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Database: UniProt/SWISS-PROT
Entry: SDHB_DANRE
LinkDB: SDHB_DANRE
Original site: SDHB_DANRE 
ID   SDHB_DANRE              Reviewed;         280 AA.
AC   A5PL98;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   16-JAN-2019, entry version 79.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;
DE            EC=1.3.5.1;
DE   AltName: Full=Iron-sulfur subunit of complex II;
DE            Short=Ip;
DE   Flags: Precursor;
GN   Name=sdhb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate
CC       dehydrogenase (SDH) that is involved in complex II of the
CC       mitochondrial electron transport chain and is responsible for
CC       transferring electrons from succinate to ubiquinone (coenzyme Q).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + succinate = a quinol + fumarate;
CC         Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1;
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       fumarate from succinate (eukaryal route): step 1/1.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: the
CC       flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a
CC       cytochrome b composed of sdhc and sdhd. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC       reductase iron-sulfur protein family. {ECO:0000305}.
DR   EMBL; BC142799; AAI42800.1; -; mRNA.
DR   RefSeq; NP_001092210.1; NM_001098740.1.
DR   UniGene; Dr.75182; -.
DR   ProteinModelPortal; A5PL98; -.
DR   SMR; A5PL98; -.
DR   STRING; 7955.ENSDARP00000062263; -.
DR   PaxDb; A5PL98; -.
DR   PeptideAtlas; A5PL98; -.
DR   PRIDE; A5PL98; -.
DR   Ensembl; ENSDART00000062264; ENSDARP00000062263; ENSDARG00000075768.
DR   GeneID; 562149; -.
DR   KEGG; dre:562149; -.
DR   CTD; 6390; -.
DR   ZFIN; ZDB-GENE-030131-8005; sdhb.
DR   eggNOG; KOG3049; Eukaryota.
DR   eggNOG; COG0479; LUCA.
DR   GeneTree; ENSGT00390000013558; -.
DR   HOGENOM; HOG000160590; -.
DR   HOVERGEN; HBG005483; -.
DR   InParanoid; A5PL98; -.
DR   KO; K00235; -.
DR   OMA; DGQYFGP; -.
DR   OrthoDB; 1264157at2759; -.
DR   PhylomeDB; A5PL98; -.
DR   TreeFam; TF300754; -.
DR   Reactome; R-DRE-71403; Citric acid cycle (TCA cycle).
DR   UniPathway; UPA00223; UER01006.
DR   PRO; PR:A5PL98; -.
DR   Proteomes; UP000000437; Chromosome 22.
DR   Bgee; ENSDARG00000075768; Expressed in 34 organ(s), highest expression level in muscle tissue.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; ISS:UniProtKB.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; ISS:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; ISS:UniProtKB.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0022904; P:respiratory electron transport chain; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S.
DR   InterPro; IPR025192; Succ_DH/fum_Rdtase_N.
DR   Pfam; PF13085; Fer2_3; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   TIGRFAMs; TIGR00384; dhsB; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   2: Evidence at transcript level;
KW   2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron;
KW   Iron-sulfur; Membrane; Metal-binding; Mitochondrion;
KW   Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW   Transit peptide; Transport; Tricarboxylic acid cycle.
FT   TRANSIT       1     25       Mitochondrion. {ECO:0000250}.
FT   CHAIN        26    280       Succinate dehydrogenase [ubiquinone]
FT                                iron-sulfur subunit, mitochondrial.
FT                                /FTId=PRO_0000343801.
FT   DOMAIN       39    129       2Fe-2S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00465}.
FT   DOMAIN      175    205       4Fe-4S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL        92     92       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL        97     97       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL       100    100       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL       112    112       Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT   METAL       185    185       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       188    188       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       191    191       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       195    195       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       242    242       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       248    248       Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT   METAL       252    252       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   BINDING     200    200       Ubiquinone; shared with dhsd.
FT                                {ECO:0000250}.
SQ   SEQUENCE   280 AA;  31740 MW;  A16A68A72849B844 CRC64;
     MAAVCFSLSR CCSAVHRPAV TAVRFAQTAA APAAQPRIKK FQIYRWDPDT VGDKPRMQTY
     EIDLNTCGPM VLDALIKIKN EMDSTLTFRR SCREGICGSC AMNINGGNTL ACLNKIDTNT
     SKVTKIYPLP HMYVVKDLVP DMSNFYAQYK SIEPYLKKKD ESQQGKQQYL QSVEDRQKLD
     GLYECILCAC CSTSCPSYWW NADKYLGPAV LMQAYRWMID SRDDFTEDRL SKLQDPFSLY
     RCHTIMNCTR TCPKGLNPGK AIAEIKKMMV TYKQKDAVAA
//
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