ID LT4R1_BOVIN Reviewed; 349 AA.
AC Q3T181;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Leukotriene B4 receptor 1;
DE Short=LTB4-R 1;
DE Short=LTB4-R1;
GN Name=LTB4R;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for extracellular ATP > UTP and ADP. The activity of
CC this receptor is mediated by G proteins which activate a
CC phosphatidylinositol-calcium second messenger system. May be the
CC cardiac P2Y receptor involved in the regulation of cardiac muscle
CC contraction through modulation of L-type calcium currents. Is a
CC receptor for leukotriene B4, a potent chemoattractant involved in
CC inflammation and immune response (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- PTM: Phosphorylated by GRK6 upon leukotriene B4 binding; which promotes
CC desensitization. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; BC102075; AAI02076.1; -; mRNA.
DR RefSeq; NP_001029910.1; NM_001034738.1.
DR AlphaFoldDB; Q3T181; -.
DR SMR; Q3T181; -.
DR STRING; 9913.ENSBTAP00000036335; -.
DR GlyCosmos; Q3T181; 2 sites, No reported glycans.
DR PaxDb; 9913-ENSBTAP00000036335; -.
DR Ensembl; ENSBTAT00000036478.2; ENSBTAP00000036335.1; ENSBTAG00000010238.4.
DR GeneID; 613482; -.
DR KEGG; bta:613482; -.
DR CTD; 1241; -.
DR VEuPathDB; HostDB:ENSBTAG00000010238; -.
DR VGNC; VGNC:31069; LTB4R.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00950000182966; -.
DR HOGENOM; CLU_009579_8_0_1; -.
DR InParanoid; Q3T181; -.
DR OMA; QRMRTKR; -.
DR OrthoDB; 4266448at2759; -.
DR TreeFam; TF330976; -.
DR Reactome; R-BTA-391906; Leukotriene receptors.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Proteomes; UP000009136; Chromosome 10.
DR Bgee; ENSBTAG00000010238; Expressed in surface of tongue and 80 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0001632; F:leukotriene B4 receptor activity; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000826; Formyl_rcpt-rel.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR003981; Leukotriene_B4_rcpt.
DR InterPro; IPR003983; Leukotriene_B4_typ-1_rcpt.
DR PANTHER; PTHR24225; CHEMOTACTIC RECEPTOR; 1.
DR PANTHER; PTHR24225:SF62; G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01477; LTB1RECEPTOR.
DR PRINTS; PR01476; LTBRECEPTOR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Phosphoprotein; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..349
FT /note="Leukotriene B4 receptor 1"
FT /id="PRO_0000245315"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..113
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 114..138
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 160..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..349
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 311..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..328
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 2
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 349 AA; 37689 MW; F7B6B97DE6518191 CRC64;
MNTTSPAAPS SSGVSFISLL VIIVLSVALA VGLPGNSFVV WSILAKLRKR SVTALMVLHL
ALADLAVLLT APFFLYSVAQ GTWTFGLSSC RLFHYVCGVS MYASVLLIMT MSLDRSLAVA
LPFVSQKLRT KAVAWRVLAG IWVMSVLLAT PVLLYRTVHL GLNNRSLTCF LKYPSERHRA
FHLFFEVITG FLLPFLVVVA SYCDIGRRLR ARRFRRSRRT GRLVALIILA FAAFWLPYHV
VNLAEGFRAA AGKALGSGPV GRRLLLARHV LITLAFLSSS VNPLLYACAG GGLLRSAGVG
FIAKLLEGTG SETSSSRRKG TLAQTLRGTP ASPEPDPAES LTASTNPLE
//
