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Database: UniProt/SWISS-PROT
Entry: SDHB_PIG
LinkDB: SDHB_PIG
Original site: SDHB_PIG 
ID   SDHB_PIG                Reviewed;         280 AA.
AC   Q007T0; Q0QEX6;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   13-FEB-2019, entry version 76.
DE   RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;
DE            EC=1.3.5.1;
DE   AltName: Full=Iron-sulfur subunit of complex II;
DE            Short=Ip;
DE   Flags: Precursor;
GN   Name=SDHB;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Liu G.Y.;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 13-264.
RC   TISSUE=Liver;
RX   PubMed=16751257; DOI=10.1093/molbev/msl027;
RA   Kullberg M., Nilsson M.A., Arnason U., Harley E.H., Janke A.;
RT   "Housekeeping genes for phylogenetic analysis of eutherian
RT   relationships.";
RL   Mol. Biol. Evol. 23:1493-1503(2006).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 29-279 IN COMPLEX WITH
RP   IRON-SULFUR CLUSTERS AND UBIQUINONE, AND SUBUNIT.
RX   PubMed=15989954; DOI=10.1016/j.cell.2005.05.025;
RA   Sun F., Huo X., Zhai Y., Wang A., Xu J., Su D., Bartlam M., Rao Z.;
RT   "Crystal structure of mitochondrial respiratory membrane protein
RT   complex II.";
RL   Cell 121:1043-1057(2005).
CC   -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate
CC       dehydrogenase (SDH) that is involved in complex II of the
CC       mitochondrial electron transport chain and is responsible for
CC       transferring electrons from succinate to ubiquinone (coenzyme Q).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a quinone + succinate = a quinol + fumarate;
CC         Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1;
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC       Note=Binds 1 [2Fe-2S] cluster.;
CC   -!- COFACTOR:
CC       Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC       Note=Binds 1 [3Fe-4S] cluster.;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       fumarate from succinate (eukaryal route): step 1/1.
CC   -!- SUBUNIT: Component of complex II composed of four subunits: the
CC       flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a
CC       cytochrome b560 composed of SDHC and SDHD (PubMed:15989954).
CC       Interacts with SDHAF1; the interaction is required for iron-sulfur
CC       cluster incorporation into SDHB (By similarity).
CC       {ECO:0000250|UniProtKB:P21912, ECO:0000269|PubMed:15989954}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Matrix side
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC       reductase iron-sulfur protein family. {ECO:0000305}.
DR   EMBL; DQ915498; ABJ09403.1; -; mRNA.
DR   EMBL; DQ403018; ABD77151.1; -; mRNA.
DR   RefSeq; NP_001098423.1; NM_001104953.1.
DR   UniGene; Ssc.55804; -.
DR   PDB; 1ZOY; X-ray; 2.40 A; B=29-279.
DR   PDB; 1ZP0; X-ray; 3.50 A; B=29-279.
DR   PDB; 3ABV; X-ray; 3.24 A; B=29-280.
DR   PDB; 3AE1; X-ray; 3.14 A; B=29-280.
DR   PDB; 3AE2; X-ray; 3.10 A; B=29-280.
DR   PDB; 3AE3; X-ray; 3.35 A; B=29-280.
DR   PDB; 3AE4; X-ray; 2.91 A; B=29-280.
DR   PDB; 3AE5; X-ray; 3.41 A; B=29-280.
DR   PDB; 3AE6; X-ray; 3.40 A; B=29-280.
DR   PDB; 3AE7; X-ray; 3.62 A; B=29-280.
DR   PDB; 3AE8; X-ray; 3.40 A; B=29-280.
DR   PDB; 3AE9; X-ray; 3.31 A; B=29-280.
DR   PDB; 3AEA; X-ray; 3.39 A; B=29-280.
DR   PDB; 3AEB; X-ray; 3.00 A; B=29-280.
DR   PDB; 3AEC; X-ray; 3.61 A; B=29-280.
DR   PDB; 3AED; X-ray; 3.52 A; B=29-280.
DR   PDB; 3AEE; X-ray; 3.22 A; B=29-280.
DR   PDB; 3AEF; X-ray; 2.80 A; B=29-280.
DR   PDB; 3AEG; X-ray; 3.27 A; B=29-280.
DR   PDB; 3SFD; X-ray; 2.61 A; B=29-280.
DR   PDB; 3SFE; X-ray; 2.81 A; B=29-280.
DR   PDB; 4YTP; X-ray; 3.10 A; B=1-280.
DR   PDB; 4YXD; X-ray; 3.00 A; B=1-280.
DR   PDBsum; 1ZOY; -.
DR   PDBsum; 1ZP0; -.
DR   PDBsum; 3ABV; -.
DR   PDBsum; 3AE1; -.
DR   PDBsum; 3AE2; -.
DR   PDBsum; 3AE3; -.
DR   PDBsum; 3AE4; -.
DR   PDBsum; 3AE5; -.
DR   PDBsum; 3AE6; -.
DR   PDBsum; 3AE7; -.
DR   PDBsum; 3AE8; -.
DR   PDBsum; 3AE9; -.
DR   PDBsum; 3AEA; -.
DR   PDBsum; 3AEB; -.
DR   PDBsum; 3AEC; -.
DR   PDBsum; 3AED; -.
DR   PDBsum; 3AEE; -.
DR   PDBsum; 3AEF; -.
DR   PDBsum; 3AEG; -.
DR   PDBsum; 3SFD; -.
DR   PDBsum; 3SFE; -.
DR   PDBsum; 4YTP; -.
DR   PDBsum; 4YXD; -.
DR   ProteinModelPortal; Q007T0; -.
DR   SMR; Q007T0; -.
DR   STRING; 9823.ENSSSCP00000022052; -.
DR   ChEMBL; CHEMBL2366485; -.
DR   PaxDb; Q007T0; -.
DR   PeptideAtlas; Q007T0; -.
DR   PRIDE; Q007T0; -.
DR   GeneID; 414412; -.
DR   KEGG; ssc:414412; -.
DR   CTD; 6390; -.
DR   eggNOG; KOG3049; Eukaryota.
DR   eggNOG; COG0479; LUCA.
DR   HOVERGEN; HBG005483; -.
DR   InParanoid; Q007T0; -.
DR   KO; K00235; -.
DR   OrthoDB; 1264157at2759; -.
DR   UniPathway; UPA00223; UER01006.
DR   EvolutionaryTrace; Q007T0; -.
DR   Proteomes; UP000008227; Unplaced.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IDA:UniProtKB.
DR   GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR   GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); IDA:UniProtKB.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:UniProtKB.
DR   GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; IDA:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IDA:UniProtKB.
DR   GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0048039; F:ubiquinone binding; IDA:UniProtKB.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0022904; P:respiratory electron transport chain; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd00207; fer2; 1.
DR   Gene3D; 1.10.1060.10; -; 1.
DR   Gene3D; 3.10.20.30; -; 1.
DR   InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR   InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR   InterPro; IPR006058; 2Fe2S_fd_BS.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR012675; Beta-grasp_dom_sf.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S.
DR   InterPro; IPR025192; Succ_DH/fum_Rdtase_N.
DR   Pfam; PF13085; Fer2_3; 1.
DR   SUPFAM; SSF46548; SSF46548; 1.
DR   SUPFAM; SSF54292; SSF54292; 1.
DR   TIGRFAMs; TIGR00384; dhsB; 1.
DR   PROSITE; PS00197; 2FE2S_FER_1; 1.
DR   PROSITE; PS51085; 2FE2S_FER_2; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 1.
PE   1: Evidence at protein level;
KW   2Fe-2S; 3D-structure; 3Fe-4S; 4Fe-4S; Acetylation; Complete proteome;
KW   Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding;
KW   Mitochondrion; Mitochondrion inner membrane; Oxidoreductase;
KW   Reference proteome; Transit peptide; Transport;
KW   Tricarboxylic acid cycle.
FT   TRANSIT       1     28       Mitochondrion.
FT   CHAIN        29    280       Succinate dehydrogenase [ubiquinone]
FT                                iron-sulfur subunit, mitochondrial.
FT                                /FTId=PRO_0000343799.
FT   DOMAIN       40    131       2Fe-2S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00465}.
FT   DOMAIN      176    206       4Fe-4S ferredoxin-type.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   REGION      146    218       Interaction with SDHAF1.
FT                                {ECO:0000250|UniProtKB:P21912}.
FT   METAL        93     93       Iron-sulfur 1 (2Fe-2S).
FT   METAL        98     98       Iron-sulfur 1 (2Fe-2S).
FT   METAL       101    101       Iron-sulfur 1 (2Fe-2S).
FT   METAL       113    113       Iron-sulfur 1 (2Fe-2S).
FT   METAL       186    186       Iron-sulfur 2 (4Fe-4S).
FT   METAL       189    189       Iron-sulfur 2 (4Fe-4S).
FT   METAL       192    192       Iron-sulfur 2 (4Fe-4S).
FT   METAL       196    196       Iron-sulfur 3 (3Fe-4S).
FT   METAL       243    243       Iron-sulfur 3 (3Fe-4S).
FT   METAL       249    249       Iron-sulfur 3 (3Fe-4S).
FT   METAL       253    253       Iron-sulfur 2 (4Fe-4S).
FT   BINDING     201    201       Ubiquinone; shared with DHSD.
FT                                {ECO:0000269|PubMed:15989954}.
FT   MOD_RES      51     51       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:Q9CQA3}.
FT   MOD_RES      55     55       N6-acetyllysine.
FT                                {ECO:0000250|UniProtKB:Q9CQA3}.
FT   STRAND       39     46       {ECO:0000244|PDB:1ZOY}.
FT   STRAND       51     53       {ECO:0000244|PDB:3SFD}.
FT   STRAND       57     64       {ECO:0000244|PDB:1ZOY}.
FT   HELIX        65     67       {ECO:0000244|PDB:1ZOY}.
FT   HELIX        72     81       {ECO:0000244|PDB:1ZOY}.
FT   STRAND       94     98       {ECO:0000244|PDB:1ZOY}.
FT   STRAND      103    105       {ECO:0000244|PDB:1ZOY}.
FT   STRAND      108    110       {ECO:0000244|PDB:1ZOY}.
FT   TURN        112    114       {ECO:0000244|PDB:1ZOY}.
FT   STRAND      123    128       {ECO:0000244|PDB:1ZOY}.
FT   STRAND      130    132       {ECO:0000244|PDB:3AEF}.
FT   STRAND      133    137       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       144    152       {ECO:0000244|PDB:1ZOY}.
FT   TURN        163    167       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       174    178       {ECO:0000244|PDB:1ZOY}.
FT   TURN        179    185       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       193    195       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       197    202       {ECO:0000244|PDB:1ZOY}.
FT   TURN        203    205       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       208    219       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       227    232       {ECO:0000244|PDB:1ZOY}.
FT   STRAND      236    238       {ECO:0000244|PDB:1ZOY}.
FT   TURN        239    242       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       250    252       {ECO:0000244|PDB:1ZOY}.
FT   HELIX       259    270       {ECO:0000244|PDB:1ZOY}.
SQ   SEQUENCE   280 AA;  31586 MW;  096B11189EF1ED59 CRC64;
     MAAVVAVSLK RWFPATTLGG ACLQACRGAQ TAAATAPRIK KFAIYRWDPD KTGDKPHMQT
     YEIDLNNCGP MVLDALIKIK NEIDSTLTFR RSCREGICGS CAMNINGGNT LACTRRIDTN
     LDKVSKIYPL PHMYVIKDLV PDLSNFYAQY KSIEPYLKKK DESQEGKQQY LQSIEEREKL
     DGLYECILCA CCSTSCPSYW WNGDKYLGPA VLMQAYRWMI DSRDDFTEER LAKLQDPFSL
     YRCHTIMNCT GTCPKGLNPG KAIAEIKKMM ATYKEKKASA
//
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