ID MTRH_METVS Reviewed; 319 AA.
AC A6UQL3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
DE EC=2.1.1.86 {ECO:0000255|HAMAP-Rule:MF_01501};
DE AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit H {ECO:0000255|HAMAP-Rule:MF_01501};
GN Name=mtrH {ECO:0000255|HAMAP-Rule:MF_01501}; OrderedLocusNames=Mevan_0880;
OS Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148
OS / SB).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=406327;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Anderson I.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus vannielii SB.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a complex that catalyzes the formation of methyl-
CC coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-
CC tetrahydromethanopterin. This is an energy-conserving, sodium-ion
CC translocating step. MtrH catalyzes the transfer of the methyl group
CC from methyl-tetrahydromethanopterin to the corrinoid prosthetic group
CC of MtrA. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2
CC Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2
CC Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286,
CC ChEBI:CHEBI:58319; EC=2.1.1.86; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_01501};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); methyl-
CC coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step
CC 2/2. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC -!- SUBUNIT: The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD,
CC MtrE, MtrF, MtrG and MtrH. {ECO:0000255|HAMAP-Rule:MF_01501}.
CC -!- SIMILARITY: Belongs to the MtrH family. {ECO:0000255|HAMAP-
CC Rule:MF_01501}.
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DR EMBL; CP000742; ABR54785.1; -; Genomic_DNA.
DR RefSeq; WP_011972686.1; NC_009634.1.
DR AlphaFoldDB; A6UQL3; -.
DR SMR; A6UQL3; -.
DR STRING; 406327.Mevan_0880; -.
DR GeneID; 5326203; -.
DR KEGG; mvn:Mevan_0880; -.
DR eggNOG; arCOG04336; Archaea.
DR HOGENOM; CLU_048697_0_0_2; -.
DR OrthoDB; 18811at2157; -.
DR UniPathway; UPA00640; UER00698.
DR Proteomes; UP000001107; Chromosome.
DR GO; GO:0030269; F:tetrahydromethanopterin S-methyltransferase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.20.20.20; Dihydropteroate synthase-like; 1.
DR HAMAP; MF_01501; MtrH; 1.
DR InterPro; IPR011005; Dihydropteroate_synth-like_sf.
DR InterPro; IPR023467; MeTrfase_MtrH/MtxH.
DR InterPro; IPR028342; MtrH.
DR NCBIfam; TIGR01114; mtrH; 1.
DR Pfam; PF02007; MtrH; 1.
DR PIRSF; PIRSF500206; MtrH; 1.
DR PIRSF; PIRSF004960; MtrH_MtxH; 1.
DR SUPFAM; SSF51717; Dihydropteroate synthetase-like; 1.
PE 3: Inferred from homology;
KW Methanogenesis; Methyltransferase; One-carbon metabolism; Transferase.
FT CHAIN 1..319
FT /note="Tetrahydromethanopterin S-methyltransferase subunit
FT H"
FT /id="PRO_1000024473"
SQ SEQUENCE 319 AA; 34222 MW; 02CB3953DCCCF298 CRC64;
MFRFDKEQMV IDFAGAKFGG QPGEYPTALS GTIFYARHKI VEDAKKGIFD KKAAEALINK
QAEMQDITGN SALVQVFGGT EEALVNYIDF VSEVWEGPML LDSTSGKARM AAAKRATEAG
YAKQCIYNSI NVSIDEEEFQ SLAESDVEAS IVLCFDPMDP SVEGKLNVLN NGGKTKDVGM
LDLAEKAGIK YPLIDVAVTP MGAGAGNAVR ASFAVKAKLG LAVGSGIHNV PSAWDWLREF
RKGLREEGKE QIAKDVHHVC DIGANIVQTM ASGDFVLYGP IDNAELAFPA VAMTDMIIAE
TAKELGTTPA AVHPLNKLI
//
