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Database: UniProt/SWISS-PROT
Entry: HDAC1_CHICK
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Original site: HDAC1_CHICK 
ID   HDAC1_CHICK             Reviewed;         480 AA.
AC   P56517;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   23-MAY-2018, entry version 131.
DE   RecName: Full=Histone deacetylase 1;
DE            Short=HD1;
DE            EC=3.5.1.98;
GN   Name=HDAC1; Synonyms=HDAC1A;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
OC   Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takami Y.;
RL   Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Sun J.M., Chen H.Y., Davie J.R.;
RL   Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Responsible for the deacetylation of lysine residues on
CC       the N-terminal part of the core histones (H2A, H2B, H3 and H4).
CC       Histone deacetylation gives a tag for epigenetic repression and
CC       plays an important role in transcriptional regulation, cell cycle
CC       progression and developmental events. Histone deacetylases act via
CC       the formation of large multiprotein complexes (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC   -!- SUBUNIT: Forms a complex with RBAP48. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. HD type 1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AF039751; AAB96923.1; -; mRNA.
DR   EMBL; AF043328; AAB99850.1; -; mRNA.
DR   EMBL; AF044169; AAC00504.1; -; mRNA.
DR   RefSeq; NP_989487.1; NM_204156.1.
DR   UniGene; Gga.10603; -.
DR   ProteinModelPortal; P56517; -.
DR   SMR; P56517; -.
DR   BioGrid; 675010; 2.
DR   STRING; 9031.ENSGALP00000005212; -.
DR   PaxDb; P56517; -.
DR   PRIDE; P56517; -.
DR   Ensembl; ENSGALT00000084635; ENSGALP00000059784; ENSGALG00000003297.
DR   GeneID; 373961; -.
DR   KEGG; gga:373961; -.
DR   CTD; 3065; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   eggNOG; COG0123; LUCA.
DR   GeneTree; ENSGT00910000144047; -.
DR   HOGENOM; HOG000225180; -.
DR   HOVERGEN; HBG057112; -.
DR   InParanoid; P56517; -.
DR   KO; K06067; -.
DR   OMA; LWAYETS; -.
DR   OrthoDB; EOG091G067J; -.
DR   PhylomeDB; P56517; -.
DR   TreeFam; TF106171; -.
DR   BRENDA; 3.5.1.98; 1306.
DR   Reactome; R-GGA-1538133; G0 and Early G1.
DR   Reactome; R-GGA-201722; Formation of the beta-catenin:TCF transactivating complex.
DR   Reactome; R-GGA-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
DR   Reactome; R-GGA-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Reactome; R-GGA-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-GGA-6804758; Regulation of TP53 Activity through Acetylation.
DR   Reactome; R-GGA-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-GGA-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-GGA-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-GGA-9018519; Estrogen-dependent gene expression.
DR   Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
DR   PRO; PR:P56517; -.
DR   Proteomes; UP000000539; Chromosome 23.
DR   Bgee; ENSGALG00000003297; -.
DR   GO; GO:0005737; C:cytoplasm; TAS:UniProtKB.
DR   GO; GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; TAS:UniProtKB.
DR   GO; GO:0004407; F:histone deacetylase activity; TAS:UniProtKB.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0008134; F:transcription factor binding; TAS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; TAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR003084; His_deacetylse_1.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PIRSF; PIRSF037913; His_deacetylse_1; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PRINTS; PR01271; HISDACETLASE.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Complete proteome; Hydrolase; Nucleus;
KW   Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    480       Histone deacetylase 1.
FT                                /FTId=PRO_0000114689.
FT   REGION        9    321       Histone deacetylase.
FT   COMPBIAS    299    302       Poly-Gly.
FT   COMPBIAS    396    399       Poly-Glu.
FT   COMPBIAS    446    453       Poly-Glu.
FT   ACT_SITE    141    141       {ECO:0000250}.
FT   CONFLICT      3      4       LT -> VM (in Ref. 2; AAB99850).
FT                                {ECO:0000305}.
SQ   SEQUENCE   480 AA;  54939 MW;  82C78CE285C779D9 CRC64;
     MALTQGTKRK VCYYYDGDVG NYYYGQGHPM KPHRIRMTHN LLLNYGLYRK MEIYRPHKAN
     AEEMTKYHSD DYIKFLRSIR PDNMSEYSKQ MQRFNVGEDC PVFDGLFEFC QLSAGGSVAS
     AVKLNKQQTD IAVNWAGGLH HAKKSEASGF CYVNDIVLAI LELLKYHQRV LYIDIDIHHG
     DGVEEAFYTT DRVMTVSFHK YGEYFPGTGD LRDIGAGKGK YYAVNYPLRD GIDDESYEAI
     FKPVISKVME TFQPSAVVLQ CGSDSLSGDR LGCFNLTIKG HAKCVEFVKS FNLPMLMLGG
     GGYTIRNVAR CWTYETAVAL DTEIPNELPY NDYFEYFGPD FKLHISPSNM TNQNTNEYLE
     KIKQRLFENL RMLPHAPGVQ MQPIPEDAVQ EDSGDEEEED PEKRISIRNS DKRISCDEEF
     SDSEDEGEGG RKNVANFKKA KRVKTEEEKE EEEKKDEKEE EKAKEEKAEP KGVKEETKST
//
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