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Database: UniProt/SWISS-PROT
Entry: SET1B_XENLA
LinkDB: SET1B_XENLA
Original site: SET1B_XENLA 
ID   SET1B_XENLA             Reviewed;        1938 AA.
AC   Q66J90;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   28-MAR-2018, entry version 93.
DE   RecName: Full=Histone-lysine N-methyltransferase SETD1B;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 1B;
GN   Name=setd1b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-4' of histone H3, when part of the SET1 histone
CC       methyltransferase (HMT) complex, but not if the neighboring 'Lys-
CC       9' residue is already methylated. H3 'Lys-4' methylation
CC       represents a specific tag for epigenetic transcriptional
CC       activation (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; BC081016; AAH81016.1; -; mRNA.
DR   RefSeq; NP_001087630.1; NM_001094161.1.
DR   UniGene; Xl.41806; -.
DR   ProteinModelPortal; Q66J90; -.
DR   SMR; Q66J90; -.
DR   PRIDE; Q66J90; -.
DR   GeneID; 447454; -.
DR   KEGG; xla:447454; -.
DR   CTD; 447454; -.
DR   Xenbase; XB-GENE-5842376; setd1b.
DR   HOVERGEN; HBG055596; -.
DR   KO; K11422; -.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0048188; C:Set1C/COMPASS complex; IEA:InterPro.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0051568; P:histone H3-K4 methylation; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   CDD; cd12549; RRM_Set1B; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR024657; COMPASS_Set1_N-SET.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR034468; Set1B_RRM.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR037842; SETD1B.
DR   PANTHER; PTHR22884:SF475; PTHR22884:SF475; 1.
DR   Pfam; PF11764; N-SET; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01291; N-SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00360; RRM; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Chromosome; Methyltransferase;
KW   Nucleus; RNA-binding; S-adenosyl-L-methionine; Transcription;
KW   Transcription regulation; Transferase.
FT   CHAIN         1   1938       Histone-lysine N-methyltransferase
FT                                SETD1B.
FT                                /FTId=PRO_0000316997.
FT   DOMAIN      111    199       RRM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00176}.
FT   DOMAIN     1799   1916       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN     1922   1938       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   COMPBIAS    498    544       Ser-rich.
FT   COMPBIAS    647    712       Pro-rich.
FT   COMPBIAS    977   1134       Glu-rich.
SQ   SEQUENCE   1938 AA;  216257 MW;  B8DD492A64888086 CRC64;
     MSFKEAKPGE RGKNPEDHGR KQAASWMNGM EAANQPSTSA EKKSHHWRSY KLIIDPALRK
     GQQKLYRYDG LSFSMPNSGA PPVDSVRDPR IGRIWTKTKE LDLPVPKLKI DEFYVGPVPP
     KQVTFAKLND NIRENFLGDM CKKYGEVEEV EILYNPKNKK HLGIAKVIFA TVKGAKDAVK
     HLHNTSVMGN IIHAELDTKG ETRMRFYELL VNGYYTPQTL PVGSDLDASP TVNETPQVVE
     PVKRTKETAV GASVTPNSST PFSHDTAYSS SRQGTPNSYS QFTPQSQGTP HTPRLGTPFS
     QDSSYSSRQT TPAFHYGQDS SFKPRRHENK FTDAYNRRPG HHYVHSSGSY RGPENTFNVT
     RPQAETVQFP RTPPLSHSSG NNKSAFSPYQ GSTVFPQTDD NQYPQTSRDM EYRRTGPPTS
     DSYSDGSLEL KLVKEKPEEP PPPEPDSTTE QKASFAQTPE RCATPGTPTL EAEMQHDSLD
     TRIAMLLKEQ RTQLHLISSD QNSDSEIRME GSPISSSSSQ LSPIPPYSSS SHYQDVTPSS
     RPSSTGLEDI SPTPLPDSDD DEPIPGTASL CQNSRSASPI DQINQPVRKM ETLDNKELVV
     GDETPTSEKM DEGHPSSGED MEISDDEVTP SPITSAECAI TSSSVIPILP PGFPPLPPPP
     PPQSGFPMPP PLPPPPPPTH PSVTVPPPPL PAPPGVPPHH ILHHPPPYHH FPVMQGEMMN
     VLGNHWGGMT MSFQMQTQML SRMMQGQGSY PYHHFMGGSM QFGNQLPYRP FALSAHLSRG
     QPWPPLPKFD PSVPPPGYEP KKEDPHKATV DGVLQVIVKE LKAIMKRDLN RKMVEVVAFR
     AFDEWWDKKE RLAKQSLTPV KSGESKDEDK QKTKEHITSS LLESWNKGEG LGFEGIGLGI
     GLRGAIRLPS FKVKRKEPPD AALAGDQKRI RPSHSVDDED EESERDRDIS GTASDLSKKD
     ADAVNIRRRP ARPLDSEGEE EVESEGDDGE TSDKEAFEKE DQDAGSVSAL SSKKRLYGEK
     EDEEDETQSS GKEEDLVSEE EDITSVASSR AEMDSSDESD ESSEYESSSD SDDEIEEEDD
     DDEEEELVFE DDQSEELDLG QEDYIETDRE EDFFKEDVSE CSSPVKAEAD MELEDDDVQK
     LEQDVAHQTA QDTSHLRKKD LDVPLVESKE HKQDTFDKME RLSAVPMQQN VFKEHEKAPS
     PMNEEEEYIE LRLEPVPLVP DNAPPAVQEP MIIRPLTPTG AFGESGPVLK LEEPKLQVNL
     AHFVAEDEDL YPRTPGRDTA AHSDTEVTFQ PGLKVAPSSL PLLQSHNKEE ECLLPPEKHT
     GHLKVTKTLS EEELPRTPGR DILVKSSHLG KSQSTETIPA TPGSDAPLTG NSLTLTSPHI
     PGSPFSYLSQ SPGIINSGIP RTPGRDFNFT PIFPESNSIF PSHPSGKKSS VDEPDEKSFK
     EPTSASLTMN SVPSPIPFAS PPRGVPHMDI RLETDDLESS DTQAYLSDKL LSEESECEFT
     KGQLPSTDES APSPPFPPTD KRKGPKKPLA AHEFEACVAL SEGALGKQLF IGQPDSVSGI
     KDPAAVPLDF RNDGLSENTV HDPIIQKVPL KELENQWNEV LKEEEEDISK HKKSRNSRLN
     KLYDEFSTLP SPEYSPPRAM FKPRSEFEEM TILYDIWNGG IDDEDMKYMC ITYDRLLQQD
     NGMDWLNDTL WVYHPPTSVY SPKKKKRDDG LREHVTGCAR SEGYYKIDKK DKLKYLINNR
     SLADEPPIDT QGKSIPAQPQ ASTRAGSERR SEQRRLLSSF TGSCDSDLLK FNQLKFRKKK
     IRFCKSHIHD WGLFAMEPIV ADEMVIEYVG QNIRQVIADM REKRYEDEGI GSSYMFRVDH
     DTIIDATKCG NFARFINHSC NPNCYAKVVT VESQKKIVIY SKQYINVNEE ITYDYKFPIE
     DVKIPCLCGA ENCRGTLN
//
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