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Database: UniProt/SWISS-PROT
Entry: HXK_EMENI
LinkDB: HXK_EMENI
Original site: HXK_EMENI 
ID   HXK_EMENI               Reviewed;         490 AA.
AC   P80581; C8VBD5; Q5AW71;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   26-MAY-2009, sequence version 2.
DT   05-DEC-2018, entry version 99.
DE   RecName: Full=Hexokinase;
DE            EC=2.7.1.1;
GN   Name=hxkA; ORFNames=AN7459;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL
OS   194 / M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P.,
RA   von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E.,
RA   Fekete E., Flipphi M., Estrada C.G., Geysens S., Goldman G.,
RA   de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K.,
RA   Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S.,
RA   Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E.,
RA   Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A.,
RA   Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P.,
RA   Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R.,
RA   Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I.,
RA   Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B.,
RA   van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N.,
RA   Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J.,
RA   de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W.,
RA   Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a
RT   community effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   PROTEIN SEQUENCE OF 210-331.
RC   STRAIN=biA1;
RX   PubMed=8674991; DOI=10.1111/j.1574-6968.1996.tb08206.x;
RA   Ruijter G.J.G., Panneman H., van den Broeck H.C., Bennett J.M.,
RA   Visser J.;
RT   "Characterisation of the Aspergillus nidulans frA1 mutant: hexose
RT   phosphorylation and apparent lack of involvement of hexokinase in
RT   glucose repression.";
RL   FEMS Microbiol. Lett. 139:223-228(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+);
CC         Xref=Rhea:RHEA:22740, ChEBI:CHEBI:4194, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61567, ChEBI:CHEBI:456216;
CC         EC=2.7.1.1;
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01084, ECO:0000305}.
DR   EMBL; AACD01000129; EAA62039.1; -; Genomic_DNA.
DR   EMBL; BN001304; CBF79423.1; -; Genomic_DNA.
DR   RefSeq; XP_680728.1; XM_675636.1.
DR   ProteinModelPortal; P80581; -.
DR   SMR; P80581; -.
DR   STRING; 162425.CADANIAP00000552; -.
DR   EnsemblFungi; CBF79423; CBF79423; ANIA_07459.
DR   EnsemblFungi; EAA62039; EAA62039; AN7459.2.
DR   GeneID; 2869351; -.
DR   KEGG; ani:AN7459.2; -.
DR   HOGENOM; HOG000162670; -.
DR   InParanoid; P80581; -.
DR   KO; K00844; -.
DR   OMA; ASHYVNP; -.
DR   OrthoDB; EOG092C2JW4; -.
DR   UniPathway; UPA00242; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   GO; GO:0019318; P:hexose metabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 1.
DR   Pfam; PF00349; Hexokinase_1; 1.
DR   Pfam; PF03727; Hexokinase_2; 1.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 1.
PE   1: Evidence at protein level;
KW   Allosteric enzyme; ATP-binding; Complete proteome;
KW   Direct protein sequencing; Glycolysis; Kinase; Nucleotide-binding;
KW   Reference proteome; Transferase.
FT   CHAIN         1    490       Hexokinase.
FT                                /FTId=PRO_0000197607.
FT   DOMAIN       21    466       Hexokinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01084}.
FT   REGION       75    209       Hexokinase small subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
FT   REGION      210    455       Hexokinase large subdomain.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01084}.
SQ   SEQUENCE   490 AA;  53925 MW;  2CA2F7F97B680812 CRC64;
     MVGVGPKRPP SRKGSMSDVP QNLLEHIKHF EEIFTVDTAT LKKIVDHFVN ELTKGLSVEG
     GNIPMNVTWV LGFPDGKETG TFLALDMGGT NLRVCEITLT EEKGGFDIIQ SKYRMPEELK
     TGEAEELWQY IVDCVEQFIQ FHHENENLSK LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI
     DGVEGKDVVP PLEKVFKERG LPIKVAALIN DTTGTLIASS YTDPAMKIGC IFGTGVNAAY
     MENAGSIPKL AHMNLPPDMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK
     MTAGLYLGEI FRLALVDILD TQPGLIFKDQ DTSQLRIPYL LDSSFPAAIE EDPYENLIET
     AELVQNMLKI KATRSELELM RRLAELIGTR AARLSACGVA AICKKKNIES CHVGADGSVF
     TKYPHFKARG AQALREILDW APSEKDKVTI HAAEDGSGVG AALIAALTLK RVKAGNTAGI
     RDAQAMLAMC
//
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