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Database: UniProt/SWISS-PROT
Entry: KMT5C_RAT
LinkDB: KMT5C_RAT
Original site: KMT5C_RAT 
ID   KMT5C_RAT               Reviewed;         470 AA.
AC   P0C2N6;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   07-NOV-2018, entry version 84.
DE   RecName: Full=Histone-lysine N-methyltransferase KMT5C {ECO:0000305};
DE            EC=2.1.1.43;
DE   AltName: Full=Lysine-specific methyltransferase 5C {ECO:0000312|RGD:1305226};
DE   AltName: Full=Suppressor of variegation 4-20 homolog 2;
DE            Short=Su(var)4-20 homolog 2;
DE            Short=Suv4-20h2;
GN   Name=Kmt5c {ECO:0000312|RGD:1305226}; Synonyms=Suv420h2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Soares M.B., Casavant T.L., Sheffield V.C., Bonaldo M.F., Bair T.B.,
RA   Scheetz T.E., Snir E., Akabogu I., Bair J.L., Berger B., Crouch K.,
RA   Davis A., Eystone M.E., Keppel C., Kucaba T.A., Lebeck M., Lin J.L.,
RA   de Melo A.I.R., Rehmann J., Reiter R.S., Schaefer K., Smith C.,
RA   Tack D., Trout K., Lin J.J.-C.;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   INDUCTION.
RX   PubMed=17182829;
RA   Pogribny I.P., Tryndyak V.P., Muskhelishvili L., Rusyn I., Ross S.A.;
RT   "Methyl deficiency, alterations in global histone modifications, and
RT   carcinogenesis.";
RL   J. Nutr. 137:216S-222S(2007).
RN   [3]
RP   INDUCTION.
RX   PubMed=16497704; DOI=10.1093/carcin/bgi364;
RA   Pogribny I.P., Ross S.A., Tryndyak V.P., Pogribna M., Poirier L.A.,
RA   Karpinets T.V.;
RT   "Histone H3 lysine 9 and H4 lysine 20 trimethylation and the
RT   expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in
RT   hepatocarcinogenesis induced by methyl deficiency in rats.";
RL   Carcinogenesis 27:1180-1186(2006).
CC   -!- FUNCTION: Histone methyltransferase that specifically
CC       trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation
CC       represents a specific tag for epigenetic transcriptional
CC       repression. Mainly functions in pericentric heterochromatin
CC       regions, thereby playing a central role in the establishment of
CC       constitutive heterochromatin in these regions. KMT5B is targeted
CC       to histone H3 via its interaction with RB1 family proteins (RB1,
CC       RBL1 and RBL2).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000255|PROSITE-ProRule:PRU00903}.
CC   -!- SUBUNIT: Interacts with HP1 proteins CBX1, CBX3 and CBX5.
CC       Interacts with RB1 family proteins RB1, RBL1 and RBL2.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Associated with
CC       pericentric heterochromatin. CBX1 and CBX5 are required for the
CC       localization to pericentric heterochromatin.
CC   -!- INDUCTION: Strongly down-regulated in various cancers such as
CC       hepatocarcinomas. {ECO:0000269|PubMed:16497704,
CC       ECO:0000269|PubMed:17182829}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00903}.
DR   EMBL; AY724526; -; NOT_ANNOTATED_CDS; mRNA.
DR   RefSeq; NP_001100945.1; NM_001107475.1.
DR   RefSeq; XP_006228321.1; XM_006228259.1.
DR   RefSeq; XP_006228322.1; XM_006228260.1.
DR   RefSeq; XP_006228323.1; XM_006228261.1.
DR   RefSeq; XP_006228325.1; XM_006228263.1.
DR   RefSeq; XP_006228326.1; XM_006228264.1.
DR   RefSeq; XP_006228327.1; XM_006228265.3.
DR   RefSeq; XP_006228328.1; XM_006228266.1.
DR   UniGene; Rn.105145; -.
DR   ProteinModelPortal; P0C2N6; -.
DR   SMR; P0C2N6; -.
DR   STRING; 10116.ENSRNOP00000023744; -.
DR   iPTMnet; P0C2N6; -.
DR   PhosphoSitePlus; P0C2N6; -.
DR   PaxDb; P0C2N6; -.
DR   PRIDE; P0C2N6; -.
DR   Ensembl; ENSRNOT00000023744; ENSRNOP00000023744; ENSRNOG00000017508.
DR   GeneID; 308345; -.
DR   KEGG; rno:308345; -.
DR   UCSC; RGD:1305226; rat.
DR   CTD; 84787; -.
DR   RGD; 1305226; Kmt5c.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00520000055640; -.
DR   HOVERGEN; HBG095676; -.
DR   InParanoid; P0C2N6; -.
DR   KO; K11429; -.
DR   OMA; PQQDWHW; -.
DR   OrthoDB; EOG091G0IUY; -.
DR   PhylomeDB; P0C2N6; -.
DR   TreeFam; TF106433; -.
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:P0C2N6; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000017508; Expressed in 10 organ(s), highest expression level in colon.
DR   Genevisible; P0C2N6; RN.
DR   GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Ensembl.
DR   GO; GO:0005720; C:nuclear heterochromatin; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005721; C:pericentric heterochromatin; IEA:Ensembl.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:Ensembl.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:Ensembl.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN         1    470       Histone-lysine N-methyltransferase KMT5C.
FT                                /FTId=PRO_0000281795.
FT   DOMAIN      104    218       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   REGION      350    443       Required for heterochromatin
FT                                localization. {ECO:0000250}.
SQ   SEQUENCE   470 AA;  53607 MW;  060148E2FFFB49AB CRC64;
     MGPDRVTARE LCENDDLATS LVLDPYLGFR THKMNVSPVP TLRRQHHLRS ALEAFLRQRD
     LEAAFRALTL GGWMAHYFQN RAPRQEAALK NHIFCYLRAF LPESGFTILP CTRYSMETNG
     AKIVSTRAWK KNEKLELLVG CIAELREEDE YLLRAGENDF SVMYSTRKRS AQLWLGPAAF
     INHDCKPNCK FVPSDGNTAC VKVLRDIEPG DEVTCFYGEG FFGEKNEHCE CYTCERKGEG
     AFRLQPREPE LRPRPLDKYE LRETKRRLQQ CLDSSQQNLL SLRACSHLSP LRPDPFCAAC
     QPSCLLPVSP HMDYLPLWLQ WVPQPQPRVR PRKRRRRRRR RPRIPQASLS PDLHTACVSL
     HRWGGCGPHC QLRAEAMVTL HLLPQTRWTP KQDWYWARRY GLPSVVRVEL SPLAPALPAA
     PAPAGNLGPT PTPDLIPKQA LAFAPFCPPK RLRLVVSHGS IDLDINSGEP
//
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