ID SDHB_XENTR Reviewed; 284 AA.
AC B0BM36;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 1.
DT 16-JAN-2019, entry version 74.
DE RecName: Full=Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial;
DE EC=1.3.5.1;
DE AltName: Full=Iron-sulfur subunit of complex II;
DE Short=Ip;
DE Flags: Precursor;
GN Name=sdhb;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Iron-sulfur protein (IP) subunit of succinate
CC dehydrogenase (SDH) that is involved in complex II of the
CC mitochondrial electron transport chain and is responsible for
CC transferring electrons from succinate to ubiquinone (coenzyme Q).
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a quinone + succinate = a quinol + fumarate;
CC Xref=Rhea:RHEA:40523, ChEBI:CHEBI:24646, ChEBI:CHEBI:29806,
CC ChEBI:CHEBI:30031, ChEBI:CHEBI:132124; EC=1.3.5.1;
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601;
CC Evidence={ECO:0000250};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000250};
CC -!- COFACTOR:
CC Name=[3Fe-4S] cluster; Xref=ChEBI:CHEBI:21137;
CC Evidence={ECO:0000250};
CC Note=Binds 1 [3Fe-4S] cluster. {ECO:0000250};
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000250};
CC Note=Binds 1 [4Fe-4S] cluster. {ECO:0000250};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC fumarate from succinate (eukaryal route): step 1/1.
CC -!- SUBUNIT: Component of complex II composed of four subunits: the
CC flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a
CC cytochrome b composed of sdhc and sdhd. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}; Matrix side
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the succinate dehydrogenase/fumarate
CC reductase iron-sulfur protein family. {ECO:0000305}.
DR EMBL; BC158270; AAI58271.1; -; mRNA.
DR RefSeq; NP_001120000.1; NM_001126528.1.
DR UniGene; Str.51669; -.
DR ProteinModelPortal; B0BM36; -.
DR SMR; B0BM36; -.
DR STRING; 8364.ENSXETP00000029442; -.
DR PaxDb; B0BM36; -.
DR Ensembl; ENSXETT00000029442; ENSXETP00000029442; ENSXETG00000013435.
DR GeneID; 100144957; -.
DR KEGG; xtr:100144957; -.
DR CTD; 6390; -.
DR Xenbase; XB-GENE-970193; sdhb.
DR eggNOG; KOG3049; Eukaryota.
DR eggNOG; COG0479; LUCA.
DR GeneTree; ENSGT00390000013558; -.
DR HOGENOM; HOG000160590; -.
DR HOVERGEN; HBG005483; -.
DR InParanoid; B0BM36; -.
DR KO; K00235; -.
DR OMA; CTHCYRC; -.
DR OrthoDB; 1264157at2759; -.
DR TreeFam; TF300754; -.
DR Reactome; R-XTR-71403; Citric acid cycle (TCA cycle).
DR UniPathway; UPA00223; UER01006.
DR Proteomes; UP000008143; Unassembled WGS sequence.
DR Bgee; ENSXETG00000013435; Expressed in 18 organ(s), highest expression level in skeletal muscle tissue.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0031966; C:mitochondrial membrane; IBA:GO_Central.
DR GO; GO:0005749; C:mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone); ISS:UniProtKB.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0051538; F:3 iron, 4 sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; ISS:UniProtKB.
DR GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0048039; F:ubiquinone binding; ISS:UniProtKB.
DR GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR GO; GO:0022904; P:respiratory electron transport chain; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 1.10.1060.10; -; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006058; 2Fe2S_fd_BS.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR009051; Helical_ferredxn.
DR InterPro; IPR004489; Succ_DH/fum_Rdtase_Fe-S.
DR InterPro; IPR025192; Succ_DH/fum_Rdtase_N.
DR Pfam; PF13085; Fer2_3; 1.
DR SUPFAM; SSF46548; SSF46548; 1.
DR SUPFAM; SSF54292; SSF54292; 1.
DR TIGRFAMs; TIGR00384; dhsB; 1.
DR PROSITE; PS00197; 2FE2S_FER_1; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 1.
DR PROSITE; PS51379; 4FE4S_FER_2; 1.
PE 2: Evidence at transcript level;
KW 2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron;
KW Iron-sulfur; Membrane; Metal-binding; Mitochondrion;
KW Mitochondrion inner membrane; Oxidoreductase; Reference proteome;
KW Transit peptide; Transport; Tricarboxylic acid cycle.
FT TRANSIT 1 26 Mitochondrion. {ECO:0000250}.
FT CHAIN 27 284 Succinate dehydrogenase [ubiquinone]
FT iron-sulfur subunit, mitochondrial.
FT /FTId=PRO_0000343803.
FT DOMAIN 44 137 2Fe-2S ferredoxin-type.
FT {ECO:0000255|PROSITE-ProRule:PRU00465}.
FT DOMAIN 180 210 4Fe-4S ferredoxin-type.
FT {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT METAL 97 97 Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT METAL 102 102 Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT METAL 105 105 Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT METAL 117 117 Iron-sulfur 1 (2Fe-2S). {ECO:0000250}.
FT METAL 190 190 Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT METAL 193 193 Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT METAL 196 196 Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT METAL 200 200 Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT METAL 247 247 Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT METAL 253 253 Iron-sulfur 3 (3Fe-4S). {ECO:0000250}.
FT METAL 257 257 Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT BINDING 205 205 Ubiquinone; shared with dhsd.
FT {ECO:0000250}.
SQ SEQUENCE 284 AA; 32087 MW; 88CCE71B1DCB3D6C CRC64;
MAAVVFSLRR SGPVFRLPGV LQVCRGAQTA AAAAPASQAE ARIKKFAIYR WDPDKPGDKP
RMQTYEVDLN ECGSMVLDAL IKIKNEMDPT LTFRRSCREG ICGSCAMNIN GGNTLACTVR
IDTNLSKVSK IYPLPHMYVV KDLVPDLSNF YAQYKSIEPY LKKKDESQEG KEQYLQSIED
RDKLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWMIDSRDDY TEERLAKLQD
PFSLYRCHTI MNCTRTCPKG LNPGKAIAEI KKMMATYKER AASV
//
