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Database: UniProt/SWISS-PROT
Entry: KT5AA_DANRE
LinkDB: KT5AA_DANRE
Original site: KT5AA_DANRE 
ID   KT5AA_DANRE             Reviewed;         344 AA.
AC   Q071E0; Q0P3X5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   23-MAY-2018, entry version 78.
DE   RecName: Full=N-lysine methyltransferase KMT5A-A {ECO:0000305};
DE            EC=2.1.1.-;
DE   AltName: Full=Histone-lysine N-methyltransferase KMT5A-A;
DE            EC=2.1.1.43;
DE   AltName: Full=Lysine-specific methylase 5A-A {ECO:0000250|UniProtKB:Q9NQR1};
DE   AltName: Full=SET domain-containing protein 8-A;
GN   Name=kmt5aa {ECO:0000250|UniProtKB:Q9NQR1};
GN   Synonyms=set8a, setd8, setd8a; ORFNames=zgc:153719;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y.,
RA   Sheng Y., Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I.,
RA   Kanki J.P., Liu T.X., Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protein-lysine N-methyltransferase that monomethylates
CC       both histones and non-histone proteins. Specifically
CC       monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is
CC       enriched during mitosis and represents a specific tag for
CC       epigenetic transcriptional repression. Mainly functions in
CC       euchromatin regions, thereby playing a central role in the
CC       silencing of euchromatic genes. Required for cell proliferation,
CC       probably by contributing to the maintenance of proper higher-order
CC       structure of DNA during mitosis. Involved in chromosome
CC       condensation and proper cytokinesis (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000255|PROSITE-ProRule:PRU00904}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}. Note=Specifically localizes to mitotic chromosomes.
CC       Associates with silent chromatin on euchromatic arms (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. PR/SET subfamily. {ECO:0000255|PROSITE-ProRule:PRU00904}.
DR   EMBL; DQ343297; ABC68593.1; -; mRNA.
DR   EMBL; BC122396; AAI22397.1; -; mRNA.
DR   RefSeq; NP_001038814.2; NM_001045349.2.
DR   UniGene; Dr.122337; -.
DR   UniGene; Dr.77877; -.
DR   ProteinModelPortal; Q071E0; -.
DR   SMR; Q071E0; -.
DR   BioGrid; 591485; 1.
DR   STRING; 7955.ENSDARP00000089529; -.
DR   PaxDb; Q071E0; -.
DR   PRIDE; Q071E0; -.
DR   GeneID; 751629; -.
DR   KEGG; dre:751629; -.
DR   CTD; 751629; -.
DR   ZFIN; ZDB-GENE-060825-37; kmt5aa.
DR   eggNOG; KOG1085; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000020818; -.
DR   InParanoid; Q071E0; -.
DR   KO; K11428; -.
DR   PhylomeDB; Q071E0; -.
DR   PRO; PR:Q071E0; -.
DR   Proteomes; UP000000437; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:ZFIN.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   InterPro; IPR016858; Hist_H4-K20_MeTrfase.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51571; SAM_MT43_PR_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromatin regulator; Chromosome;
KW   Complete proteome; Methyltransferase; Mitosis; Nucleus;
KW   Reference proteome; Repressor; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1    344       N-lysine methyltransferase KMT5A-A.
FT                                /FTId=PRO_0000316999.
FT   DOMAIN      208    329       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   REGION      218    220       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00904}.
FT   REGION      290    291       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00904}.
FT   BINDING     263    263       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00190,
FT                                ECO:0000255|PROSITE-ProRule:PRU00904}.
FT   CONFLICT     16     16       D -> E (in Ref. 2; AAI22397).
FT                                {ECO:0000305}.
FT   CONFLICT     89     89       V -> A (in Ref. 2; AAI22397).
FT                                {ECO:0000305}.
FT   CONFLICT    100    100       P -> R (in Ref. 2; AAI22397).
FT                                {ECO:0000305}.
FT   CONFLICT    145    145       S -> P (in Ref. 2; AAI22397).
FT                                {ECO:0000305}.
SQ   SEQUENCE   344 AA;  39155 MW;  93FE1D36C3AEF976 CRC64;
     MFPAVNEIKV QTWRRDQRGE CPRRSAQCRL FSCAHRECAP AARSLENRGP ENRTARPEAT
     MSGDVLCNGH SAFHRLLKHS SSRTHEALVV KIIQENKNTP LFCTAPEPRR DSGVNGEFLL
     NSAELQDEQT LPLHCIHSAA DITSSKHRKP ARRKVKRSTK RAAESKSPAN RKVTDYFPIR
     RSSRKSKSEL KYEEKQHIDT LISNGIEDGM MVRFIEGKGR GVFATQPFQK GQYVVEYHGD
     LLQITDAKQR EALYAQDPST GCYMYYFQYL SKTYCVDATK ESDRLGRLIN HSKNGNCQTK
     LHAIAGKPHL ILVASRDIQE GEELLYDYGD RSKSSIEAHP WLKH
//
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