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Database: UniProt/SWISS-PROT
Entry: KITH_PORG3
LinkDB: KITH_PORG3
Original site: KITH_PORG3 
ID   KITH_PORG3              Reviewed;         204 AA.
AC   B2RJJ6;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   23-MAY-2018, entry version 53.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=PGN_1022;
OS   Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 /
OS   JCM 12257 / NCTC 11834 / 2561).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales;
OC   Porphyromonadaceae; Porphyromonas.
OX   NCBI_TaxID=431947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 /
RC   2561;
RX   PubMed=18524787; DOI=10.1093/dnares/dsn013;
RA   Naito M., Hirakawa H., Yamashita A., Ohara N., Shoji M., Yukitake H.,
RA   Nakayama K., Toh H., Yoshimura F., Kuhara S., Hattori M., Hayashi T.,
RA   Nakayama K.;
RT   "Determination of the genome sequence of Porphyromonas gingivalis
RT   strain ATCC 33277 and genomic comparison with strain W83 revealed
RT   extensive genome rearrangements in P. gingivalis.";
RL   DNA Res. 15:215-225(2008).
CC   -!- CATALYTIC ACTIVITY: ATP + thymidine = ADP + thymidine 5'-
CC       phosphate. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; AP009380; BAG33541.1; -; Genomic_DNA.
DR   RefSeq; WP_012457965.1; NZ_CP025930.1.
DR   ProteinModelPortal; B2RJJ6; -.
DR   SMR; B2RJJ6; -.
DR   STRING; 431947.PGN_1022; -.
DR   PRIDE; B2RJJ6; -.
DR   EnsemblBacteria; BAG33541; BAG33541; PGN_1022.
DR   GeneID; 29256232; -.
DR   KEGG; pgn:PGN_1022; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   BioCyc; PGIN431947:G1G2V-1155-MONOMER; -.
DR   Proteomes; UP000008842; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Transferase; Zinc.
FT   CHAIN         1    204       Thymidine kinase.
FT                                /FTId=PRO_1000095435.
FT   NP_BIND      23     30       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      95     98       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     96     96       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
FT   METAL       152    152       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       155    155       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       184    184       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       187    187       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   204 AA;  22711 MW;  356E60128AE63C43 CRC64;
     MDYEIENNHA DSIRRGSIEV ICGSMFSGKT EELLRRLRRA KIARQTVEIF KPTIDIRYDE
     TDVVSHDKNA IASAPVDNSA NILLLSSQVD VVGIDEAQFF DEGLVEVAQQ LADQGVRVVI
     AGLDMDFRRQ PFGPMPGLCA IADSVTKVHA VCVECGRLAS YSFRRVQGDQ QVMLGELNEY
     SPLCRTCYRK CSSPPQTEEI HSTI
//
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