ID PD2R_HUMAN Reviewed; 359 AA.
AC Q13258; G3V5L3; Q13250; Q13251; Q1ZZ52;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 27-MAR-2024, entry version 194.
DE RecName: Full=Prostaglandin D2 receptor;
DE Short=PGD receptor;
DE Short=PGD2 receptor;
DE AltName: Full=Prostanoid DP receptor;
GN Name=PTGDR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
RX PubMed=7642548; DOI=10.1074/jbc.270.32.18910;
RA Boie Y., Sawyer N., Slipetz D.M., Metters K.M., Abramovitz M.;
RT "Molecular cloning and characterization of the human prostanoid DP
RT receptor.";
RL J. Biol. Chem. 270:18910-18916(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Small intestine;
RA Martin A.L., Kaighin V.A., Aronstam R.S.;
RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-7; GLU-198; ALA-301 AND
RP GLN-332.
RG SeattleSNPs variation discovery resource;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP TISSUE SPECIFICITY.
RX PubMed=6302737; DOI=10.1016/0090-6980(83)90131-4;
RA Town M.H., Casals-Stenzel J., Schillinger E.;
RT "Pharmacological and cardiovascular properties of a hydantoin derivative,
RT BW 245 C, with high affinity and selectivity for PGD2 receptors.";
RL Prostaglandins 25:13-28(1983).
RN [8]
RP TISSUE SPECIFICITY.
RX PubMed=11082108; DOI=10.1038/sj.bjp.0703686;
RA Sharif N.A., Williams G.W., Davis T.L.;
RT "Pharmacology and autoradiography of human DP prostanoid receptors using
RT [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand.";
RL Br. J. Pharmacol. 131:1025-1038(2000).
RN [9]
RP INVOLVEMENT IN SUSCEPTIBILITY TO ASRT1.
RX PubMed=15496624; DOI=10.1056/nejmoa031785;
RA Oguma T., Palmer L.J., Birben E., Sonna L.A., Asano K., Lilly C.M.;
RT "Role of prostanoid DP receptor variants in susceptibility to asthma.";
RL N. Engl. J. Med. 351:1752-1763(2004).
CC -!- FUNCTION: Receptor for prostaglandin D2 (PGD2). The activity of this
CC receptor is mainly mediated by G(s) proteins that stimulate adenylate
CC cyclase, resulting in an elevation of intracellular cAMP. A
CC mobilization of calcium is also observed, but without formation of
CC inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-
CC dependent maturation of mast cells. PLA2G3 is secreted by immature mast
CC cells and acts on nearby fibroblasts upstream to PTDGS to synthesize
CC PGD2, which in turn promotes mast cell maturation and degranulation via
CC PTGDR (By similarity). {ECO:0000250|UniProtKB:P70263,
CC ECO:0000250|UniProtKB:Q9R261}.
CC -!- INTERACTION:
CC Q13258; Q9NZ52: GGA3; NbExp=5; IntAct=EBI-20731195, EBI-447404;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q13258-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13258-2; Sequence=VSP_055141, VSP_055142;
CC -!- TISSUE SPECIFICITY: Expressed in retinal choroid, ciliary epithelium,
CC longitudinal and circular ciliary muscles, iris, small intestine and
CC platelet membranes. {ECO:0000269|PubMed:11082108,
CC ECO:0000269|PubMed:6302737}.
CC -!- DISEASE: Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related
CC traits include clinical symptoms of asthma, such as coughing, wheezing,
CC dyspnea, bronchial hyperresponsiveness as assessed by methacholine
CC challenge test, serum IgE levels, atopy and atopic dermatitis.
CC {ECO:0000269|PubMed:15496624}. Note=Disease susceptibility is
CC associated with variants affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=SeattleSNPs;
CC URL="http://pga.gs.washington.edu/data/apobec3f/";
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DR EMBL; U31098; AAC50176.1; -; Genomic_DNA.
DR EMBL; U31099; AAC50177.1; -; mRNA.
DR EMBL; U31332; AAC50178.1; -; Genomic_DNA.
DR EMBL; EF577397; ABQ52417.1; -; mRNA.
DR EMBL; DQ418808; ABD72608.1; -; Genomic_DNA.
DR EMBL; AL365475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471078; EAW65657.1; -; Genomic_DNA.
DR EMBL; BC040968; AAH40968.1; -; mRNA.
DR CCDS; CCDS61454.1; -. [Q13258-2]
DR CCDS; CCDS9707.1; -. [Q13258-1]
DR PIR; I39153; I39153.
DR RefSeq; NP_000944.1; NM_000953.2. [Q13258-1]
DR RefSeq; NP_001268398.1; NM_001281469.1. [Q13258-2]
DR RefSeq; XP_005267948.1; XM_005267891.3. [Q13258-1]
DR AlphaFoldDB; Q13258; -.
DR SMR; Q13258; -.
DR BioGRID; 111701; 10.
DR IntAct; Q13258; 5.
DR MINT; Q13258; -.
DR STRING; 9606.ENSP00000303424; -.
DR BindingDB; Q13258; -.
DR ChEMBL; CHEMBL4427; -.
DR DrugBank; DB00716; Nedocromil.
DR DrugBank; DB00374; Treprostinil.
DR DrugCentral; Q13258; -.
DR GuidetoPHARMACOLOGY; 338; -.
DR SwissLipids; SLP:000001561; -.
DR GlyCosmos; Q13258; 3 sites, No reported glycans.
DR GlyGen; Q13258; 3 sites.
DR iPTMnet; Q13258; -.
DR PhosphoSitePlus; Q13258; -.
DR BioMuta; PTGDR; -.
DR DMDM; 2495009; -.
DR EPD; Q13258; -.
DR MassIVE; Q13258; -.
DR PaxDb; 9606-ENSP00000303424; -.
DR PeptideAtlas; Q13258; -.
DR ProteomicsDB; 59257; -. [Q13258-1]
DR Antibodypedia; 10764; 233 antibodies from 28 providers.
DR DNASU; 5729; -.
DR Ensembl; ENST00000306051.3; ENSP00000303424.2; ENSG00000168229.4. [Q13258-1]
DR Ensembl; ENST00000553372.1; ENSP00000452408.1; ENSG00000168229.4. [Q13258-2]
DR GeneID; 5729; -.
DR KEGG; hsa:5729; -.
DR MANE-Select; ENST00000306051.3; ENSP00000303424.2; NM_000953.3; NP_000944.1.
DR UCSC; uc001wzq.3; human. [Q13258-1]
DR AGR; HGNC:9591; -.
DR CTD; 5729; -.
DR DisGeNET; 5729; -.
DR GeneCards; PTGDR; -.
DR HGNC; HGNC:9591; PTGDR.
DR HPA; ENSG00000168229; Tissue enhanced (intestine, lymphoid tissue).
DR MalaCards; PTGDR; -.
DR MIM; 604687; gene.
DR MIM; 607277; phenotype.
DR neXtProt; NX_Q13258; -.
DR OpenTargets; ENSG00000168229; -.
DR PharmGKB; PA285; -.
DR VEuPathDB; HostDB:ENSG00000168229; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244902; -.
DR HOGENOM; CLU_045991_0_2_1; -.
DR InParanoid; Q13258; -.
DR OMA; NWHSNSC; -.
DR OrthoDB; 5355693at2759; -.
DR PhylomeDB; Q13258; -.
DR TreeFam; TF324982; -.
DR PathwayCommons; Q13258; -.
DR Reactome; R-HSA-391908; Prostanoid ligand receptors.
DR Reactome; R-HSA-418555; G alpha (s) signalling events.
DR SignaLink; Q13258; -.
DR SIGNOR; Q13258; -.
DR BioGRID-ORCS; 5729; 21 hits in 1152 CRISPR screens.
DR ChiTaRS; PTGDR; human.
DR GeneWiki; Prostaglandin_D2_receptor; -.
DR GenomeRNAi; 5729; -.
DR Pharos; Q13258; Tclin.
DR PRO; PR:Q13258; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q13258; Protein.
DR Bgee; ENSG00000168229; Expressed in granulocyte and 108 other cell types or tissues.
DR Genevisible; Q13258; HS.
DR GO; GO:0016020; C:membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:BHF-UCL.
DR GO; GO:0004956; F:prostaglandin D receptor activity; IBA:GO_Central.
DR GO; GO:0001785; F:prostaglandin J receptor activity; IEA:Ensembl.
DR GO; GO:0046085; P:adenosine metabolic process; IEA:Ensembl.
DR GO; GO:0071799; P:cellular response to prostaglandin D stimulus; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; NAS:UniProtKB.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0030238; P:male sex determination; IEA:Ensembl.
DR GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0030431; P:sleep; IEA:Ensembl.
DR CDD; cd15140; 7tmA_PGD2; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000376; Pglndn_D_rcpt.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR PANTHER; PTHR11866; G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBER; 1.
DR PANTHER; PTHR11866:SF14; PROSTAGLANDIN D2 RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00854; PRSTNOIDDPR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Asthma; Cell membrane; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Mast cell degranulation;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..359
FT /note="Prostaglandin D2 receptor"
FT /id="PRO_0000070047"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..107
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..262
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..310
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 311..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 297
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VAR_SEQ 283..296
FT /note="YRAYYGAFKDVKEK -> AFVPGVPAKTPGSR (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055141"
FT VAR_SEQ 297..359
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_055142"
FT VARIANT 7
FT /note="R -> C (in dbSNP:rs41311442)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_033482"
FT VARIANT 198
FT /note="G -> E (in dbSNP:rs41312444)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_054975"
FT VARIANT 301
FT /note="E -> A (in dbSNP:rs41312504)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_033483"
FT VARIANT 332
FT /note="R -> Q (in dbSNP:rs41312506)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_054976"
SQ SEQUENCE 359 AA; 40271 MW; 098F89F08D0BE12A CRC64;
MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV
FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST
LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG
TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT
RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS
EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL
//
