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Database: UniProt/SWISS-PROT
Entry: PORA_THEMA
LinkDB: PORA_THEMA
Original site: PORA_THEMA 
ID   PORA_THEMA              Reviewed;         392 AA.
AC   O05651;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 2.
DT   05-DEC-2018, entry version 114.
DE   RecName: Full=Pyruvate synthase subunit PorA;
DE            EC=1.2.7.1;
DE   AltName: Full=Pyruvate oxidoreductase alpha chain;
DE            Short=POR;
DE   AltName: Full=Pyruvic-ferredoxin oxidoreductase subunit alpha;
GN   Name=porA; OrderedLocusNames=TM_0017;
OS   Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099).
OC   Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga.
OX   NCBI_TaxID=243274;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 1-43.
RC   STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
RX   PubMed=8550425; DOI=10.1128/jb.178.1.248-257.1996;
RA   Kletzin A., Adams M.W.W.;
RT   "Molecular and phylogenetic characterization of pyruvate and 2-
RT   ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus
RT   and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.";
RL   J. Bacteriol. 178:248-257(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
RX   PubMed=10360571; DOI=10.1038/20601;
RA   Nelson K.E., Clayton R.A., Gill S.R., Gwinn M.L., Dodson R.J.,
RA   Haft D.H., Hickey E.K., Peterson J.D., Nelson W.C., Ketchum K.A.,
RA   McDonald L.A., Utterback T.R., Malek J.A., Linher K.D., Garrett M.M.,
RA   Stewart A.M., Cotton M.D., Pratt M.S., Phillips C.A., Richardson D.L.,
RA   Heidelberg J.F., Sutton G.G., Fleischmann R.D., Eisen J.A., White O.,
RA   Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.;
RT   "Evidence for lateral gene transfer between Archaea and Bacteria from
RT   genome sequence of Thermotoga maritima.";
RL   Nature 399:323-329(1999).
RN   [3]
RP   PROTEIN SEQUENCE OF 1-43, AND CHARACTERIZATION.
RC   STRAIN=ATCC 43589 / MSB8 / DSM 3109 / JCM 10099;
RX   PubMed=8305426; DOI=10.1021/bi00170a019;
RA   Blamey J.M., Adams M.W.W.;
RT   "Characterization of an ancestral type of pyruvate ferredoxin
RT   oxidoreductase from the hyperthermophilic bacterium, Thermotoga
RT   maritima.";
RL   Biochemistry 33:1000-1007(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate =
CC         acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin];
CC         Xref=Rhea:RHEA:12765, Rhea:RHEA-COMP:10000, Rhea:RHEA-
CC         COMP:10001, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1;
CC   -!- SUBUNIT: Heterotetramer of one alpha, one beta, one delta and one
CC       gamma chain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD35111.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAA59457.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; X85171; CAA59457.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE000512; AAD35111.1; ALT_INIT; Genomic_DNA.
DR   PIR; D59427; C72427.
DR   RefSeq; NP_227833.1; NC_000853.1.
DR   ProteinModelPortal; O05651; -.
DR   SMR; O05651; -.
DR   STRING; 243274.TM0017; -.
DR   EnsemblBacteria; AAD35111; AAD35111; TM_0017.
DR   GeneID; 896831; -.
DR   KEGG; tma:TM0017; -.
DR   PATRIC; fig|243274.5.peg.15; -.
DR   eggNOG; ENOG4105D95; Bacteria.
DR   eggNOG; COG0674; LUCA.
DR   InParanoid; O05651; -.
DR   KO; K00169; -.
DR   OMA; WNDQQDS; -.
DR   BioCyc; MetaCyc:MONOMER-423; -.
DR   Proteomes; UP000008183; Chromosome.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   Gene3D; 3.40.50.920; -; 1.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF52518; SSF52518; 1.
DR   SUPFAM; SSF52922; SSF52922; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Direct protein sequencing; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN         1    392       Pyruvate synthase subunit PorA.
FT                                /FTId=PRO_0000099902.
FT   COMPBIAS     72     79       Poly-Ala.
SQ   SEQUENCE   392 AA;  44112 MW;  ACEF0E34C9EC1818 CRC64;
     MERVVERVAV TGAEAVANAM RQIEPDVVAA YPITPQTPIV EYFARFVADG VVRTEMIPVE
     SEHSAMSAVV GAAAAGARAM TATSANGLAL MHEIVYIAAS YRLPIVMPVV NRALSGPINI
     HCDHSDAMAE RDSGWIQLFA ETNQEAYDFT ILAVRLAEHE DVRLPVMVNL DGFILSHGVE
     PVEFYPDELV KKFVGELKPM YPLLDTEHPV TWGPLDLYDY YFEHKRQQIE AMENVKKVFP
     EIAKEFEETF GRKYWFVEPY RMEDAEHVMV ALGSTNSTIK YVVDELREEG YKVGSLKIWM
     FRPFPKEQLQ ELLNGRKSVV VLDRAVSFGA EAPLYEAVKS ALYEVAARPM LGSYVYGLGG
     RDIKPEHIRK AFEDAINGNL IADEQRYLGL RE
//
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