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Database: UniProt/SWISS-PROT
Entry: HXK4_ORYSJ
LinkDB: HXK4_ORYSJ
Original site: HXK4_ORYSJ 
ID   HXK4_ORYSJ              Reviewed;         509 AA.
AC   Q6Z398; Q0D7Y5; Q94JW5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-MAY-2018, entry version 78.
DE   RecName: Full=Hexokinase-4, chloroplastic;
DE            EC=2.7.1.1;
DE   AltName: Full=Hexokinase II;
DE   Flags: Precursor;
GN   Name=HXK4;
GN   OrderedLocusNames=Os07g0197100 {ECO:0000312|EMBL:BAF21038.1},
GN   LOC_Os07g09890 {ECO:0000305};
GN   ORFNames=OsJ_23449 {ECO:0000312|EMBL:EAZ39028.1}, P0417F02.7,
GN   P0589E08.26;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, AND NOMENCLATURE.
RC   STRAIN=cv. Jinmi;
RX   PubMed=16552590; DOI=10.1007/s00425-006-0251-y;
RA   Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H.,
RA   Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.;
RT   "Structure, expression, and functional analysis of the hexokinase gene
RT   family in rice (Oryza sativa L.).";
RL   Planta 224:598-611(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wu P., Jiang H.-W., Yi K.-K.;
RT   "Rice hexokinase II mRNA.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H.,
RA   McCombie W.R., Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S.,
RA   Childs K.L., Davidson R.M., Lin H., Quesada-Ocampo L.,
RA   Vaillancourt B., Sakai H., Lee S.S., Kim J., Numa H., Itoh T.,
RA   Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using
RT   next generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H.,
RA   Cong L., Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J.,
RA   Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X.,
RA   Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y.,
RA   Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J.,
RA   Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y.,
RA   Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y.,
RA   Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z.,
RA   Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T.,
RA   Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H.,
RA   Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W.,
RA   Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L.,
RA   Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J.,
RA   Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
CC   -!- FUNCTION: Fructose and glucose phosphorylating enzyme.
CC       {ECO:0000269|PubMed:16552590}.
CC   -!- CATALYTIC ACTIVITY: ATP + D-hexose = ADP + D-hexose 6-phosphate.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma
CC       {ECO:0000305|PubMed:16552590}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaves, flowers, immature
CC       seeds, endosperm and seed coat. {ECO:0000269|PubMed:16552590}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during flower development until 8
CC       days after flowering. {ECO:0000269|PubMed:16552590}.
CC   -!- INDUCTION: Not induced by glucose or fructose treatment in leaves.
CC       {ECO:0000269|PubMed:16552590}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01084, ECO:0000305}.
DR   EMBL; DQ116386; AAZ93621.1; -; mRNA.
DR   EMBL; AF372832; AAK51560.1; -; mRNA.
DR   EMBL; AP004379; BAD30694.1; -; Genomic_DNA.
DR   EMBL; AP005257; BAC84178.1; -; Genomic_DNA.
DR   EMBL; AP008213; BAF21038.1; -; Genomic_DNA.
DR   EMBL; AP014963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM000144; EAZ39028.1; -; Genomic_DNA.
DR   RefSeq; XP_015645316.1; XM_015789830.1.
DR   UniGene; Os.3294; -.
DR   ProteinModelPortal; Q6Z398; -.
DR   SMR; Q6Z398; -.
DR   STRING; 39947.LOC_Os07g09890.1; -.
DR   PaxDb; Q6Z398; -.
DR   GeneID; 4342654; -.
DR   KEGG; osa:4342654; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   HOGENOM; HOG000162670; -.
DR   InParanoid; Q6Z398; -.
DR   KO; K00844; -.
DR   BRENDA; 2.7.1.1; 4460.
DR   Reactome; R-OSA-170822; Regulation of Glucokinase by Glucokinase Regulatory Protein.
DR   Reactome; R-OSA-6798695; Neutrophil degranulation.
DR   Reactome; R-OSA-70171; Glycolysis.
DR   Proteomes; UP000059680; Chromosome 7.
DR   ExpressionAtlas; Q6Z398; differential.
DR   GO; GO:0009570; C:chloroplast stroma; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chloroplast; Complete proteome; Glycolysis; Kinase;
KW   Nucleotide-binding; Plastid; Reference proteome; Transferase;
KW   Transit peptide.
FT   TRANSIT       1     37       Chloroplast. {ECO:0000255}.
FT   CHAIN        38    509       Hexokinase-4, chloroplastic.
FT                                /FTId=PRO_0000247567.
FT   DOMAIN       45    496       Hexokinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01084}.
FT   NP_BIND     111    116       ATP. {ECO:0000255}.
FT   REGION      100    238       Hexokinase small subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   REGION      181    207       Glucose-binding. {ECO:0000255}.
FT   REGION      239    485       Hexokinase large subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
SQ   SEQUENCE   509 AA;  54759 MW;  C1DCA84034804BF8 CRC64;
     MSAAAAIASP IPAAIAVVQQ QRRGRSRGGG SGAAAVRCSA VAPTSAIAPI LADLRLRCAA
     PLPVLRRVAD AMASGMRAGL ADDGAGELKM IPSHVYSLPT GNETGLFYAL DLGGTNFRVL
     RVQLGGKDKR IIDTEFEQVS IPREIMHGIT EDLFDFIASG LSRFVATEGD KFHLPQGRKR
     ELGFTFSFPV NQTSIDSGIL IKWTKGFAVS GTAGKDVVAC LNAAMERQGL DMRVSALVND
     TVGTLAGARY WDDDVMVAVI LGTGTNACYI QRTEAIPKLQ HLKLETGNTI INTEWGAFSD
     GLPLTEFDRE MDDESINPGE QIFEKTISGM YLGEIVRRVL VKMAEVSDLF GHSFPKKLAE
     PFVLRTPHLC AMQQDTSDNL GEVESILSDV IGVSQASLLA RRVTVEVSDC IIRRGGRLAG
     AGIVGILEKM ENDSRGHIFG RRTVVAMDGG LYEKYPQYRR YMKEAVAELL GPERSNRIAI
     EHTKDGSGIG AALLAAANSK YAAAQISTR
//
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