ID RHG19_CHICK Reviewed; 495 AA.
AC Q5F3G0;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=Rho GTPase-activating protein 19;
DE AltName: Full=Rho-type GTPase-activating protein 19;
GN Name=ARHGAP19; ORFNames=RCJMB04_18c11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: GTPase activator for the Rho-type GTPases by converting them
CC to an inactive GDP-bound state. {ECO:0000250}.
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DR EMBL; AJ851690; CAH65324.1; -; mRNA.
DR RefSeq; NP_001012927.1; NM_001012909.1.
DR AlphaFoldDB; Q5F3G0; -.
DR SMR; Q5F3G0; -.
DR STRING; 9031.ENSGALP00000054557; -.
DR PaxDb; 9031-ENSGALP00000032595; -.
DR GeneID; 423846; -.
DR KEGG; gga:423846; -.
DR CTD; 84986; -.
DR VEuPathDB; HostDB:geneid_423846; -.
DR eggNOG; KOG1453; Eukaryota.
DR InParanoid; Q5F3G0; -.
DR PhylomeDB; Q5F3G0; -.
DR PRO; PR:Q5F3G0; -.
DR Proteomes; UP000000539; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04392; RhoGAP_ARHGAP19; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047941; ARHGAP19_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR14963; RHO GTPASE ACTIVATING PROTEIN 18,19-RELATED; 1.
DR PANTHER; PTHR14963:SF7; RHO GTPASE-ACTIVATING PROTEIN 19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW GTPase activation; Reference proteome.
FT CHAIN 1..495
FT /note="Rho GTPase-activating protein 19"
FT /id="PRO_0000280467"
FT DOMAIN 98..304
FT /note="Rho-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00172"
FT REGION 327..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 470..488
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 55450 MW; 4EC47B445159078E CRC64;
MAAGAPAAGA RRGGSEAICN LVICNDSSLR SQPIIFNPDF FVEKLRHEKP EVFTELVVSN
ITRLIDLPGA ELAQLMGEED PKLPGANSTA SGFFRSLMSL KRKEKGVVFG SPLTEEGIAQ
VSQLIEYLHK NLRAEGLFRV PGNSIRQQIL KDALNSGTDI DLDSGEFHSN DVATLLKMFL
GELPEPLLTH KHFHAHLKIA DLTLFDEKGN KTSTPDKERQ IEALQLLFLI LPAPNRSLLK
LLLDLLYQTA KKQDKNKMSA HNLALMFAPH ILWPRNVTAN DLQENITKLN NGVTFMIKHS
QKLFKAPAYI RECARLHYLG SRAHTSKDDL DLLTSPGSKE LQPLKSQKRS RLDSCHQEET
QQRTEEALRE LFRHVHNMPD SAKKKKLIRQ FNKHPSALTP SSDVATPPAP RRARSRSFSG
LIKRKVLGTP VIQERKSRDS TPEPKRVSKE NVHLLQKCGS PAHMSQGKLK SLEGQKEESC
RRMRAHLLSK DSSSL
//
