ID OPN4_FELCA Reviewed; 487 AA.
AC Q5YKK9;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Melanopsin;
DE AltName: Full=Opsin-4;
GN Name=OPN4;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=15842746; DOI=10.1017/s0952523805001069;
RA Semo M., Munoz Llamosas M., Foster R.G., Jeffery G.;
RT "Melanopsin (Opn4) positive cells in the cat retina are randomly
RT distributed across the ganglion cell layer.";
RL Vis. Neurosci. 22:111-116(2005).
CC -!- FUNCTION: Photoreceptor that binds cis-retinaldehydes (By similarity).
CC Contributes to pupillar reflex, photoentrainment and other non-image
CC forming responses to light (By similarity). May be involved in the
CC optokinetic visual tracking response (By similarity). May be involved
CC in the regulation of retinal hyaloid vessel growth and regression (By
CC similarity). {ECO:0000250|UniProtKB:Q9QXZ9}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9QXZ9};
CC Multi-pass membrane protein {ECO:0000255}. Cell projection, axon
CC {ECO:0000250|UniProtKB:Q9QXZ9}. Cell projection, dendrite
CC {ECO:0000250|UniProtKB:Q9QXZ9}. Perikaryon
CC {ECO:0000250|UniProtKB:Q9QXZ9}.
CC -!- TISSUE SPECIFICITY: Eye. Expression is restricted within the ganglion
CC cell layer. {ECO:0000269|PubMed:15842746}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY382594; AAR36861.1; -; mRNA.
DR RefSeq; NP_001009325.1; NM_001009325.2.
DR AlphaFoldDB; Q5YKK9; -.
DR SMR; Q5YKK9; -.
DR STRING; 9685.ENSFCAP00000051489; -.
DR PaxDb; 9685-ENSFCAP00000013930; -.
DR Ensembl; ENSFCAT00000057256.2; ENSFCAP00000051489.2; ENSFCAG00000015018.6.
DR GeneID; 493921; -.
DR KEGG; fca:493921; -.
DR VGNC; VGNC:103737; OPN4.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01100000263502; -.
DR HOGENOM; CLU_009579_3_12_1; -.
DR InParanoid; Q5YKK9; -.
DR OrthoDB; 3432893at2759; -.
DR Proteomes; UP000011712; Chromosome D2.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; TAS:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:1990913; C:sperm head plasma membrane; IEA:Ensembl.
DR GO; GO:0005502; F:11-cis retinal binding; ISS:UniProtKB.
DR GO; GO:0008020; F:G protein-coupled photoreceptor activity; ISS:UniProtKB.
DR GO; GO:0071482; P:cellular response to light stimulus; IBA:GO_Central.
DR GO; GO:0050960; P:detection of temperature stimulus involved in thermoception; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1990384; P:hyaloid vascular plexus regression; ISS:UniProtKB.
DR GO; GO:0007634; P:optokinetic behavior; ISS:UniProtKB.
DR GO; GO:0007602; P:phototransduction; ISS:UniProtKB.
DR GO; GO:0042752; P:regulation of circadian rhythm; ISS:UniProtKB.
DR GO; GO:0060041; P:retina development in camera-type eye; IEA:Ensembl.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR GO; GO:0043052; P:thermotaxis; IEA:Ensembl.
DR GO; GO:0007601; P:visual perception; IEA:InterPro.
DR CDD; cd15336; 7tmA_Melanopsin; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001760; Opsin.
DR InterPro; IPR027430; Retinal_BS.
DR PANTHER; PTHR24240:SF72; MELANOPSIN; 1.
DR PANTHER; PTHR24240; OPSIN; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00238; OPSIN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS00238; OPSIN; 1.
PE 2: Evidence at transcript level;
KW Biological rhythms; Cell membrane; Cell projection; Chromophore;
KW Disulfide bond; G-protein coupled receptor; Membrane;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..487
FT /note="Melanopsin"
FT /id="PRO_0000226728"
FT TOPO_DOM 1..67
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..139
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..183
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..291
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 313..327
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..487
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 436..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 335
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT DISULFID 138..216
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 487 AA; 53681 MW; B867E24B4D322D57 CRC64;
MNPPSGPRTQ EPSCVATPAS PSRWDGYRSS TSSLDQPLPI SPTAARAQAA AWIPFPTVDV
PDHAHYTLGT VILLVGLTGI LGNLMVIYTF CRSRGLRTPA NMFIINLAVS DFFMSFTQAP
VFFASSLHKR WLFGEAGCEF YAFCGALFGI TSMITLMAIA LDRYLVITHP LATIGVVSKR
RAALVLLGVW LYALAWSLPP FFGWSAYVPE GLLTSCSWDY MSFTPSVRAY TMLLFCFVFF
LPLLVIVYCY IFIFRAIRET GQALQTFRAC EGGGRSPRQR QRLQREWKMA KIELLVILLF
VLSWAPYSIV ALMAFAGYAH VLTPYMNSVP AVIAKASAIH NPIIYAITHP KYRMAIAQHL
PCLGVLLGVS GQHTGPYASY RSTHRSTLSS QASDLSWISG RRRQASLGSE SEVGWMDTEA
AAVWGAAQQV SGRFPCSQGL EDREAKAPVR PQGREAETPG QAMTMAMAPW DTPANCELPL
HPGWAFH
//
