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Database: UniProt/SWISS-PROT
Entry: MGST2_BOVIN
LinkDB: MGST2_BOVIN
Original site: MGST2_BOVIN 
ID   MGST2_BOVIN             Reviewed;         146 AA.
AC   Q2KJG4;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   28-MAR-2018, entry version 87.
DE   RecName: Full=Microsomal glutathione S-transferase 2;
DE            Short=Microsomal GST-2;
DE            EC=2.5.1.18;
GN   Name=MGST2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the production of LTC4 from LTA4 and
CC       reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-
CC       dinitrobenzene with reduced glutathione (By similarity).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
CC       Microsome membrane {ECO:0000305}; Multi-pass membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MAPEG family. {ECO:0000305}.
DR   EMBL; BT025439; ABF57395.1; -; mRNA.
DR   EMBL; BC105356; AAI05357.1; -; mRNA.
DR   RefSeq; NP_001069850.1; NM_001076382.1.
DR   UniGene; Bt.21183; -.
DR   ProteinModelPortal; Q2KJG4; -.
DR   SMR; Q2KJG4; -.
DR   STRING; 9913.ENSBTAP00000029028; -.
DR   PaxDb; Q2KJG4; -.
DR   PRIDE; Q2KJG4; -.
DR   Ensembl; ENSBTAT00000029028; ENSBTAP00000029028; ENSBTAG00000021779.
DR   GeneID; 615552; -.
DR   KEGG; bta:615552; -.
DR   CTD; 4258; -.
DR   VGNC; VGNC:31452; MGST2.
DR   eggNOG; ENOG410IX5K; Eukaryota.
DR   eggNOG; ENOG41121Z4; LUCA.
DR   GeneTree; ENSGT00430000030964; -.
DR   HOGENOM; HOG000116372; -.
DR   HOVERGEN; HBG105513; -.
DR   InParanoid; Q2KJG4; -.
DR   KO; K00799; -.
DR   OMA; IFRAQQN; -.
DR   OrthoDB; EOG091G12NW; -.
DR   TreeFam; TF105328; -.
DR   Reactome; R-BTA-156590; Glutathione conjugation.
DR   Reactome; R-BTA-5423646; Aflatoxin activation and detoxification.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000021779; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0008047; F:enzyme activator activity; IEA:InterPro.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IBA:GO_Central.
DR   GO; GO:0004364; F:glutathione transferase activity; IBA:GO_Central.
DR   GO; GO:0004464; F:leukotriene-C4 synthase activity; IBA:GO_Central.
DR   GO; GO:0006750; P:glutathione biosynthetic process; IEA:Ensembl.
DR   GO; GO:0019370; P:leukotriene biosynthetic process; IBA:GO_Central.
DR   GO; GO:0046466; P:membrane lipid catabolic process; IEA:Ensembl.
DR   Gene3D; 1.20.120.550; -; 1.
DR   InterPro; IPR001446; 5_LipOase_AP.
DR   InterPro; IPR023352; MAPEG-like_dom_sf.
DR   InterPro; IPR001129; Membr-assoc_MAPEG.
DR   Pfam; PF01124; MAPEG; 1.
DR   PRINTS; PR00488; 5LPOXGNASEAP.
DR   SUPFAM; SSF161084; SSF161084; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Endoplasmic reticulum; Leukotriene biosynthesis;
KW   Membrane; Microsome; Reference proteome; Transferase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    146       Microsomal glutathione S-transferase 2.
FT                                /FTId=PRO_0000246087.
FT   TRANSMEM      6     26       Helical. {ECO:0000255}.
FT   TRANSMEM     59     79       Helical. {ECO:0000255}.
FT   TRANSMEM    111    131       Helical. {ECO:0000255}.
SQ   SEQUENCE   146 AA;  16483 MW;  24BCF4E5E9CE0393 CRC64;
     MAGNSILLAA LSVLSACQQS YFAMQVGKAR SKYKVTPPSV SGSPDFERIF RAQQNCVEFY
     PIFIITLWMA GWYFNQVFAT CLGLVYIYSR HQYFWGYAEA AKKRVTGFRL SLGVLALLTV
     LGAVGILNSF LDEYLDIDIA KKLRHF
//
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