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Database: UniProt/SWISS-PROT
Entry: KMT5B_DANRE
LinkDB: KMT5B_DANRE
Original site: KMT5B_DANRE 
ID   KMT5B_DANRE             Reviewed;         808 AA.
AC   Q5U3H2; Q1LWF0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   16-JAN-2019, entry version 101.
DE   RecName: Full=Histone-lysine N-methyltransferase KMT5B {ECO:0000305};
DE            EC=2.1.1.43;
DE   AltName: Full=Lysine-specific methyltransferase 5B {ECO:0000250|UniProtKB:Q4FZB7};
DE   AltName: Full=Suppressor of variegation 4-20 homolog 1;
DE            Short=Su(var)4-20 homolog 1;
DE            Short=Suv4-20h1;
GN   Name=kmt5b {ECO:0000250|UniProtKB:Q4FZB7}; Synonyms=suv420h1;
GN   ORFNames=si:dkey-12e7.2, zgc:103527;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G.,
RA   Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B.,
RA   Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S.,
RA   Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C.,
RA   Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H.,
RA   Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C.,
RA   Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J.,
RA   Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S.,
RA   Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R.,
RA   Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R.,
RA   Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R.,
RA   Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A.,
RA   Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S.,
RA   Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone methyltransferase that specifically
CC       trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation
CC       represents a specific tag for epigenetic transcriptional
CC       repression. Mainly functions in pericentric heterochromatin
CC       regions, thereby playing a central role in the establishment of
CC       constitutive heterochromatin in these regions. Plays a role in
CC       myogenesis by regulating the expression of target genes (By
CC       similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00903};
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000250}.
CC       Note=Associated with pericentric heterochromatin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00903}.
DR   EMBL; BX571884; CAK05146.1; -; Genomic_DNA.
DR   EMBL; BC085544; AAH85544.1; -; mRNA.
DR   RefSeq; NP_001007338.1; NM_001007337.2.
DR   RefSeq; XP_017207456.1; XM_017351967.1.
DR   UniGene; Dr.119113; -.
DR   ProteinModelPortal; Q5U3H2; -.
DR   SMR; Q5U3H2; -.
DR   STRING; 7955.ENSDARP00000060190; -.
DR   PaxDb; Q5U3H2; -.
DR   PRIDE; Q5U3H2; -.
DR   Ensembl; ENSDART00000060191; ENSDARP00000060190; ENSDARG00000041081.
DR   GeneID; 572849; -.
DR   KEGG; dre:572849; -.
DR   CTD; 51111; -.
DR   ZFIN; ZDB-GENE-041114-22; kmt5b.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00940000156431; -.
DR   HOGENOM; HOG000081769; -.
DR   HOVERGEN; HBG105761; -.
DR   InParanoid; Q5U3H2; -.
DR   KO; K11429; -.
DR   OMA; DGFRTAK; -.
DR   OrthoDB; 236983at2759; -.
DR   PhylomeDB; Q5U3H2; -.
DR   TreeFam; TF106433; -.
DR   Reactome; R-DRE-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q5U3H2; -.
DR   Proteomes; UP000000437; Chromosome 18.
DR   Bgee; ENSDARG00000041081; Expressed in 28 organ(s), highest expression level in retina.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   GO; GO:0034770; P:histone H4-K20 methylation; IGI:ZFIN.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:InterPro.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0040014; P:regulation of multicellular organism growth; IGI:ZFIN.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Myogenesis; Nucleus; Reference proteome; Repressor;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN         1    808       Histone-lysine N-methyltransferase KMT5B.
FT                                /FTId=PRO_0000281790.
FT   DOMAIN      168    283       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   CONFLICT    535    535       L -> P (in Ref. 2; AAH85544).
FT                                {ECO:0000305}.
SQ   SEQUENCE   808 AA;  90438 MW;  11510B288E3195B0 CRC64;
     MGESKNMVLN GRRHGRKFSS NQPVSKSRLQ NTQRSHLRQN KGSPSVRRCS RRCGGAPPEA
     ERRHVPSSGM TAKELCEYDD LSTSLILDPY LGFQTHKMNT RFRPIKGRQR ELREIIELFK
     KHDNLEKAFQ ALTSGDWTRH HFLNKTKSQE KLFKAHVFVY LRMFASDSGF EILSCNRYSS
     EQNGAKIVAT KDWKRNDKIE HLVGCIAELS PSEERMLLRH GENDFSVMYS TRKNCAQLWL
     GPAAFINHDC RPNCKFVSTG RDTACVKVLR DIEPGEEISC YYGDGFFGEN NEFCECYTCE
     RRGTGAFKSK PGLPVEAPVI NSKYGLRETD KRLNRLKKLG ESCRNSDSQS VSSNAEADSQ
     EPTTVQTSLR KRTSQSCVKK HGEAKAVTRQ TLSSTPSSTS SSKRSQANIS SLPKRLKSKP
     TQTLSKGRRR CRGLWTKGSS RVSASGNLKE SSRRDTDRRR SASKGSVARS SENNRSSSKG
     ASPCKDSTLC PYRTRRSTRT SLGAQGAEGT EASNHPASPS IVLKSEPGEF IPVTLGHQMS
     TPSLDSSCPK KGTCPRRRRT VKQEDSYGES FVQEGVPDLR HAVRAADVAD CGKVVLGLPD
     RHQHYNGSSK SSKALRRGKG KKKRQITRYD AQLILQNNSG IPKITLRRRR DSSSSKNEPR
     ETSSSSSSKI SIKFSKEHEK DRSSSYVAKL NNGFSHGPHS SSTKLKIQLK REEDPASLHR
     TYPEDVTLGI VQRDAADVLD HKAAAQVGQD MEVESMSSED DDDDYFDNED DFIPLPPAKR
     LRLIVGKDSI DIDISSRRRE DQSLRLNA
//
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