymyristoyl-ACP dehydrase {ECO:0000255|HAMAP-Rule:MF_00406};
DE   AltName: Full=Beta-hydroxyacyl-ACP dehydratase {ECO:0000255|HAMAP-Rule:MF_00406};
GN   Name=fabZ {ECO:0000255|HAMAP-Rule:MF_00406}; OrderedLocusNames=PA3645;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /
OS   JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
RA   Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an
RT   opportunistic pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis.
CC       Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and
CC       long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
CC       {ECO:0000255|HAMAP-Rule:MF_00406}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC         Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827;
CC         EC=4.2.1.59; Evidence={ECO:0000255|HAMAP-Rule:MF_00406};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00406}.
CC   -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00406}.
DR   EMBL; AE004091; AAG07033.1; -; Genomic_DNA.
DR   PIR; E83190; E83190.
DR   RefSeq; NP_252335.1; NC_002516.2.
DR   RefSeq; WP_003092375.1; NZ_QZGE01000001.1.
DR   PDB; 1U1Z; X-ray; 2.50 A; A/B/C/D/E/F=1-146.
DR   PDBsum; 1U1Z; -.
DR   SMR; Q9HXY7; -.
DR   PaxDb; Q9HXY7; -.
DR   PRIDE; Q9HXY7; -.
DR   DNASU; 880494; -.
DR   EnsemblBacteria; AAG07033; AAG07033; PA3645.
DR   GeneID; 880494; -.
DR   KEGG; pae:PA3645; -.
DR   PATRIC; fig|208964.12.peg.3814; -.
DR   PseudoCAP; PA3645; -.
DR   eggNOG; ENOG4108YXN; Bacteria.
DR   eggNOG; COG0764; LUCA.
DR   HOGENOM; HOG000277829; -.
DR   InParanoid; Q9HXY7; -.
DR   KO; K02372; -.
DR   OMA; FPGRPLM; -.
DR   PhylomeDB; Q9HXY7; -.
DR   BioCyc; PAER208964:G1FZ6-3715-MONOMER; -.
DR   EvolutionaryTrace; Q9HXY7; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00406; FabZ; 1.
DR   InterPro; IPR013114; FabA_FabZ.
DR   InterPro; IPR010084; FabZ.
DR   InterPro; IPR029069; HotDog_dom_sf.
DR   Pfam; PF07977; FabA; 1.
DR   SUPFAM; SSF54637; SSF54637; 1.
DR   TIGRFAMs; TIGR01750; fabZ; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Complete proteome; Cytoplasm; Lipid A biosynthesis;
KW   Lipid biosynthesis; Lipid metabolism; Lyase; Reference proteome.
FT   CHAIN         1    146       3-hydroxyacyl-[acyl-carrier-protein]
FT                                dehydratase FabZ.
FT                                /FTId=PRO_0000091713.
FT   ACT_SITE     49     49       {ECO:0000255|HAMAP-Rule:MF_00406}.
FT   HELIX         4      7       {ECO:0000244|PDB:1U1Z}.
FT   TURN          8     10       {ECO:0000244|PDB:1U1Z}.
FT   STRAND       22     27       {ECO:0000244|PDB:1U1Z}.
FT   TURN         28     31       {ECO:0000244|PDB:1U1Z}.
FT   STRAND       32     38       {ECO:0000244|PDB:1U1Z}.
FT   HELIX        46     48       {ECO:0000244|PDB:1U1Z}.
FT   HELIX        58     77       {ECO:0000244|PDB:1U1Z}.
FT   STRAND       86     97       {ECO:0000244|PDB:1U1Z}.
FT   STRAND      106    117       {ECO:0000244|PDB:1U1Z}.
FT   STRAND      120    129       {ECO:0000244|PDB:1U1Z}.
FT   STRAND      132    144       {ECO:0000244|PDB:1U1Z}.
SQ   SEQUENCE   146 AA;  16774 MW;  BC7D53E61F5E44CB CRC64;
     MMDINEIREY LPHRYPFLLV DRVVELDIEG KRIRAYKNVS INEPFFNGHF PEHPIMPGVL
     IIEAMAQAAG ILGFKMLDVK PADGTLYYFV GSDKLRFRQP VLPGDQLQLH AKFISVKRSI
     WKFDCHATVD DKPVCSAEII CAERKL
//
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